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Protein-coding gene in the species Homo sapiens
Cyclin-K is a protein that in humans is encoded by the CCNK gene. The protein encoded by this gene is a member of the transcription cyclin family. These
Cyclin_K
Group of proteins
Cyclins are proteins that control the progression of a cell through the cell cycle by activating cyclin-dependent kinases (CDK). Cyclins were originally
Cyclin
Class of enzymes
Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases involved in the regulation of the cell cycle. These enzymes function as
Cyclin-dependent_kinase
of a protein kinase, cyclin-dependent kinase (CDK), with a regulatory subunit, cyclin. Once cyclin-dependent kinases bind to cyclin, the formed complex
Cyclin-dependent kinase complex
Cyclin-dependent_kinase_complex
Protein family
Cyclin B is a member of the cyclin family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk
Cyclin_B
Protein-coding gene in humans
Cyclin-T1 is a protein that in humans is encoded by the CCNT1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose
Cyclin_T1
Member of the cyclin family
Cyclin E is a member of the cyclin family. Cyclin E binds to G1 phase Cdk2, which is required for the transition from G1 to S phase of the cell cycle
Cyclin_E
Protein family
Cyclin A is a member of the cyclin family, a group of proteins that function in regulating progression through the cell cycle. The stages that a cell passes
Cyclin_A
Member of the cyclin protein family
Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during
Cyclin_D
Class of chemical compounds
and other diseases. For instance, small molecule degraders of BCL6 and Cyclin K exploit both ligand-binding and PPI surfaces to drive the formation of
Molecular_glue
Protein-coding gene in the species Homo sapiens
G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. Cyclin B1 is a regulatory protein involved in mitosis. The gene
Cyclin_B1
Protein-coding gene in the species Homo sapiens
regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible
Cyclin-dependent_kinase_9
Protein found in humans
Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. The protein
Cyclin-dependent_kinase_2
Protein which inhibits cyclin-dependent kinase
A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein that inhibits the enzyme cyclin-dependent kinase (CDK) and
Cyclin-dependent kinase inhibitor protein
Cyclin-dependent_kinase_inhibitor_protein
Protein found in humans
Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. The CCND1 gene encodes the cyclin D1 protein. The human CCND1 gene is located on the
Cyclin_D1
Third subphase of interphase
threshold level of active cyclin-B1/CDK1 complex, also known as cyclin-B1/Cdc2 or the maturation promoting factor (MPF). Active cyclin-B1/CDK1 triggers irreversible
G2_phase
Enzyme found in humans
Cyclin dependent kinase 13 is an enzyme that in humans is encoded by the CDK13 gene. The protein encoded by this gene is a member of the cyclin-dependent
Cyclin-dependent_kinase_13
Protein-coding gene in the species Homo sapiens
Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene. It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and embryogenesis
Cyclin_A2
Human protein
Cyclin-dependent kinase 4 (CDK4), also known as cell division protein kinase 4, is an enzyme that is encoded by the CDK4 gene in humans. CDK4 is a member
Cyclin-dependent_kinase_4
Mammalian protein found in Homo sapiens
Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine
Cyclin-dependent_kinase_1
Cell cycle protein
G2/mitotic-specific cyclin-B3 is a protein encoded by the CCNB3 gene located on the X chromosome in humans. Cyclin B3 has features of both A type cyclins and B type
Cyclin_B3
Events leading to cell division
Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, et al. (October 2003). "Targets of the cyclin-dependent kinase Cdk1". Nature. 425 (6960): 859–864
Cell_cycle
Protein-coding gene in the species Homo sapiens
G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family
Cyclin_E1
Protein-coding gene in humans
G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2 gene. The protein encoded by this gene belongs to the highly conserved cyclin family
Cyclin_D2
Protein-coding gene in the species Homo sapiens
G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene. Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The
Cyclin_B2
Protein-coding gene in the species Homo sapiens
G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene. The protein encoded by this gene belongs to the highly conserved cyclin family
Cyclin_D3
Protein found in humans
encoded by the CDK6 gene. It is regulated by cyclins, more specifically by cyclin D proteins and cyclin-dependent kinase inhibitor proteins. The protein
Cyclin-dependent_kinase_6
Multi-protein structure
The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine
Cyclin_D/Cdk4
Protein kinase found in humans
Cyclin-dependent kinase 12 (or CDK12) is a protein kinase that in humans is encoded by the CDK12 gene. This enzyme is a member of cyclin-dependent kinase
Cyclin-dependent_kinase_12
Protein-coding gene in the species Homo sapiens
Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. Cyclin-dependent
Cyclin-dependent kinase inhibitor 1C
Cyclin-dependent_kinase_inhibitor_1C
Rare genetic disorder involving heart, facial and neurological features
by a mutation in the CDK13 gene, which encodes the protein cyclin-dependent kinase 13. Cyclin-dependent kinases are protein kinases, which are critical
CDK13-related_disorder
Protein-coding gene in the species Homo sapiens
Cyclin-T2 is a protein that in humans is encoded by the CCNT2 gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose
Cyclin_T2
The Cyclin E/Cdk2 complex is a structure composed of two proteins, cyclin E and cyclin-dependent kinase 2 (Cdk2). Similar to other cyclin/Cdk complexes
Cyclin_E/Cdk2
Protein
(alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that
P21
Protein-coding gene in the species Homo sapiens
Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene
Cyclin-dependent_kinase_7
Control mechanism in the eukaryotic cell cycle
largely determined by the activation of cyclin-dependent kinases by regulatory protein subunits called cyclins, different forms of which are produced at
Cell_cycle_checkpoint
German structural and chemical biologist
"The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K". Nature. 585 (7824): 293–297. doi:10.1038/s41586-020-2374-x. PMC 7486275
Nicolas_H._Thomä
Cell cycle checkpoint in eukaryotic organisms
specific cyclin-CDK complexes. CyclinB-CDK1 activity is specific to the G2/M checkpoint. Accumulation of cyclin B increases the activity of the cyclin dependent
G2-M_DNA_damage_checkpoint
Protein-coding gene in humans
Cyclin-C is a protein that in humans is encoded by the CCNC gene. The protein encoded by this gene is a member of the cyclin family of proteins. The encoded
Cyclin-C
Protein complex regulating transcription in eukaryotes
multiple forms of P-TEFb which contain Cdk9 and one of several cyclin subunits, cyclin T1, T2, and K. P-TEFb associates with other factors including the bromodomain
P-TEFb
Protein-coding gene in the species Homo sapiens
Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose
Cyclin_A1
British biochemist
studying fertilized sea urchin eggs in the early 1980s, Hunt discovered cyclin, a protein that cyclically aggregates and is depleted during cell division
Tim_Hunt
Protein-coding gene in humans
family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes
CDKN1B
Protein found in humans
Cyclin-dependent kinase 5 is a protein, and more specifically an enzyme, that is encoded by the Cdk5 gene. It was discovered 15 years ago,[when?] and it
Cyclin-dependent_kinase_5
proteins bind a wide range of G1/S and S-phase cyclin-CDK complexes including cyclin D-CDK4,6 and cyclin E-, A-CDK2 complexes. Traditionally it was assumed
CIP/KIP
Protein-coding gene in humans
CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. It is ubiquitously expressed
CDKN2A
Protein-coding gene in humans
Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene. The protein encoded by this gene is a member of the INK4
CDKN2C
Protein-coding gene in humans
whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino
CCNG2
Protein-coding gene in the species Homo sapiens
CDK3 can phosphorylate histone H1 and interacts with an unknown type of cyclin. GRCh38: Ensembl release 89: ENSG00000250506 – Ensembl, May 2017 "Human
Cyclin-dependent_kinase_3
Protein-coding gene in the species Homo sapiens
Cyclin-H is a protein in humans encoded by the CCNH gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members
Cyclin_H
Biological process
controlled by cyclin and cyclin-dependent kinases. The progression of interphase is the result of the increased amount of cyclin. As the amount of cyclin increases
Cell_division
regulated by cyclins binding their respective cyclin dependent kinases (Cdks) which then activate the kinases (Fisher, 2012). During G1, cyclin D is synthesized
Neuronal_cell_cycle
Protein-coding gene in humans
"Entrez Gene: CCNL2 cyclin L2". Human CCNL2 genome location and CCNL2 gene details page in the UCSC Genome Browser. Maruyama K, Sugano S (1994). "Oligo-capping:
CCNL2
Protein-coding gene in humans
Cyclin-I is a protein that in humans is encoded by the CCNI gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose
CCNI_(gene)
Replication of the nuclear genome without mitosis
(G1-S-G2-M) in which mitosis is circumvented entirely, due to modulation of cyclin-dependent kinase (CDK) activity. Examples of endoreduplication characterised
Endoreduplication
Protein-coding gene in humans
G2/mitotic-specific cyclin-F is a protein that in humans is encoded by the CCNF gene. This gene encodes a member of the cyclin family. Cyclins are important
CCNF
Protein-coding gene in the species Homo sapiens
protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK8 and cyclin C associate with the mediator complex and regulate
Cyclin-dependent_kinase_8
Spanish molecular biochemist (born 1949)
a receptor for neutotrophin-3." (1991). "Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors." (2000). "Toll-like Receptor-4 (TLR4)
Mariano_Barbacid
Biological factor
also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin–Cdk complex that was discovered first in frog eggs. It stimulates the mitotic
Maturation_promoting_factor
Enzyme found in humans
Cyclin-dependent kinase 14 is an enzyme that in humans is encoded by the CDK14 gene (previously PFTK1). PFTK1 has been shown to interact with SEPT8. GRCh38:
Cyclin-dependent_kinase_14
Quiescent stage of the cell cycle in which the cell does not divide
involves downregulation of cell cycle progression genes, such as cyclin A2, cyclin B1, cyclin E2, and survivin, and upregulation of genes involved in the regulation
G0_phase
Centrioles are nine triplets microtubules
Tarapore P, Fukasawa K (June 2001). "Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome
Centrosome_cycle
Mammalian protein found in humans
p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that
P16
Small bright red dome-shaped bump on the skin
MEK1 and cyclin E1. By inhibiting mir-424 in normal endothelial cells they could observe the same increased protein expression of MEK1 and cyclin E1 which
Cherry_angioma
Pharmaceutical compound
anticancer drug which acts as an inhibitor of BCL3-mediated expression of cyclin D1, which is important for the proliferation and metastasis of certain types
BCL3ANT
Cell-cycle regulatory complex
Slp1) inactivates CDK1 via ubiquitination of B-type cyclins. This results in activation of Cdh1(a.k.a. Fizzy-related, Hct1, Ste9, or Srw1), which interacts
Anaphase-promoting_complex
Type of blood cancer
surrounds normal germinal center follicles. MCL cells generally over-express cyclin D1 due to the t(11:14) translocation, a chromosomal translocation in the
Mantle_cell_lymphoma
Protein-coding gene in humans
Cyclin-dependent kinase 11B is an enzyme that in humans is encoded by the CDK11B gene (previously CDC2L1). This gene encodes a member of the p34Cdc2 protein
Cyclin-dependent_kinase_11B
Cell signaling pathway
transcriptional activity, preventing expression of S-phase entry genes including Cyclin E, Cyclin A2 and Emi1. ERK1/2 activation downstream of mitogen induced Ras signaling
MAPK/ERK_pathway
Protein-coding gene in the species Homo sapiens
M107466200. PMID 11572868. Lin X, Taube R, Fujinaga K, Peterlin BM (2002). "P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA". J. Biol
CTDSPL
Enzyme found in humans
Cyclin-dependent kinase 19 (or CDK19) is an enzyme that in humans is encoded by the CDK19 gene. The natural product cortistatin A is a potent and selective
Cyclin-dependent_kinase_19
Protein-coding gene in the species Homo sapiens
Cyclin-O is a protein that in humans is encoded by the CCNO gene. Cyclin O has been shown to interact with RPA2 and PCNA. GRCm38: Ensembl release 89: ENSMUSG00000042417
Cyclin_O
Protein-coding gene in humans
separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to
CDC20
Protein-coding gene in humans
Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene. The protein encoded by this gene is a member of the INK4
CDKN2D
Enzyme found in humans
Cyclin-dependent kinase 17 is an enzyme that in humans is encoded by the CDK17 gene (previously PCTK2). The protein encoded by this gene belongs to the
Cyclin-dependent_kinase_17
Protein-coding gene in humans
Cyclin-L1 is a protein that in humans is encoded by the CCNL1 gene. GRCh38: Ensembl release 89: ENSG00000163660 – Ensembl, May 2017 GRCm38: Ensembl release
CCNL1
Cell division producing haploid gametes
WEE1 as well as regulation of cyclin B levels facilitated by the anaphase-promoting complex (APC). CDK1 is regulated by cyclin B, whose synthesis peaks at
Meiosis
Enzyme
tyrosine phosphatases. By removing inhibitory phosphate residues from target cyclin-dependent kinases (Cdks), Cdc25 proteins control entry into and progression
Cdc25
Protein-coding gene in humans
Cyclin-dependent kinase 11A is an enzyme that in humans is encoded by the CDK11A gene (previously CDC2L2). This gene shares very high sequence identity
Cyclin-dependent_kinase_11A
Dependence of the state of a system on its history
verification] Here, Cdc2 (Cyclin-dependent kinase 1 or CDK1) is responsible for mitotic entry and exit such that binding of cyclin B forms a complex called
Hysteresis
Enzyme found in humans
Cyclin-dependent kinase 16 is an enzyme that in humans is encoded by the CDK16 gene (previously PCTK1). The protein encoded by this gene belongs to the
Cyclin-dependent_kinase_16
Fourth stage of mitosis and meiosis
B cyclin. B cyclin is marked with ubiquitin which flags it for destruction by proteasomes, which is required for the function of metaphase cyclin-dependent
Anaphase
Protein-coding gene in the species Homo sapiens
Eki T, Okumura K, Abe M, Kagotani K, Taguchi H, Murakami Y, Pan ZQ, Hanaoka F (April 1998). "Mapping of the human genes encoding cyclin H (CCNH) and the
MNAT1
Protein-coding gene in humans
Medicine. Endo Y, Fujita T, Tamura K, Tsuruga H, Nojima H (1996). "Structure and chromosomal assignment of the human cyclin G gene". Genomics. 38 (1): 92–5
CCNG1
Protein-coding gene in humans
Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4b is a protein that is encoded by the CDKN2B gene in
CDKN2B
Final stage of mitosis and meiosis
dephosphorylation of mitotic cyclin-dependent kinase (Cdk) substrates. The phosphorylation of the protein targets of M-Cdks (Mitotic Cyclin-dependent Kinases) drives
Telophase
Unspecialized biological cell that can become specialized
phases: Cyclin D and Cdk4/6 are active in the G1 phase, while Cyclin E and Cdk2 are active during the late G1 phase and S phase; and Cyclin A and Cdk2
Stem_cell
Protein-coding gene in the species Homo sapiens
Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ (2001). "Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase"
FBXW7
Mammalian protein found in Homo sapiens
repression of the D1 cyclin. Both MyoD and pRb are necessary for the repression of cyclin D1, but rather than acting directly on cyclin D1, they act on Fra-1
MyoD
Protein-coding gene in humans
Carroll JS, et al. (September 2009). "Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc". Molecular and Cellular Biology. 29 (17): 4623–4639
CHD8
Mammalian protein found in humans
example of E2F-regulated genes repressed by pRb are cyclin E and cyclin A. Both of these cyclins are able to bind to Cdk2 and facilitate entry into the
Retinoblastoma_protein
Protein-coding gene in the species Homo sapiens
stable complex with the cyclin A-CDK2 S-phase kinase. It specifically recognizes and promotes the degradation of phosphorylated cyclin-dependent kinase inhibitor
SKP2
Medical condition
of cancer. Cyclin D1 is a protein requisite for cell cycle progression and has been shown to be up-regulated in epithelioid sarcoma. Cyclin D1 is a regulator
Epithelioid_sarcoma
Enzyme catalyzing transfer of phosphate groups onto specific substrates
but CDKs must first bind to a cyclin protein in order to be active. Different combinations of specific CDKs and cyclins mark different parts of the cell
Kinase
Mammalian protein found in Homo sapiens
to interact with: Annexin A2 CAF-1 CDC25C CHTF18 Cyclin D1 Cyclin O Cyclin-dependent kinase 4 Cyclin-dependent kinase inhibitor 1C DNMT1 EP300 Establishment
Proliferating cell nuclear antigen
Proliferating_cell_nuclear_antigen
checkpoints. Many factors including cyclins, cyclin-dependent kinases (CDKs), ubiquitin ligases, inhibitors of cyclin-dependent kinases, and reversible
Mitotic_exit
Asexual reproduction without fertilization
Fertilization causes intracellular calcium oscillations and targeted degradation of cyclin B, a regulatory subunit of MPF; this permits the oocyte to proceed through
Parthenogenesis
Protein-coding gene in humans
Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH (November 1995). "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator". The
CDK5R2
Second subphase of interphase
for instance, cell growth induces accumulation of Cln3 cyclin, which complexes with the cyclin dependent kinase CDK2. The Cln3-CDK2 complex promotes transcription
S_phase
Type of protein
substrates of SCF complexes include: cyclin family proteins: Cyclin D, Cyclin E transcriptional regulators: Myc, E2f1, p130 cyclin-dependent kinase inhibitors
SCF_complex
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CYCLIN K
CYCLIN K
CYCLIN K
CYCLIN K
CYCLIN K
CYCLIN K
CYCLIN K
CYCLIN K
CYCLIN K
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