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Analytical technique to study proteins
Activity-based proteomics, or activity-based protein profiling (ABPP) is a chemoproteomic strategy that employs modular probes to directly assess the functional
Activity-based_proteomics
Large-scale study of proteins
Proteomics is the large-scale study of proteins. The proteome is the entire set of proteins produced or modified by an organism or system. Proteomics
Proteomics
American chemical biologist
Institute in La Jolla, California. Considered a co-inventor of activity-based proteomics and a substantial contributor to research on the endocannabinoid
Benjamin_Cravatt_III
Scientific discipline
work to improve proteomics through the development of enrichment strategies, chemical affinity tags, and new probes. Samples for proteomics often contain
Chemical_biology
Organic compound with at least one covalent carbon–phosphorus bond
P7(CH3)3. Activity-based proteomics—A branch of biochemistry that often relies on organophosphorus probes to interrogate enzyme activities Bihar school
Organophosphorus_chemistry
Activity-based proteomics Alpha/beta hydrolase fold Amide Enzyme Ester List of enzymes Thioester Simon GM, Cravatt BF (April 2010). "Activity-based proteomics
Serine_hydrolase
in the process of prokaryotic transcription. The basic unit of activity-based proteomics is the probe, which typically consists of two elements: a reactive
Affinity_label
Molecule that blocks enzyme activity
portal Activity-based proteomics – a branch of proteomics that uses covalent enzyme inhibitors as reporters to monitor enzyme activity. Antimetabolite – an
Enzyme_inhibitor
Study of biochemical processes in an individual cell
subcellular analysis refer to the study of genomics, transcriptomics, proteomics, metabolomics, and cell–cell interactions at the level of an individual
Single-cell_analysis
Techniques used to study protein–small molecule interactions
required to detect drug-protein interactions. Activity-based protein profiling (ABPP, also activity-based proteomics) is a technique that was developed to monitor
Chemoproteomics
Suffix in biology
emerging field of biological research at the intersection of proteomics and genomics. Proteomics data used for gene annotations. Structural genomics: Study
Omics
Biomolecule consisting of chains of amino acid residues
sets defines the field of proteomics, named by analogy to the related field of genomics. Key experimental techniques in proteomics include 2D electrophoresis
Protein
American computer scientist (born 1956)
Oncology Laboratory at USC. He co-founded Applied Proteomics (API) with David Agus to make proteomics-based biomarker discovery practical. Hillis and his
Danny_Hillis
American scientist
"Stephen K. Burley, M.D., D.Phil. | Center for Integrative Proteomics Research". proteomics.rutgers.edu. Archived from the original on 10 March 2016. Retrieved
Stephen_K._Burley
Sub-discipline of biology
by Positional Proteomics. ACS Chem. Biol. 10, 1754-1764 (2015). Eckhard U., Marino G., Butler G. S., Overall C. M. Positional proteomics in the era of
Degradomics
American clinical diagnostics company
companies, focusing on proteomic data. In 2019, SomaLogic entered into a new 10-year agreement with Novartis to use the SomaScan proteomics technology in drug
SomaLogic
Topics referred to by the same term
photoreactive warheads, reactive functional groups in probes used for activity-based proteomics Electrophilic warhead, the bond-forming functional group in targeted
Warhead_(disambiguation)
Mass spectrometry proteomic analysis software suite
PRM data with various workflows. PEAKS Studio is a proteomics software program for bottom-up proteomics data collected by LC-MS and MS/MS designed for peptide
PEAKS
Provisioner of scientific consumables, equipment, and services
partnered with the UK Biobank Pharma Proteomics Project (UKB-PPP) to support the world’s largest human proteomics study. Using the Olink Explore platform
Thermo_Fisher_Scientific
Biotech company
RNA, PNA). In 2002, Eurogentec acquired Wita Proteomics, a company specialized in proteomics services, based in Berlin (Germany). A few months later, Eurogentec
Eurogentec
Protein detection method
plasma. The method is used in the research field of proteomics, specifically affinity proteomics, where in one searches for differences in the abundance
Proximity_extension_assay
Pharmaceutical compound
been screened, including the oxytocin receptor. Microarray and activity-based proteomic profiling are currently being conducted to better elucidate the
KNX-100
example for using droplet-based microfluidics was a flow-through chip reactor for miniaturized PCR . Interest in droplet-based microfluidics systems has
Droplet-based_microfluidics
Bioinformatics method
enriched or depleted groups of genes. Transcriptomics technologies and proteomics results often identify thousands of genes, which are used for the analysis
Gene_set_enrichment_analysis
Device for tracking proteins
"Miniaturized, Microarray-Based Assays for Chemical Proteomic Studies of Protein Function". Chemical Genomics and Proteomics. Methods in Molecular Biology
Protein_microarray
Academic journal
2024: spatial proteomics". Nature Methods. 22 (1): 1. 2025. doi:10.1038/s41592-024-02565-3. "Method of the Year 2025: electron microscopy-based connectomics"
Nature_Methods
Branch of proteomics
Phosphoproteomics is a branch of proteomics that identifies, catalogs, and characterizes proteins containing a phosphate group as a posttranslational modification
Phosphoproteomics
Proteins present in blood serum
more recent times this research has been performed using LC-tandem MS based proteomics. The normal laboratory value of serum total protein is around 7 g/dL
Plasma_protein
Swiss researcher and academic
M., Ploegh, H. L., & Ovaa, H. (2004). Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like
Benedikt_Kessler
Set of chemical reactions in organisms
in its activity have on the overall rate of the pathway (the flux through the pathway). For example, an enzyme may show large changes in activity (i.e.
Metabolism
German physicist and biochemist (born 1959)
spectrometry-based proteomics: The peptide sequence tag approach developed at the EMBL was one of the first methods for the identification of peptides based on
Matthias_Mann
DNA repair process
glycosylase activity, whereas bifunctional glycosylases also possess AP lyase activity. Therefore, bifunctional glycosylases can convert a base lesion into
Base_excision_repair
Tail region of an antibody
immunoglobulin glycosylation by LC-ESI-MS of glycopeptides and oligosaccharides". Proteomics. 8 (14): 2858–2871. doi:10.1002/pmic.200700968. PMID 18655055. S2CID 22821543
Fragment crystallizable region
Fragment_crystallizable_region
Measurable indicator
using basic and acceptable platforms such as genomics and proteomics. Many genomic and proteomics techniques are available for biomarker discovery and a
Biomarker_(medicine)
Protein-coding gene in the species Homo sapiens
Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach
Serrate RNA effector molecule homolog
Serrate_RNA_effector_molecule_homolog
approaches: a digestion-free, top-down method and bottom-up proteomics. Top-down proteomics is seldom used to analyse ancient proteins due to analytical
Ancient_protein
Genome regions affecting protein levels
of the growing field of proteomics. Scientists who study proteomics use techniques like mass spectrometry and affinity-based assays to quantify the number
Protein quantitative trait loci
Protein_quantitative_trait_loci
Excessive fat buildup in the liver with other metabolic disease
biomarkers of MASLD, NAFL, and MASH involves lipidomics, medical imaging, proteomics, blood tests, and scoring systems. According to a review, proton density
Metabolic dysfunction–associated steatotic liver disease
Metabolic_dysfunction–associated_steatotic_liver_disease
Biomarker Biomarker (medicine) Clinical chemistry Clinical proteomics Drug discovery Genomics Proteomics Secretomics Endophenotype Massive parallel sequencing
Biomarker_discovery
Species of venomous snake
Identification of key toxin targets for antivenom development". Journal of Proteomics. 119: 126–142. Bibcode:2015JProt.119..126L. doi:10.1016/j.jprot.2015.02
Black_mamba
Origin and diversification of snake venom through geologic time
Comparative proteomics of the venoms of terrestrial Toxicocalamus longissimus and marine Hydrophis cyanocinctus". Journal of Proteomics. 75 (13): 4091–4101
Evolution_of_snake_venom
Impulse transmission between neurons
"Neuronal porosome proteome: Molecular dynamics and architecture". Journal of Proteomics. 75 (13): 3952–62. doi:10.1016/j.jprot.2012.05.017. PMC 4580231. PMID 22659300
Neurotransmission
Medical model that tailors medical practices to the individual patient
"Recent mass spectrometry-based proteomics for biomarker discovery in lung cancer, COPD, and asthma". Expert Review of Proteomics. 14 (4): 373–386. doi:10
Personalized_medicine
Study of all proteins in an environment
Metaproteomics (also community proteomics, environmental proteomics, or community proteogenomics) is an umbrella term for experimental approaches to study
Metaproteomics
Chemical compound
E; Ortega, M; Cazzoli, A (2007). "Food preservative based on propolis: Bacteriostatic activity of propolis polyphenols and flavonoids upon Escherichia
Galangin
Invention of new medications based on knowledge of a biological target
and Proteomics. 1844 (11): 2002–2015. doi:10.1016/j.bbapap.2014.07.006. PMID 25110827. Tollenaere JP (April 1996). "The role of structure-based ligand
Drug_design
Enzymes produced by fungi and secreted outside their cells
S2CID 4384243. Allison, S.D.; et al. (2007). "Soil enzymes: linking proteomics and ecological processes". In Hurst, CJ.; Crawford, RL.; Garland, JL.;
Fungal extracellular enzyme activity
Fungal_extracellular_enzyme_activity
American chemist (born 1974)
that capture distinct oxidation states. These advances transformed redox proteomics into a site-resolved, quantitative discipline and created new strategies
Kate_Carroll
Secretomics is a type of proteomics which involves the analysis of the secretome—all the secreted proteins of a cell, tissue or organism. Secreted proteins
Secretomics
Interdisciplinary science
technology suitable for a wide variety of applications including proteomics and cell-based assays. Microfluidic fuel cells can use laminar flow to separate
Microfluidics
Key enzyme of photosynthesis involved in carbon fixation
Jwa NS, Rakwal R (February 2009). "Rice proteomics: ending phase I and the beginning of phase II". Proteomics. 9 (4): 935–963. doi:10.1002/pmic.200800594
RuBisCO
Activation or suppression of the immune system to treat disease
Huang TC, Hsu CL, Tsai SR, Lee SC, et al. (February 2015). "Quantitative proteomics reveals middle infrared radiation-interfered networks in breast cancer
Immunotherapy
Group of venomous snakes from Asia
Petras, D.; Heiss, P.; Süssmuth, R. D.; Calvete, J. J. (2015). "Venom proteomics of Indonesian King Cobra, Ophiophagus hannah: Integrating top-down and
King_cobra
Protein molecule receiving signals for a cell
change in the electrical activity of a cell. For example, GABA, an inhibitory neurotransmitter, inhibits electrical activity of neurons by binding to
Receptor_(biochemistry)
Chronic multi-symptomatic pain disorder
SG, Bogdanos DP, Gika H, Goulis DG, Grammatikopoulou MG (July 2024). "Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational
Fibromyalgia
Antibiotic and antiprotozoal medication
Metronidazole-Resistant Giardia intestinalis Lines by Comparative Transcriptomics and Proteomics". Frontiers in Microbiology. 13 834008. doi:10.3389/fmicb.2022.834008
Metronidazole
Class of enzymes
disulfide isomerase". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1699 (1–2): 35–44. doi:10.1016/j.bbapap.2004.02.017. PMID 15158710. Gruber
Protein_disulfide-isomerase
Research center in Baton Rouge, Louisiana
and physicians with specialties such as molecular biology, genomics and proteomics, neuroanatomy, exercise physiology, biochemistry, psychology, endocrinology
Pennington Biomedical Research Center
Pennington_Biomedical_Research_Center
Peptide hormone and neuropeptide
aminopeptidases". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1751 (1): 9–18. doi:10.1016/j.bbapap.2004.09.011. PMID 16054015. Nomura
Oxytocin
Organisms capable of living in extreme environments
Acidithiobacillus ferrooxidans: a high throughput proteomics analysis". Molecular & Cellular Proteomics. 6 (12): 2239–51. doi:10.1074/mcp.M700042-MCP200
Extremophile
Canadian cell biologist
Canadian National Proteomics Network Prix D’Excellence Award for Outstanding Contribution and Leadership to the Canadian Proteomics Community (2010).
John_J._M._Bergeron
Chemist
in proteomics and the study of Alzheimer's disease, sepsis, and aging. She has developed a novel multiplexing strategy for quantitative proteomics called
Renã_A._S._Robinson
Non-soluble proteins with elongated or sheet-like structures
generally soluble in water, performing dynamic functions like enzymatic activity or transport. Such proteins serve protective and structural roles by forming
Fibrous_protein
Protein in wheat and other cereals
database to support development of proteomics methods for determination of gluten in gluten-free foods". Journal of Proteomics. 163: 67–75. doi:10.1016/j.jprot
Gliadin
Discredited academic publishing company
PhD student. It started its first open-access journal, the Journal of Proteomics & Bioinformatics, in 2008. In 2012, OMICS Group had more than 200 journal
OMICS_Publishing_Group
Data mining technique
vicinity of amino acids targeted for post-translational modifications". Proteomics. 8 (10): 1954–1958. doi:10.1002/pmic.200700657. PMID 18491291. S2CID 22362167
Sequential_pattern_mining
Rod-shaped, gram-negative bacterium
bacterial protein histidine phosphorylation revealed by mass spectrometry-based proteomics". Nature Methods. 15 (3): 187–190. doi:10.1038/nmeth.4580. hdl:1874/362159
Escherichia_coli
Santana L, Ubeira FM, Uriarte E (February 2008). "Proteomics, networks and connectivity indices". Proteomics. 8 (4): 750–78. doi:10.1002/pmic.200700638. PMID 18297652
Topological_index
Enzymes which degrade or break chitin
lungkine and chitinase levels in allergic airway inflammation: a proteomics approach". Proteomics. 5 (11): 2799–807. doi:10.1002/pmic.200401169. PMID 15996009
Chitinase
substrates (TAILS) is a method in quantitative proteomics that identifies the protein content of samples based on N-terminal fragments of each protein (N-terminal
Terminal amine isotopic labeling of substrates
Terminal_amine_isotopic_labeling_of_substrates
Organization founded in 1906
Cellular Proteomics 6:951, 2007. Peipei Ping, Rolf Apweiler and John Bergeron, MCP and HUPO: An Era of New Partnership, Molecular & Cellular Proteomics 6:951-952
American Society for Biochemistry and Molecular Biology
American_Society_for_Biochemistry_and_Molecular_Biology
using several techniques including microarray analysis;[citation needed] Proteomics, studies the proteins that are a product of the genes. It covers how protein
Foodomics
Group of antibiotics derived from fungi
C (April 2019). "Proteomics and Penicillium chrysogenum: Unveiling the secrets behind penicillin production". Journal of Proteomics. 198. Elsevier: 119–31
Penicillin
Database of protein domains, families and functional sites
detection (see sequence motif, PROSITE patterns). It is part of the ExPASy proteomics analysis servers. The database ProRule builds on the domain descriptions
PROSITE
Protein
produced by the cyanobacterium Nostoc ellipsosporum that displays virucidal activity against several viruses, including human immunodeficiency virus (HIV).
Cyanovirin-N
Scientific study of life
of biology that seeks to understand the molecular basis of biological activity in and between cells. It is centered largely on the study of nucleic acids
Biology
Statement about a future event
such as genomics, proteomics, and cytomics, the most fundamental way to predict future disease is based on genetics. Although proteomics and cytomics allow
Prediction
Theory of a quantum origin of consciousness
elicit region-specific changes in protein expression in mammalian brain". Proteomics. 8 (14): 2983–2992. doi:10.1002/pmic.200800057. ISSN 1615-9853. PMID 18655074
Orchestrated objective reduction
Orchestrated_objective_reduction
Mass spectrometry software
offers subscription-based access to the SIRIUS web services for commercial users. SIRIUS is not suitable for analyzing proteomics MS data. The SIRIUS
SIRIUS_(software)
Species of bacterium
Qing; Zhang, Nan; Shen, Qirong; Zhang, Ruifu (2014-12-05). "Comparative Proteomics Analysis of Bacillus amyloliquefaciens SQR9 Revealed the Key Proteins
Bacillus_amyloliquefaciens
American biologist (born 1938)
colleagues created the technological foundation for the study of genomics and proteomics by developing five groundbreaking instruments - the protein sequencer
Leroy_Hood
Computational technique of discovering new drugs
There are two broad categories of screening techniques: ligand-based and structure-based. Given a set of structurally diverse ligands that binds to a receptor
Virtual_screening
Class of drugs used to treat malignant tumors
targets for new targeted antineoplastic drugs are divided into genomics and proteomics. Currently, targeted antineoplastic drugs focus on two main types of driver
Antineoplastic
Scientific branch of chemistry
disorder (e.g., Li). Other areas of study include: metallomics, genomics, proteomics, diagnostic agents (e.g., MRI: Gd, Mn; X-ray: Ba, I) and radiopharmaceuticals
Medicinal_chemistry
Class of peptides that have antimicrobial activity
be bactericidal instead of bacteriostatic. In general the antimicrobial activity of these peptides is determined by measuring the minimal inhibitory concentration
Antimicrobial_peptides
Species of bacteria, cause of plague
reclassification would generate confusion. A comprehensive and comparative proteomics analysis of Y. pestis strain KIM was performed in 2006. The analysis focused
Yersinia_pestis
Species of centipede
centipede proteins have a major role in their clinical effects. Through proteomics, researchers had found that the venoms of S. monjiangica and S. mutilans
Chinese_red-headed_centipede
Italian molecular biologist
Zolla, Lello (2008). "Proteomics applied on plant abiotic stresses: Role of heat shock proteins (HSP)". Journal of Proteomics. 71 (4): 391–411. doi:10
Lello_Zolla
Macromolecular complex formed by two, usually non-covalently bound, macromolecules
Urea Concentrations." Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol. 1864, no. 7, 2016, pp. 755–765, https://doi.org/10.1016/j.bbapap
Protein_dimer
Family of insects
Repertoire of Blood-feeding Horsefly Salivary Glands". Molecular & Cellular Proteomics. 8 (9). Elsevier: 2071–2079. doi:10.1074/mcp.M900186-MCP200. PMC 2742439
Tabanidae
Compounds found in cannabis
reuptake inhibitor Abyadeh M, Gupta V, Paulo JA, et al. (September 2021). "A Proteomic View of Cellular and Molecular Effects of Cannabis". Biomolecules. 11
Cannabinoid
Computational and mathematical modeling of complex biological systems
Afkhami, Ehsan; Ramoni, Marco F. (2007). "Bayesian methods for proteomics". Proteomics. 7 (16): 2843–2855. doi:10.1002/pmic.200700422. ISSN 1615-9861
Systems_biology
Substance used to fill cavities in teeth
comparison to amalgam, the appearance of resin-based composite restorations is far superior. Resin-based composites are on the World Health Organization's
Dental_composite
Peptide hormone that stimulates growth
mucin-like biantennary disialylated tetrasaccharide attached at Thr-60". Proteomics. 9 (13): 3474–88. doi:10.1002/pmic.200800989. PMC 2904392. PMID 19579232
Growth_hormone
Edible fruit
with the flavonoid biosynthesis pathway in colorless strawberry mutant". Proteomics. 6 (5). Wiley: 1574–1587. doi:10.1002/pmic.200500469. PMID 16447153. "The
Strawberry
Area of the prefrontal cortex of primates
PMID 22789779. Scott E. Hemby; Sabine Bahn, eds. (2006). Functional genomics and proteomics in the clinical neurosciences. Amsterdam: Academic Press. ISBN 978-0-444-51853-8
Dorsolateral prefrontal cortex
Dorsolateral_prefrontal_cortex
Process of introducing a phosphate group on to a protein
phosphorylated proteins, which is a sub-branch of proteomics, combined with mass spectrometry-based proteomics, have been utilised to identify and quantify
Protein_phosphorylation
Genus of snakes
Praneetha; Chan, Yi Wei; Tan, Kae Yi; Tan, Choo Hock (2021). "Snake Venom Proteomics of Samar Cobra (Naja samarensis) from the Southern Philippines: Short
Naja
Italian biologist and academic
of mass spectrometry-based proteomics, the large-scale analysis of thousands of proteins from cells and tissues. Whilst proteomics offers the potential
Paola_Picotti
The Australasian Proteomics Society (APS) is a learned society formed in 2004 from the Lorne Proteomics Symposia (LPS) meetings. The APS was expanded to
Australasian Proteomics Society
Australasian_Proteomics_Society
ACTIVITY BASED-PROTEOMICS
ACTIVITY BASED-PROTEOMICS
Girl/Female
British, English
Based
Boy/Male
Biblical
Nativity, generation.
Boy/Male
Buddhist, Indian
Activity Like Lightning
Boy/Male
Indian
Activity, Defender
Girl/Female
Biblical
Conversion, captivity.
Boy/Male
Biblical
Turning captivity.
Girl/Female
Biblical
Nativity, generation.
Boy/Male
Tamil
Activity, Defender
Boy/Male
Muslim/Islamic
Brave
Boy/Male
Indian, Punjabi, Sikh
One who Loves Activity
Male
Egyptian
, the father of Hor-imhotep.
Boy/Male
Muslim/Islamic
Smiling
Boy/Male
Muslim
Smiling
Boy/Male
Afghan, African, Arabic, Australian, Chinese, Greek, Indian, Muslim
Brave
Boy/Male
Hindu
Philosophical verses, Activity, Dancer, Actress
Boy/Male
Arabic, Australian
Smiling
Boy/Male
Tamil
Philosophical verses, Activity, Dancer, Actress
Boy/Male
Afghan, Buddhist, Hindu, Indian, Marathi, Sanskrit
Hard Worker; Action or Activity
Boy/Male
Biblical
Nativity, generation.
Boy/Male
Hindu, Indian
Good Activity
ACTIVITY BASED-PROTEOMICS
ACTIVITY BASED-PROTEOMICS
Girl/Female
Arabic, Gujarati, Hindu, Indian, Kannada, Marathi, Muslim
Happy; Initiation; Cheerful; Beloved
Girl/Female
Hindu
Suswetha means good white. su means good and Swetha means white
Surname or Lastname
South German (Örgel)
South German (Örgel) : from Middle High German erkelin (a loanword from Latin arca ‘grape bin’, ‘vat’), hence probably a metonymic occupational name for someone who worked in a vineyard.English : variant spelling of Orgill.Jewish (Ashkenazic) : from German Orgel ‘organ’.
Girl/Female
German
Little and Womanly
Surname or Lastname
English
English : from a Germanic personal name, Aimeri, composed of the elements haim ‘home’ + rīc ‘power’. (The same elements constitute the etymology of Henry.) The name was introduced into England from France by the Normans. There has been some confusion with Emery.
Girl/Female
Sikh
One who worships God, Beauteous tranquillity
Girl/Female
Assamese, Bengali, Indian, Kannada
Leader
Boy/Male
Welsh
Son of Howell.
Girl/Female
Tamil
Durvisha | தà¯à®°à¯à®µà¯€à®·à®¾Â
Boy/Male
Indian
Famous sahabi of rasoolullah
ACTIVITY BASED-PROTEOMICS
ACTIVITY BASED-PROTEOMICS
ACTIVITY BASED-PROTEOMICS
ACTIVITY BASED-PROTEOMICS
ACTIVITY BASED-PROTEOMICS
n.
The state or quality of being inactive; inertness; as, the inactivity of matter.
a.
Alloyed with inferior metal; debased; as, base coin; base bullion.
a.
Deep or grave in sound; as, the base tone of a violin.
a.
Having a base, or having as a base; supported; as, broad-based.
n.
The quality of being sour; sourness; tartness; sharpness to the taste; as, the acidity of lemon juice.
n.
Same as Prison base.
a.
Reduced; lowered; restrained; as, to speak with bated breath.
a.
Not held by honorable service; as, a base estate, one held by services not honorable; held by villenage. Such a tenure is called base, or low, and the tenant, a base tenant.
n.
A rustic play; -- called also prisoner's base, prison base, or bars.
n.
A pie; baked food.
n.
The quality or condition of any substance which has no inclination to chemical activity; inactivity.
adv.
In an active signification; as, a word used actively.
n.
The state or quality of being active; nimbleness; agility; vigorous action or operation; energy; active force; as, an increasing variety of human activities.
adv.
Without activity; sluggishly.
imp. & p. p.
of Base
n.
Wearing, or protected by, bases.
n.
Abundant activity.
a.
Morally low. Hence: Low-minded; unworthy; without dignity of sentiment; ignoble; mean; illiberal; menial; as, a base fellow; base motives; base occupations.
n.
Strenuousness; activity.
pl.
of Activity