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SPLICING FACTOR

  • Splicing factor
  • Proteins that aid in intron removal from messenger RNA

    spliceosomes. Splicing factors regulate the binding of the snRNPs U1 and U2 to the 3' and 5' ends of the intron during splicing and can either be splicing promoters

    Splicing factor

    Splicing_factor

  • Alternative splicing
  • Process by which a gene can code for multiple proteins

    Alternative splicing, alternative RNA splicing, or differential splicing is an alternative splicing process during gene expression that allows a single

    Alternative splicing

    Alternative splicing

    Alternative_splicing

  • RNA splicing
  • Process in molecular biology

    of RNA splicing occur in nature; the type of splicing depends on the structure of the spliced intron and the catalysts required for splicing to occur

    RNA splicing

    RNA splicing

    RNA_splicing

  • Cell nucleus
  • Organelle in eukaryotic cells

    phosphorylation of specific proteins. The splicing speckles are also known as nuclear speckles (nuclear specks), splicing factor compartments (SF compartments),

    Cell nucleus

    Cell nucleus

    Cell_nucleus

  • Serine/arginine-rich splicing factor 1
  • Protein-coding gene in the species Homo sapiens

    splicing factor involved in pre-mRNA splicing. SRSF1 is the gene that codes for ASF/SF2 and is found on chromosome 17. The resulting splicing factor is

    Serine/arginine-rich splicing factor 1

    Serine/arginine-rich splicing factor 1

    Serine/arginine-rich_splicing_factor_1

  • SRSF2
  • Protein-coding gene in humans

    Serine/arginine-rich splicing factor 2 is a protein that in humans is encoded by the SRSF2 gene. MDS-associated splicing factor SRSF2 affects the expression

    SRSF2

    SRSF2

    SRSF2

  • Prolactinoma
  • Pituitary gland tumor which secretes the hormone prolactin

    prolactinoma, in patients with no family history of pituitary tumors, the splicing factor 3B1 gene (SF3B1) has been found as a common causative mutation. This

    Prolactinoma

    Prolactinoma

    Prolactinoma

  • Splicing factor YJU2
  • Protein found in humans

    Splicing factor YJU2 is a protein that in humans is encoded by the YJU2 gene (previously CCDC94). The YJU2 protein is part of the spliceosome, and is

    Splicing factor YJU2

    Splicing factor YJU2

    Splicing_factor_YJU2

  • U2 small nuclear RNA auxiliary factor 1
  • Protein-coding gene in the species Homo sapiens

    Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene. This gene belongs to the splicing factor SR family of genes

    U2 small nuclear RNA auxiliary factor 1

    U2 small nuclear RNA auxiliary factor 1

    U2_small_nuclear_RNA_auxiliary_factor_1

  • SR protein
  • block splicing of the exon. Spliceosome Exon Intron Exon Junction Complex Long JC, Caceres JF (January 2009). "The SR protein family of splicing factors: master

    SR protein

    SR protein

    SR_protein

  • SFRS7
  • Protein-coding gene in the species Homo sapiens

    Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in

    SFRS7

    SFRS7

    SFRS7

  • SFPQ
  • Non-coding RNA in the species Homo sapiens

    Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the SFPQ gene. SFPQ has been shown to interact with PTBP1, NONO

    SFPQ

    SFPQ

    SFPQ

  • SF3B1
  • Protein-coding gene in humans

    Splicing factor 3B subunit 1 is a protein that in humans is encoded by the SF3B1 gene. This gene encodes subunit 1 of the splicing factor 3b protein complex

    SF3B1

    SF3B1

    SF3B1

  • Myelodysplastic syndrome
  • Diverse collection of blood-related cancers

    seen in patients without 5q deletion.[citation needed] Mutations in splicing factors have been found in 40–80% of people with MDS, with a higher incidence

    Myelodysplastic syndrome

    Myelodysplastic syndrome

    Myelodysplastic_syndrome

  • SF3A3
  • Protein-coding gene in the species Homo sapiens

    Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene. This gene encodes subunit 3 of the splicing factor 3a protein complex

    SF3A3

    SF3A3

    SF3A3

  • SLU7
  • Protein-coding gene in the species Homo sapiens

    Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene. Pre-mRNA splicing occurs in two sequential transesterification

    SLU7

    SLU7

    SLU7

  • SFRS9
  • Protein-coding gene in the species Homo sapiens

    Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative

    SFRS9

    SFRS9

    SFRS9

  • Survival motor neuron domain containing 1
  • Protein-coding gene in the species Homo sapiens

    neuron-related-splicing factor 30 (SMNDC1) is a protein that in humans is encoded by the SMNDC1 gene. SMNDC1 is an important splicing regulator and is

    Survival motor neuron domain containing 1

    Survival motor neuron domain containing 1

    Survival_motor_neuron_domain_containing_1

  • SF1 (gene)
  • Protein-coding gene in the species Homo sapiens

    Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene. SF1 is a splicing factor which

    SF1 (gene)

    SF1 (gene)

    SF1_(gene)

  • SFRS6
  • Protein-coding gene in the species Homo sapiens

    involved in mRNA splicing and may play a role in site selection in alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family

    SFRS6

    SFRS6

    SFRS6

  • U2AF2
  • Protein-coding gene in humans

    Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene. In eukaryotes, the introns in the transcribed pre-mRNA first

    U2AF2

    U2AF2

    U2AF2

  • SFSWAP
  • Protein-coding gene in the species Homo sapiens

    a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition

    SFSWAP

    SFSWAP

    SFSWAP

  • SF3B4
  • Protein-coding gene in the species Homo sapiens

    Splicing factor 3B subunit 4 is a protein that in humans is encoded by the SF3B4 gene. This gene encodes one of four subunits of the splicing factor 3b

    SF3B4

    SF3B4

    SF3B4

  • SFRS4
  • Protein-coding gene in the species Homo sapiens

    Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene. SFRS4 has been shown to interact with Pinin. GRCh38:

    SFRS4

    SFRS4

    SFRS4

  • SFRS5
  • Protein-coding gene in the species Homo sapiens

    Splicing factor, arginine/serine-rich 5 is a protein that in humans is encoded by the SFRS5 gene. GRCh38: Ensembl release 89: ENSG00000100650 – Ensembl

    SFRS5

    SFRS5

    SFRS5

  • SF3B6
  • Protein-coding gene in the species Homo sapiens

    Splicing factor 3B subunit 6, is a protein encoded by SF3B6 gene in vertebrates. This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex

    SF3B6

    SF3B6

    SF3B6

  • SFRS3
  • Protein-coding gene in the species Homo sapiens

    Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene. UCSC Genome Browser View UCSC Gene details page SFRS3

    SFRS3

    SFRS3

    SFRS3

  • ZRSR2
  • Protein-coding gene in the species Homo sapiens

    with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role

    ZRSR2

    ZRSR2

    ZRSR2

  • Non-POU domain-containing octamer-binding protein
  • Protein-coding gene in the species Homo sapiens

    Drosophila behaviour/human splicing (DBHS) family of proteins. Proteins in the DHBS family include mammalian SFPQ (splicing factor, proline- and glutamine-rich;

    Non-POU domain-containing octamer-binding protein

    Non-POU domain-containing octamer-binding protein

    Non-POU_domain-containing_octamer-binding_protein

  • SF3B3
  • Protein-coding gene in the species Homo sapiens

    Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene. This gene encodes subunit 3 of the splicing factor 3b protein complex

    SF3B3

    SF3B3

    SF3B3

  • RBM17
  • Protein-coding gene in the species Homo sapiens

    Splicing factor 45 is a protein that in humans is encoded by the RBM17 gene. GRCh38: Ensembl release 89: ENSG00000134453 – Ensembl, May 2017 GRCm38: Ensembl

    RBM17

    RBM17

    RBM17

  • SFRS11
  • Protein-coding gene in the species Homo sapiens

    Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene. This gene encodes 54-kD nuclear protein that contains

    SFRS11

    SFRS11

    SFRS11

  • Transcriptome instability
  • instability is a genome-wide, pre-mRNA splicing-related characteristic of certain cancers. In general, pre-mRNA splicing is dysregulated in a high proportion

    Transcriptome instability

    Transcriptome_instability

  • SF3A1
  • Protein-coding gene in the species Homo sapiens

    Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene. This gene encodes subunit 1 of the splicing factor 3a protein complex

    SF3A1

    SF3A1

    SF3A1

  • The X Factor (British TV series)
  • British television series (2004–2018)

    The X Factor is a British reality television music competition – that spawned the global X Factor franchise – created by Simon Cowell. Premiering on 4

    The X Factor (British TV series)

    The_X_Factor_(British_TV_series)

  • Sex-lethal
  • Protein family

    3' splice site. This binding prevents the general splicing factor U2AF from binding, thus promoting the use of a female-specific upstream 3' splice site

    Sex-lethal

    Sex-lethal

    Sex-lethal

  • PUF60
  • Protein-coding gene in the species Homo sapiens

    Poly(U)-binding-splicing factor PUF60 is a protein that in humans is encoded by the PUF60 gene. The protein encoded by this gene is a Ro RNP-binding protein

    PUF60

    PUF60

    PUF60

  • RP9
  • Protein-coding gene in humans

    localizes in nuclear speckles containing the splicing factor SRSF2 and interacts directly with another splicing factor, U2AF35. Mutations in PAP1 underlie autosomal

    RP9

    RP9

    RP9

  • SRSF10
  • Protein found found in humans

    Serine/arginine-rich splicing factor 10 is a protein that in humans is encoded by the SRSF10 gene (previously SFRS13A, FUSIP1, or FUSIP2). This gene product

    SRSF10

    SRSF10

    SRSF10

  • SF3A2
  • Protein-coding gene in the species Homo sapiens

    Splicing factor 3A subunit 2 is a protein that in humans is encoded by the SF3A2 gene. This gene encodes subunit 2 of the splicing factor 3a protein complex

    SF3A2

    SF3A2

    SF3A2

  • Exonic splicing enhancer
  • DNA sequence motif

    an exonic splicing enhancer (ESE) is a DNA sequence motif consisting of 6 bases within an exon that directs, or enhances, accurate splicing of heterogeneous

    Exonic splicing enhancer

    Exonic_splicing_enhancer

  • DHX38
  • Protein-coding gene in the species Homo sapiens

    Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 is an enzyme that in humans is encoded by the DHX38 gene. DEAD box proteins, characterized by

    DHX38

    DHX38

    DHX38

  • PRPF8
  • Protein-coding gene in the species Homo sapiens

    Pre-mRNA-processing-splicing factor 8 is a protein that in humans is encoded by the PRPF8 gene. Pre-mRNA splicing occurs in 2 sequential transesterification

    PRPF8

    PRPF8

    PRPF8

  • ASF
  • Topics referred to by the same term

    microbial species Serine/arginine-rich splicing factor 1, a protein also known as alternative splicing factor 1 (ASF) Advanced Synchronization Facility

    ASF

    ASF

  • Poison exon
  • Biological phenomenon

    Dysregulation of components of the splicing machinery can also cause dysregulation of PE inclusion. Mutations in the splicing factor SF3B1 have been found to promote

    Poison exon

    Poison_exon

  • TRA2B
  • Protein-coding gene in the species Homo sapiens

    Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (SFRS10)

    TRA2B

    TRA2B

    TRA2B

  • SF3B5
  • Protein-coding gene in the species Homo sapiens

    Splicing factor 3B subunit 5 is a protein that in humans is encoded by the SF3B5 gene. The protein is a part of splicing factor 3b. GRCh38: Ensembl release

    SF3B5

    SF3B5

    SF3B5

  • YJU2B
  • Protein found in humans

    Probable splicing factor YJU2B is a protein that in humans is encoded by the JU2B gene (previously CCDC130). It has been predicted that it is part of

    YJU2B

    YJU2B

    YJU2B

  • James L. Manley
  • British biologist

    mRNA splicing. Manley and his coworkers codiscovered the first alternative splicing factor (SR protein), characterized how this and other splicing regulatory

    James L. Manley

    James L. Manley

    James_L._Manley

  • SF3B2
  • Protein-coding gene in the species Homo sapiens

    Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene. This gene encodes subunit 2 of the splicing factor 3b protein complex

    SF3B2

    SF3B2

    SF3B2

  • Stress granule
  • Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress

    Wauquier C, Soin R, Dierick JF, Gueydan C, Kruys V (June 2010). "The splicing factor ASF/SF2 is associated with TIA-1-related/TIA-1-containing ribonucleoproteic

    Stress granule

    Stress granule

    Stress_granule

  • Titin
  • Largest known protein in human muscles

    alternative splicing creates some transcripts that do not encounter the premature stop codon, ameliorating its effect. mRNA splicing factors such as RBM20

    Titin

    Titin

    Titin

  • Hydroxylysine
  • Chemical compound

    recently been shown to be a lysyl hydroxylase which modifies an RNA splicing factor producing the (5S) stereoisomer. Additionally, in E. coli, there has

    Hydroxylysine

    Hydroxylysine

    Hydroxylysine

  • Primary transcript
  • RNA produced by transcription

    include the 5' cap, 3'-polyadenylation, and alternative splicing. In particular, alternative splicing directly contributes to the diversity of mRNA found

    Primary transcript

    Primary transcript

    Primary_transcript

  • PRPF31
  • Protein-coding gene in the species Homo sapiens

    humans is encoded by the PRPF31 gene. PRPF31 is the gene coding for the splicing factor hPRP31. It is essential for the formation of the spliceosome hPRP31

    PRPF31

    PRPF31

    PRPF31

  • Minigene
  • abundance of alternative splicing, which occurs in most human genes, and the specificity in which splicing is carried out in vivo. Splicing is distinctly conducted

    Minigene

    Minigene

    Minigene

  • SREK1
  • Protein-coding gene in the species Homo sapiens

    been predicted to regulate alternative splicing through its interaction with other splice factors (modulating splice site selection). In particular, it is

    SREK1

    SREK1

    SREK1

  • H3B-8800
  • Pharmaceutical compound

    acts as an inhibitor of the SF3B1 protein, which forms part of the splicing factor 3b protein complex. This is commonly mutated in some forms of cancer

    H3B-8800

    H3B-8800

    H3B-8800

  • Mir-505 microRNA precursor family
  • RNA family

    interaction between leukemia/lymphoma-related factor (LRF) and alternative splicing factor/splicing factor 2 (ASF/SF2) affects mouse embryonic fibroblast

    Mir-505 microRNA precursor family

    Mir-505_microRNA_precursor_family

  • AAR2
  • Gene that encodes a protein essential for pre-mRNA splicing

    AAR2 splicing factor is a protein that in humans is encoded by the gene AAR2. This protein is essential for pre-mRNA splicing, a step in post-transcriptional

    AAR2

    AAR2

    AAR2

  • SRPK1
  • Protein-coding gene in the species Homo sapiens

    constitutive and alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this

    SRPK1

    SRPK1

    SRPK1

  • Retinitis pigmentosa
  • Gradual retinal degeneration leading to progressive sight loss

    MW, Bhattacharya SS (2009). "Study of Gene-Targeted Mouse Models of Splicing Factor Gene Prpf31 Implicated in Human Autosomal Dominant Retinitis Pigmentosa

    Retinitis pigmentosa

    Retinitis pigmentosa

    Retinitis_pigmentosa

  • DDX39B
  • Protein-coding gene in humans

    that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear

    DDX39B

    DDX39B

    DDX39B

  • HITS-CLIP
  • Method used in molecular biology

    neuron-specific RNA-binding protein and splicing factor NOVA1 and NOVA2; since then a number of other splicing factor maps have been generated, including

    HITS-CLIP

    HITS-CLIP

  • C1QBP
  • Protein-coding gene in the species Homo sapiens

    This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. C1QBP is 282 amino

    C1QBP

    C1QBP

    C1QBP

  • PTBP1
  • Protein-coding gene in the species Homo sapiens

    (March 1993). "Cloning and characterization of PSF, a novel pre-mRNA splicing factor". Genes & Development. 7 (3): 393–406. doi:10.1101/gad.7.3.393. PMID 8449401

    PTBP1

    PTBP1

    PTBP1

  • Clonal hematopoiesis
  • Expansion of blood cells

    ASXL1), RNA splicing factors (SF3B1, SRSF2), TP53, and PPM1D. It is likely that a mutational progression occurs, such that splicing factors are mutated

    Clonal hematopoiesis

    Clonal_hematopoiesis

  • SON (gene)
  • Protein-coding gene in the species Homo sapiens

    large Ser/Arg (SR)-related protein, which is a splicing co-factor that contributes to an efficient splicing within cell cycle progression. It is also known

    SON (gene)

    SON (gene)

    SON_(gene)

  • RBFOX1
  • Protein-coding gene in the species Homo sapiens

    peptide. The third conserved domain of RBFOX1 is the ELAV/HuD family splicing factor. HUD is human paraneoplastic encephalomyelitis antigen D whereas ELAV

    RBFOX1

    RBFOX1

    RBFOX1

  • Susan Berget
  • American biochemist

    differential splicing choices, such as between the pre-mRNA for calcitonin versus CGRP, by showing that there is some sort of "splicing factor" that binds

    Susan Berget

    Susan_Berget

  • ESS2
  • Protein-coding gene in the species Homo sapiens

    Splicing factor ESS-2 homolog is a protein that in humans is encoded by the ESS2 gene (previously DGCR13 or DGCR14). This protein may be involved in RNA

    ESS2

    ESS2

    ESS2

  • PPM1G
  • Protein-coding gene in the species Homo sapiens

    phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies

    PPM1G

    PPM1G

    PPM1G

  • RNA recognition motif
  • Protein domain

    translation (PABP, La, Hu). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor appears to have two RRM-like domains with specialised

    RNA recognition motif

    RNA recognition motif

    RNA_recognition_motif

  • TAR DNA-binding protein 43
  • Protein found in humans

    addition, this protein regulates alternate splicing of the CFTR gene. In particular, TDP-43 is a splicing factor binding to the intron8/exon9 junction of

    TAR DNA-binding protein 43

    TAR DNA-binding protein 43

    TAR_DNA-binding_protein_43

  • Chromosome 19
  • Human chromosome

    SFRS14: encoding protein Putative splicing factor, arginine/serine-rich 14 SFRS16: encoding protein Splicing factor, arginine/serine-rich 16 SLC5A5: Solute

    Chromosome 19

    Chromosome 19

    Chromosome_19

  • PRPF6
  • Protein-coding gene in the species Homo sapiens

    Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene. The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly

    PRPF6

    PRPF6

    PRPF6

  • NSRP1
  • Protein-coding gene in humans

    are rich in RNA splicing factors. NSRP1 interacts with other splicing factors including SRSF1 and SRSF2 and modulates pre-mRNA splicing. Knockout of the

    NSRP1

    NSRP1

    NSRP1

  • PNISR
  • Protein-coding gene in the species Homo sapiens

    Splicing factor, arginine/serine-rich 18 is a protein that in humans is encoded by the SFRS18 gene. SFRS18 has been shown to interact with Pinin. GRCh38:

    PNISR

    PNISR

    PNISR

  • XAB2
  • Protein-coding gene in the species Homo sapiens

    Pre-mRNA-splicing factor SYF1 is a protein that in humans is encoded by the XAB2 gene. XAB2 has been shown to interact with ERCC8 and XPA. GRCh38: Ensembl

    XAB2

    XAB2

    XAB2

  • Master regulator gene
  • Gene at the top of a regulation hierarchy

    the Twist transcription factor. Other genes reported as master regulators code for SR proteins, which function as splicing factors, and some noncoding RNAs

    Master regulator gene

    Master_regulator_gene

  • WBP11
  • Protein-coding gene in the species Homo sapiens

    WW domain binding protein 11 (WBP11) Npw38-binding protein (NpwBP) Splicing factor that Interacts with PQBP-1 and PP1 (SIPP1) SH3 domain binding Protein

    WBP11

    WBP11

    WBP11

  • RNA binding protein, fox-1 homolog (C. elegans) 3
  • Gene of the species Homo sapiens

    gene. It is related to the alternative splicing factors Rbfox1 and Rbfox2, but instead of its involvement in splicing, it is most well known as the nuclear

    RNA binding protein, fox-1 homolog (C. elegans) 3

    RNA binding protein, fox-1 homolog (C. elegans) 3

    RNA_binding_protein,_fox-1_homolog_(C._elegans)_3

  • Spliceosome
  • Molecular machine that removes intron RNA from the primary transcript

    sites of mRNA splicing or storage sites of mRNA splicing factors. It is now understood that nuclear speckles help concentrate splicing factors near genes

    Spliceosome

    Spliceosome

    Spliceosome

  • Prp8
  • DNA during splicing. Prp8 is also more involved with maintaining proper conformation of the bound RNA cofactors and substrates of the splicing reaction

    Prp8

    Prp8

    Prp8

  • Zebrafish
  • Species of fish

    initiate RNA splicing. These genes have the DNA base pairs AC and TG as repeated sequences at the ends of each intron. On the 3'ss (3' splicing site), the

    Zebrafish

    Zebrafish

    Zebrafish

  • Protein splicing
  • Post-translational removal of peptide sequences from a protein sequence

    (ATP) or guanosine triphosphate (GTP). Normally, splicing is associated only with pre-mRNA splicing. This precursor protein contains three segments—an

    Protein splicing

    Protein splicing

    Protein_splicing

  • Factor VIII
  • Blood-clotting protein

    Coagulation factor VIII (factor VIII, FVIII, also known as antihemophilic factor A (AHF)) is an essential blood clotting protein. In humans, it is encoded

    Factor VIII

    Factor VIII

    Factor_VIII

  • Insulin-like growth factor 1
  • Protein found in humans

    fetal growth factor, as it is essential for a normal embryonic development and is highly expressed in embryonic and neonatal tissues. A splice variant of

    Insulin-like growth factor 1

    Insulin-like growth factor 1

    Insulin-like_growth_factor_1

  • DHX32
  • Protein-coding gene in the species Homo sapiens

    Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 is an enzyme that in humans is encoded by the DHX32 gene. DEAD box proteins, characterized

    DHX32

    DHX32

    DHX32

  • Isoform
  • Different products from the same gene

    Alternative splicing generally describes a tightly regulated process in which alternative transcripts are intentionally generated by the splicing machinery

    Isoform

    Isoform

    Isoform

  • LUC7L3
  • Protein-coding gene in the species Homo sapiens

    LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene. This gene

    LUC7L3

    LUC7L3

    LUC7L3

  • MIAT (gene)
  • alternative splicing has a role in SZ pathology. MIAT is associated with alternative splicing through its interaction with splicing factor 1(SF1) and with

    MIAT (gene)

    MIAT (gene)

    MIAT_(gene)

  • The Cancer Genome Atlas
  • Project to catalogue genetic mutations responsible for cancer

    Silvia; Yu, Lihua (2018-04-03). "Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types". Cell

    The Cancer Genome Atlas

    The_Cancer_Genome_Atlas

  • The X Factor (American TV series)
  • American reality television music competition show

    The X Factor, also known as The X Factor USA, is an American reality television music competition show created by Simon Cowell and produced by FremantleMedia

    The X Factor (American TV series)

    The_X_Factor_(American_TV_series)

  • NKAPD1
  • Human NKAPD1 Protein

    Experimental/Biochemical Data 0.502 Possible splicing regulator related to cell survival Ubiquitous nucleus SYF2 SYF2 pre-mRNA splicing factor Co-Expression, Experimental/Biochemical

    NKAPD1

    NKAPD1

    NKAPD1

  • X chromosome
  • Sex chromosome present in both sexes in the XY and X0 sex-determination systems

    encoding protein Retrotransposon Gag like 3 SFRS17A: encoding protein Splicing factor, arginine/serine-rich 17A SLC38A5: encoding protein Solute carrier

    X chromosome

    X chromosome

    X_chromosome

  • Exon junction complex
  • Protein complex assembled on mRNA

    joined together during RNA splicing. The EJC has major influences on translation, surveillance, localization of the spliced mRNA, and m6A methylation.

    Exon junction complex

    Exon junction complex

    Exon_junction_complex

  • DHX15
  • Protein-coding gene in the species Homo sapiens

    Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 is an enzyme that in humans is encoded by the DHX15 gene. The protein encoded by this

    DHX15

    DHX15

    DHX15

  • Splicing regulatory element
  • constitutive or alternative splicing of this pre-mRNA. SREs recruit trans-acting splicing factors to activate or suppress the splice site recognition or spliceosome

    Splicing regulatory element

    Splicing_regulatory_element

  • Housekeeping gene
  • Gene which maintains basic cellular functions

    regulating the pre-mRNA splicing process CCNL2 NM_030937 Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates

    Housekeeping gene

    Housekeeping_gene

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SPLICING FACTOR

  • Jagannath
  • Boy/Male

    Hindu

    Jagannath

    Lord of the world, Pricing the Lord

    Jagannath

  • Pender
  • Surname or Lastname

    English

    Pender

    English : occupational name for an official who was responsible for rounding up stray animals and placing them in a pound, from an agent derivative of Middle English pind(en) ‘to shut up or enclose’. Black and MacLysaght quote Woulfe’s opinion that in Ireland this is often a reduced form of Prendergast.

    Pender

  • Bhettr
  • Boy/Male

    Indian, Sanskrit

    Bhettr

    Breaking; Splitting

    Bhettr

  • Bissell
  • Surname or Lastname

    English

    Bissell

    English : from Middle English buyscel, busshell, bysshell ‘bushel’, ‘measure of grain’ (Old French boissel, buissel, of Gaulish origin), hence a metonymic occupational name for a grain merchant or factor, one who measured grain. The name may also have been applied to a maker of vessels designed to hold or measure out a bushel.English : from a diminutive of Biss.Respelling of German Biesel, a habitational name from Bisel in Alsace.

    Bissell

  • Dari
  • Boy/Male

    Indian, Sanskrit

    Dari

    Splitting; Opening; Moving Slowly

    Dari

  • Pound
  • Surname or Lastname

    English

    Pound

    English : from Middle English p(o)und ‘enclosure (especially for confining animals)’; a topographic name for someone who lived near an enclosure in which animals were kept, or a metonymic occupational name for an official responsible for rounding up stray animals and placing them in a pound.Probably a translation of German Pfund or the North German cognate Pund.

    Pound

  • Jagannathan | ஜகந்நாதந 
  • Boy/Male

    Tamil

    Jagannathan | ஜகந்நாதந 

    Lord of the world, Pricing the Lord

    Jagannathan | ஜகந்நாதந 

  • Cozbi
  • Biblical

    Cozbi

    a liar; sliding away

    Cozbi

  • Peck
  • Surname or Lastname

    English (mainly East Anglia)

    Peck

    English (mainly East Anglia) : metonymic occupational name for someone who dealt in weights and measures, for example a grain factor, from Middle English pekke ‘peck’ (an old measure of dry goods equivalent to eight quarts or a quarter of a bushel).English : variant of Peak 1.Irish : variant of Peak 2.South German : variant of Beck.North German and Dutch : metonymic occupational name for someone who prepared or sold pitch, from Middle Low German pek, Middle Dutch pec, pic.Dutch : from Middle Dutch pec, pick ‘desperate straits’, hence a nickname for a person in difficult circumstances or perhaps for someone with a gloomy disposition.

    Peck

  • Jagannathan
  • Boy/Male

    Hindu

    Jagannathan

    Lord of the world, Pricing the Lord

    Jagannathan

  • Cozbi
  • Girl/Female

    Biblical

    Cozbi

    A liar, sliding away.

    Cozbi

  • Gooch
  • Surname or Lastname

    English (mainly East Anglia)

    Gooch

    English (mainly East Anglia) : variant of Goff.Possibly an Americanized spelling of German Gutsch.Several bearers of the name Gooch came from England to VA in the 17th century, with family tradition placing them in a town called Goochland. The best known of these early immigrants was VA colonial governor Sir William Gooch (1681–1751).

    Gooch

  • Dandekar
  • Boy/Male

    Hindu, Indian

    Dandekar

    Placing Side by Side

    Dandekar

  • Jagannath | ஜகந்நாத
  • Boy/Male

    Tamil

    Jagannath | ஜகந்நாத

    Lord of the world, Pricing the Lord

    Jagannath | ஜகந்நாத

  • Todika
  • Girl/Female

    Indian, Sanskrit

    Todika

    Splitting; Breaking

    Todika

  • Daniel
  • Surname or Lastname

    English, French, Spanish, Portuguese, German, Polish, Czech, Slovak, Hungarian (Dániel), Romanian, and Jewish

    Daniel

    English, French, Spanish, Portuguese, German, Polish, Czech, Slovak, Hungarian (Dániel), Romanian, and Jewish : from the Hebrew personal name Daniel ‘God is my judge’, borne by a major prophet in the Bible. The major factor influencing the popularity of the personal name (and hence the frequency of the surname) was undoubtedly the dramatic story in the Book of Daniel, recounting the prophet’s steadfast adherence to his religious faith in spite of pressure and persecution from the Mesopotamian kings in whose court he served: Nebuchadnezzar and Belshazzar (at whose feast Daniel interpreted the mysterious message of doom that appeared on the wall, being thrown to the lions for his pains). The name was also borne by a 2nd-century Christian martyr and by a 9th-century hermit, the legend of whose life was popular among Christians during the Middle Ages; these had a minor additional influence on the adoption of the Christian name. Among Orthodox Christians in Eastern Europe the name was also popular as being that of a 4th-century Persian martyr, who was venerated in the Orthodox Church.Irish : reduced form of McDaniel, which is actually a variant of McDonnell, from the Gaelic form of Irish Donal (equivalent to Scottish Donald), erroneously associated with the Biblical personal name Daniel. See also O’Donnell.Peter Daniel was one of the pioneer settlers in the 17th century in Stafford County, VA, where he was a justice of the peace. His grandson, Peter Vivian Daniel, was a U.S. Supreme Court justice from 1841 to his death in Richmond, VA, in 1860.

    Daniel

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