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Protein family
Transporter associated with antigen processing (TAP) protein complex belongs to the ATP-binding-cassette transporter family. It delivers cytosolic peptides
Transporter associated with antigen processing
Transporter_associated_with_antigen_processing
Immunological process
Antigen processing, or the cytosolic pathway, is an immunological process that prepares antigens for presentation to special cells of the immune system
Antigen_processing
Vital immune process that is essential for T cell immune response triggering
(ER) via the action of heat shock proteins and the transporter associated with antigen processing (TAP) which translocates the cytosolic peptides into
Antigen_presentation
Protein-coding gene in the species Homo sapiens
Transporter associated with antigen processing 1 (TAP1) is a protein that in humans is encoded by the TAP1 gene. A member of the ATP-binding cassette transporter
TAP1
Type of protein
class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic
Tapasin
Gene family
"Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing". The EMBO Journal. 20 (17): 4964–72. doi:10.1093/emboj/20
ABC_transporter
Topics referred to by the same term
studying protein interactions Timor–Alor–Pantar languages Transporter associated with antigen processing (TAP), a protein complex 2,4,6-triaminopyrimidine (TAP)
Tap
Protein of the immune system
the ER is accomplished by the transporter associated with antigen processing (TAP). TAP is a member of the ABC transporter family and is a heterodimeric
MHC_class_I
Medical condition
class I deficiency" is associated with TAP2, TAP1, or TAPBP deficiencies. TAP (Transporter associated with antigen processing) proteins are involved in
Bare_lymphocyte_syndrome
Protein
Membrane-associated transporter protein (MATP), also known as solute carrier family 45 member 2 (SLC45A2) or melanoma antigen AIM1, is a protein that in
Membrane-associated transporter protein
Membrane-associated_transporter_protein
assembly consists of seven subunits, including the transporters associated with antigen processing (TAP1 and TAP2 – jointly referred to as TAP), the oxidoreductase
Peptide-loading_complex
Cell surface proteins, part of the adaptive immune system
of MHC molecules, which is to bind an antigen derived from self-proteins, or from pathogens, and bring the antigen presentation to the cell surface for
Major histocompatibility complex
Major_histocompatibility_complex
Study of the role of the immune system in cancer
antigen presentation pathway, what leads into down-regulation of tumor antigen presentations. Defects are for example in transporter associated with antigen
Cancer_immunology
Subsystem of the immune system
Lankat-Buttgereit, Brigitte; Tampé, Robert (2002-01-01). "The Transporter Associated With Antigen Processing: Function and Implications in Human Diseases". Physiological
Adaptive_immune_system
Protein-coding gene in the species Homo sapiens
proteasome. Upon transport into the ER lumen by the transporter associated with antigen processing (TAP), these peptides bind to a peptide binding groove
HLA-E
Species of virus
interference with MHC class I antigen presentation on the cell surface, by blocking the transporter associated with antigen processing (TAP) induced
Herpes_simplex_virus
Main transmembrane structural unit of ATP-binding cassette transporter proteins
"Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing". EMBO J. 20 (17): 4964–72. doi:10.1093/emboj/20.17
Transmembrane domain of ABC transporters
Transmembrane_domain_of_ABC_transporters
Vaccine containing nucleic acids
are imported into the endoplasmic reticulum via the transporter associated with antigen processing, allowing them to bind to MHCI-molecules that are subsequently
Genetic_vaccine
Openings in nuclear envelope of eukaryotic cells
complex to spliced messages, serving as an adapter for Transporter associated with antigen processing (TAP), a low-affinity RNA-binding protein. However,
Nuclear_pore_complex
Protein-coding gene in the species Homo sapiens
TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2. The membrane-associated protein encoded by this gene is a member of the
TAP2
Protein found in humans
4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene. SLC3A2 comprises the
4F2 cell-surface antigen heavy chain
4F2_cell-surface_antigen_heavy_chain
Mammalian protein found in humans
complex to the transporter associated with antigen processing (TAP) complex. This association prepares the MHC class I for binding an antigen for presentation
Calnexin
Protein-coding gene in humans
Suita N, Maeda M (2003). "Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing
ABCB9
Cellular process
certain professional antigen-presenting cells (mostly dendritic cells) to take up, process and present extracellular antigens with MHC class I molecules
Cross-presentation
Soluble protein
with ERp57) takes over the job of chaperoning the MHC class I protein while the tapasin links the complex to the transporter associated with antigen processing
Calreticulin
Protein-coding gene in the species Homo sapiens
the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing". Journal of Immunology. 158 (5): 2236–2241
SEC14L2
Protein-coding gene in humans
2005). "Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome". Molecular
ABCB5
Protein complex on the surface of T cells that recognizes antigens
recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The binding between TCR and antigen peptides is of relatively
T-cell_receptor
Plasma membrane found in gram-negative bacteria
independent transport systems, namely, the O-antigen transporter Wzx (RfbX) and the ATP binding cassette (ABC) transporter MsbA that flips the lipid A-core moiety
Bacterial_outer_membrane
Distinct variation within a species of bacteria or virus or among immune cells
antibodies is the O antigen. Variation in the O antigen can be caused by genetic differences in the biosynthetic pathway or the transporter used to move the
Serotype
Protein-coding gene in the species Homo sapiens
lumen by the transporter associated with antigen processing (TAP) and is presented on the cell surface on H2-Db major histocompatibility antigen I (MHC I)
HM13
Protein-coding gene in the species Homo sapiens
this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular
ABCG2
Protein found in humans
also known as Multidrug resistance-associated protein 2 (MRP2) and canalicular multispecific organic anion transporter 1 (cMOAT). MRP2 is a member of the
ATP-binding cassette sub-family C member 2
ATP-binding_cassette_sub-family_C_member_2
Oxygen-delivering blood cell and the most common type of blood cell
cycle.; Kidd antigen protein – urea transporter; RHAG – gas transporter, probably of carbon dioxide, defines Rh Blood Group and the associated unusual blood
Red_blood_cell
Protein-coding gene in the species Homo sapiens
binding of ILT2 and ILT4. HLA-F can associate with TAP (transporter associated with antigen processing) and with the multimeric complex involved in peptide
HLA-F
Class of molecules found in the outer membrane of Gram-negative bacteria
molecules consisting of three parts: an outer core polysaccharide termed the O-antigen, an inner core oligosaccharide and lipid A (from which toxicity is largely
Lipopolysaccharide
Some of these antigens are ubiquitously expressed in nucleated male cells, and the presence of these antigens has been associated with a greater risk
Minor histocompatibility antigen
Minor_histocompatibility_antigen
Protein-coding gene in the species Homo sapiens
subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized
ABCB6
Component of MHC class I molecules
function is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the
Beta-2_microglobulin
Protein found in humans
proteasomes which can be applied as clinical biomarkers. During the antigen processing for the major histocompatibility complex (MHC) class-I, the proteasome
PSMB8
B-Cell Maturation Antigen for Previously Treated Multiple Myeloma" at ClinicalTrials.gov "Celgene narrows pioneering CAR-T collaboration with bluebird bio
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Combination in the membranes of cells
kinase Csk to the raft associated protein CBP. Csk may then suppress the Src-family kinases through phosphorylation. B cell antigen receptor (BCR) is a complex
Lipid_raft
Protein-coding gene in the species Homo sapiens
RHAG gene can cause stomatocytosis. The Rh blood group antigens (MIM 111700) are associated with human erythrocyte membrane proteins of approximately 30
RHAG
Sex chromosome present in both sexes in the XY and X0 sex-determination systems
A, 8 MAGED4B: encoding protein Melanoma-associated antigen D4 MAGT1: encoding protein Magnesium transporter protein 1 MAGED4: encoding protein MAGE family
X_chromosome
Protein found in humans
UDP-galactose transporter messenger RNA in human colon cancer tissues and its implication in synthesis of Thomsen-Friedenreich antigen and sialyl Lewis
UDP-galactose_translocator
Human genetic adaptation
falciparum. Human leucocyte antigen (HLA) polymorphisms common in West Africans but rare in other racial groups are associated with protection from severe
Human genetic resistance to malaria
Human_genetic_resistance_to_malaria
M, Kirk CJ, Groettrup M (February 2013). "The immunoproteasome in antigen processing and other immunological functions". Current Opinion in Immunology
Immunoproteasome
Protein-coding gene in the species Homo sapiens
transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter
Natural resistance-associated macrophage protein 1
Natural_resistance-associated_macrophage_protein_1
Cytoplasmic body from the fusion of the phagosome and lysosome
phagolysosome serves multiple cellular functions. In immune cells, this process is crucial for antigen presentation, enabling the cell to communicate information about
Phagolysosome
Protein-coding gene in humans
resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine
ABCB4
synthase of the mitochondrial respiratory chain and of the transporter associated with antigen processing (TAP). Research on RNA structure and function led to
Cluster of Excellence Frankfurt Macromolecular Complexes
Cluster_of_Excellence_Frankfurt_Macromolecular_Complexes
Mammalian protein found in Homo sapiens
Shayakul C, Alper SL (2004). "Defects in processing and trafficking of the AE1 Cl−/HCO3− exchanger associated with inherited distal renal tubular acidosis"
Band 3 anion transport protein
Band_3_anion_transport_protein
Mammalian protein found in Homo sapiens
is a determinant for the Ok blood group system. There are three known antigens in the Ok system; the most common being Oka (also called OK1), OK2 and
Basigin
Protein-coding gene in the species Homo sapiens
Sodium-dependent phosphate transport protein 2b (NaPi2b) is a tumor-associated antigen. upifitamab rilsodotin, an antibody-drug conjugate (ADC) targeting
Sodium-dependent phosphate transport protein 2B
Sodium-dependent_phosphate_transport_protein_2B
Protein-coding gene in the species Homo sapiens
GAD (glutamic acid decarboxylase), IA-2 (insulinoma-associated protein 2), and ZnT8 (zinc transporter of islet beta cells). However, it is not clear if
PTPRN
Protein-coding gene in the species Homo sapiens
et al. (2004). "Identification and characterization of a Kidd antigen/UT-B urea transporter expressed in human colon". Am. J. Physiol., Cell Physiol. 287
Urea_transporter_1
Family of proteins
are usually not mentioned: antigenic peptides are generated in proteasome, transported into ER through protein transporter TAP and loaded onto MHCI, which
Heat_shock_protein
Type of brain cell
these express glutamate transporters (EAAT1/SLC1A3 and EAAT2/SLC1A2) and respond to synaptic release of glutamate by transporter currents. The function
Astrocyte
Protein-coding gene in the species Homo sapiens
Rh blood group, D antigen also known as Rh polypeptide 1 (RhPI) or cluster of differentiation 240D (CD240D) is a protein that in humans is encoded by
RHD_(gene)
Protein found in humans
Zinc transporter SLC39A7 (ZIP7), also known as solute carrier family 39 member 7, is a transmembrane protein that in humans is encoded by the SLC39A7
Zinc_transporter_SLC39A7
Quaternary-structure protein with 4 subunits
MHC tetramers can be used in tetramer assays, to quantify numbers of antigen-specific T cells (especially CD8+ T cells). MHC tetramers are based on
Tetrameric_protein
Protein-coding gene in the species Homo sapiens
the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene". Biochemical and Biophysical
ABCA7
Protein-coding gene in humans
well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur
ABCB7
there is at least some host-independent, stochastic element to the process. The antigenic variation causes cyclical waves of parasitemia, which is one of
Variant_surface_glycoprotein
Chronic neurological sleep disorder
hypocretin peptides. Genes associated with narcolepsy mark the particular HLA heterodimer (DQ0602) involved in presentation of these antigens and modulate expression
Narcolepsy
Protein-coding gene in the species Homo sapiens
F, Jack DL, Paulsen IT, et al. (1999). "New glycoprotein-associated amino acid transporters". J. Membr. Biol. 172 (3): 181–92. doi:10.1007/s002329900595
Large neutral amino acids transporter small subunit 1
Large_neutral_amino_acids_transporter_small_subunit_1
Feeling of pain from stimuli which do not normally elicit pain
Haas AH, Brouwer N, Boddeke HW, Biber K (2006). "Challenge with innate and protein antigens induces CCR7 expression by microglia in vitro and in vivo"
Allodynia
Protein-coding gene in the species Homo sapiens
acid. Mutations in the SLC36A2 gene are associated with Iminoglycinuria. Proton coupled amino acid transporter GRCh38: Ensembl release 89: ENSG00000186335
Proton-coupled amino acid transporter 2
Proton-coupled_amino_acid_transporter_2
Human chromosome
protein DPYS: dihydropyrimidinase EBAG9: Estrogen receptor binding site associated antigen 9 ENTPD4: encoding protein Ectonucleoside triphosphate diphosphohydrolase
Chromosome_8
Brain parts regulating brain blood flow
(HIF-1α), which in turn upregulates pro-inflammatory cytokines, glucose transporters, and pro-angiogenic factors. Neuronal injury is often preceded by the
Neurovascular_unit
Human protein and coding gene
co-localize with nucleotide oligomerization domain-like receptors (NLRs) and caspase-1. Unlike isoform 1, isoform 2 is involved in direct IL-1β processing regulation
PYCARD
Mammalian protein found in Homo sapiens
certain tumor-associated cells, including tumor-infiltrating macrophages and dendritic cells, where it helps process IgG-bound antigens for presentation
Neonatal fragment crystallizable receptor
Neonatal_fragment_crystallizable_receptor
Protein found in humans
the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene". Biochem. Biophys. Res. Commun
HMHA1
Protein family
found in the Transporter Classification Database. This classification is based on sequence similarity which also happens to coincide with functional and
Calcium release activated channel
Calcium_release_activated_channel
Protein-coding gene in the species Homo sapiens
kDa glycoprotein of the human erythrocyte membrane associated with Rh (rhesus) blood-group antigen expression". Biochem. J. 287 (1): 223–8. doi:10.1042/bj2870223
RHCG
Protein with oligosaccharide modifications
directly with antigens. molecules of the major histocompatibility complex (or MHC), which are expressed on the surface of cells and interact with T cells
Glycoprotein
Protein-coding gene in humans
patients with Chédiak–Higashi syndrome. In the presence of growth factor, growth factor inhibition of mammalian Rab7 had no effect on nutrient transporter expression
RAB7A
Protein-coding gene in the species Homo sapiens
medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28". The Biochemical Journal. 359
AP2M1
Protein-coding gene in the species Homo sapiens
AP2S1 gene. One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is
AP2S1
Carbohydrate tumor antigen
an N-glycolyl variant of the ganglioside GM3 and an established tumor antigen. In humans, the typical GM3 is synthesized from lactosylceramide substrate
Neu5Gc-GM3
Protein-coding gene in the species Homo sapiens
involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may
ABCB8
Protein found in humans
flanked by long terminal repeats (LTRs) and is preceded by ERVW1 gag (Group AntiGen) and pol (POLymerase) within the provirus, both of which contain nonsense
Syncytin-1
Autoimmune disease resulting in skeletal muscle weakness
leukocyte antigen haplotypes are associated with increased susceptibility to myasthenia gravis and other autoimmune disorders. Relatives of people with myasthenia
Myasthenia_gravis
Protein found in humans
amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene. Heterodimeric amino acid transporter Solute carrier
Large neutral amino acids transporter small subunit 2
Large_neutral_amino_acids_transporter_small_subunit_2
Mammalian protein found in humans
Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (Cluster of Differentiation 66a), is a
CEACAM1
Medical imaging technique
is growing interest in using a PET scan with radionuclides delivered via prostate-specific membrane antigen (PSMA) targeting ligand, a strategy which
Positron_emission_tomography
Rod-shaped, gram-negative bacterium
serotype, which is based on major surface antigens (O antigen: part of lipopolysaccharide layer; H: flagellin; K antigen: capsule), e.g. O157:H7). It is, however
Escherichia_coli
Human chromosome
acrosome membrane-associated protein 3 SPAG5: encoding protein Sperm-associated antigen 5 SPMAP1: encoding protein Sperm microtubule associated protein 1 ST6GALNAC1:
Chromosome_17
Cell membrane organelle
Parameswaran; Pandey, Ashok (2022). "Enzymes in seafood processing". Value-Addition in Food Products and Processing Through Enzyme Technology. pp. 189–204. doi:10
Lysosome
Basic unit of life forms
that could accidentally damage its structure or interfere with its processing. During processing, DNA is transcribed, or copied into a special RNA, called
Cell_(biology)
Human chromosome
SPATS2L: spermatogenesis associated, serine-rich 2-like protein SSB: Sjögren syndrome antigen B SSFA2: Sperm-specific antigen 2 STK11IP: encoding protein
Chromosome_2
Protein-coding gene in humans
B-cell receptor-associated protein 31 is a protein that in humans is encoded by the BCAP31 gene. BCAP31 has been shown to interact with: APP, BCL2L1, BCL2
BCAP31
Cell surface receptor found in humans
presents components of an antigen there, as the result of which specific antibodies are formed that recognize precisely that antigen. These newly formed antibodies
Toll-like_receptor_2
Biochemical assembly for transporting hydrophobic lipid molecules
drivers or modulators of atherosclerosis. Many enzymes, transporters, structural proteins, antigens, adhesins, and toxins are sometimes also classified as
Lipoprotein
Species of bacterium
variable domain of the κ immunoglobulin light chains independently of antigen specificity, distinguishing it from Protein A of Staphylococcus aureus
Finegoldia_magna
Species of bacteria
the epithelial–mesenchymal transition associated with the progression of tumors. CagA (cytotoxin-associated antigen A) is a major virulence factor for H
Helicobacter_pylori
Biological processes that may contribute to autism
left hemisphere is associated with processing information related to details whereas the right hemisphere is associated with processing information in a
Mechanism_of_autism
Rare neurodegenerative disease
their target RNA transcripts do not undergo normal processing. Other RNA metabolism genes associated with ALS include ANG, SETX, and MATR3. C9orf72 is the
ALS
Protein-coding gene in the species Homo sapiens
Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci
AP1B1
Form of arthritis causing swollen joints
of the human leukocyte antigen B (HLA-B) is strongly associated with severe cutaneous adverse reactions during treatment with allopurinol and is most
Gout
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TRANSPORTER ASSOCIATED-WITH-ANTIGEN-PROCESSING
TRANSPORTER ASSOCIATED-WITH-ANTIGEN-PROCESSING
TRANSPORTER ASSOCIATED-WITH-ANTIGEN-PROCESSING
TRANSPORTER ASSOCIATED-WITH-ANTIGEN-PROCESSING
TRANSPORTER ASSOCIATED-WITH-ANTIGEN-PROCESSING
TRANSPORTER ASSOCIATED-WITH-ANTIGEN-PROCESSING
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