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Uniporter protein
Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that
GLUT1
Medical condition
GLUT1 deficiency syndrome, also known as GLUT1-DS, De Vivo disease or Glucose transporter type 1 deficiency syndrome, is an autosomal dominant genetic
GLUT1_deficiency
Family of monosaccharide transport proteins
subclasses. Class I comprises the well-characterized glucose transporters GLUT1-GLUT4. Class II comprises: GLUT5 (SLC2A5), a fructose transporter in enterocytes
Glucose_transporter
Medical condition
fluid glucose levels decrease is the representative symptom of those with GLUT1 deficiency syndrome. There are many health professionals who assess and
Toe_walking
Protein
a fetal skeletal muscle cell line, using a GLUT1 cDNA probe and shown to share 64.4% identity with GLUT1. Although GLUT3 was found to be expressed in
GLUT3
Transport protein
at a higher rate. An analysis of mRNA levels of GLUT1 and GLUT4 in cardiac muscles show that GLUT1 plays a larger role in cardiac muscles than it does
GLUT4
Episodes of involuntary movement triggered by exercise
contributor to familial PED is a mutation in the GLUT1 gene, SLC2A1, which codes for the transporter GLUT1, a protein responsible for glucose entry across
Paroxysmal exercise-induced dystonia
Paroxysmal_exercise-induced_dystonia
Glucose being transported from the blood into cells
most GLUTs facilitate glucose transport, HMIT is an exception. Among them, GLUT1-5 are the most extensively studied. However, for study GLUTs 1-4 or the
Glucose_uptake
Membrane protein involved in transportation
the cytoplasm of the erythrocyte and the blood plasma. GLUT1 is also found in brain tissues. GLUT1 can also transport mannose, galactose, and glucosamine
Membrane_transport_protein
Naturally produced monosaccharide
glucose can no longer diffuse out of the cell. The glucose transporter GLUT1 is produced by most cell types and is of particular importance for nerve
Glucose
Involuntary movements of parts of the body
different diseases and agents. It is a symptom of several diseases, including GLUT1 deficiency syndrome, Lesch–Nyhan syndrome, phenylketonuria, and Huntington
Choreoathetosis
Essential nutrient found in citrus fruits and other foods
import ascorbate across plasma membranes. The Hexose Transporter proteins GLUT1, GLUT3 and GLUT4 transfer only the oxydized dehydroascorbic acid (DHA) form
Vitamin_C
Delayed development in children
include genetic disorders such as Down syndrome, Fragile X syndrome and GLUT1 Deficiency Syndrome; childhood infections such as meningitis or encephalitis
Global_developmental_delay
American endocrinologist scientist
Patel; Joseph E Chen; et al. (June 11, 2013). "ATM and GLUT1-S490 phosphorylation regulate GLUT1 mediated transport in skeletal muscle". PLOS One. 8 (6)
Stanley_Andrisse
Genetically modified mouse used in gene research
they naturally mutate. For instance, erythrocyte-specific coexpression of GLUT1 with stomatin constitutes a compensatory mechanism in mammals that are unable
Knockout_mouse
Type of white blood cell
of tumor cells. Utilizing a mouse model, they[who?] identified that both Glut1 and glucose metabolism increased in TANs found within a mouse who possessed
Neutrophil
Class of membrane transport proteins
fourteen GLUT proteins. Class I GLUTs include GLUT1, one of the most studied isoforms, and GLUT2. GLUT1 is found in various tissues like the red blood
Uniporter
State of low muscle tone
Familial dysautonomia (Riley–Day syndrome) FG syndrome Fragile X syndrome GLUT1 deficiency syndrome Griscelli syndrome Type 1 (Elejalde syndrome) Holocarboxylase
Hypotonia
Situation where tumor cells have been deprived of oxygen
gradient. GLUT1 is the most abundantly expressed of the family thought to maintain basal glucose transport in almost all cell types. GLUT1 levels, in
Tumor_hypoxia
Physiological process in the kidney
2% Reabsorption (mmol/day) Concentration Apical transport proteins SGLT2 SGLT1 Basolateral transport proteins GLUT2 GLUT1 Other reabsorption features
Renal_glucose_reabsorption
Group of neurological disorders causing seizures
mitochondrial diseases, urea cycle disorders or glucose transporter type 1 (GLUT1) deficiency. These often present early in life and may be associated with
Epilepsy
Metabolite of vitamin C
mainly in specialized cells whereas the glucose transporters, most notably GLUT1, transport DHA in most cells, where recycling back to ascorbic acid generates
Dehydroascorbic_acid
Medical condition
lesions cause abnormal electrochemical discharges that result in seizures GLUT1 deficiency syndrome Anorexia nervosa, bulimia nervosa, and other eating
Cerebral_atrophy
Oxygen-delivering blood cell and the most common type of blood cell
Group; Aquaporin 1 – water transporter, defines the Colton Blood Group; Glut1 – glucose and L-dehydroascorbic acid transporter; MCT1 – Monocarboxylate
Red_blood_cell
Medical abnormality
hypoglycorrhacia]. Hypoglycorrhachia is associated with Glucose transporter type 1 GLUT1 deficiency syndrome (De Vivo disease). Perhaps a much more common example
Neuroglycopenia
Increased size of the lateral ventricles
frontal horns, is also important. Ventriculomegaly occurs in those with GLUT1 deficiency syndrome. Neuroinflammation Normal pressure hydrocephalus Hydrocephalus
Ventriculomegaly
Eye movement
eye–head movements, termed aberrant gaze saccades, are an early symptom of GLUT1 deficiency syndrome in infancy.[non-primary source needed] When the brain
Saccade
Abandoned metabolic and cardiovascular drug
colorectal cancer in mice by increasing inflammation and the expression of GLUT1 and SLC1A5. Acadesine GFT505 GW0742 Irisin Peroxisome proliferator-activated
GW501516
Specialised kidney cells
hypertension causes mesangial cells to stretch which causes induced expression of GLUT1 leading to increased cellular glucose. The repetition of stretching and
Mesangial_cell
Medical condition
breast, lung, or ovarian cancer in adults. Other considerations include GLUT1 Deficiency Syndrome, multiple sclerosis, toxins, medication effects (e.g
Opsoclonus
Series of biochemical reactions
glucose metabolism by increasing translocation of glucose transporters GLUT1 and GLUT4 to the plasma membrane, increasing hexokinase expression and phosphorylating
Akt/PKB_signaling_pathway
Species of virus
usage. HTLV-II entry in target cells is mediated by the glucose transporter GLUT1. HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization
Human_T-lymphotropic_virus_2
Protein-coding gene in the species Homo sapiens
glycolysis by increasing the expression of glucose transporters (such as GLUT1) and key glycolytic enzymes (like PDK1), thereby facilitating anaerobic
HIF1A
Protein-coding gene in the species Homo sapiens
complex binding is the missorting of Cl-MPR and glucose transporter 1, GLUT1, affecting TGN function and energy utilization. In PD, specifically, iron
VPS35
Series of events that restore integrity to damaged tissue after an injury
inducible factor (HIF) to transactivate angiogenic genes such as VEGF and GLUT1. Sprouted vessels can self-organise into luminal morphologies, and fusion
Wound_healing
patients. Depletion of regulatory T cells increases immune activation. Glut1 regulation is associated with the activation of CD4+ T cells, thus its expression
T-cell_depletion
Metabolism of fructose
into cells via insulin-sensitive pathways (insulin regulated transporters GLUT1 and GLUT4). Instead, fructose is taken in by GLUT5. Fructose in muscles
Fructolysis
Condition in which the head is small due to an underdeveloped brain
"Zellweger syndrome". Orphanet. Retrieved 2019-08-01. Reference, Genetics Home. "GLUT1 deficiency syndrome". Genetics Home Reference. Retrieved 2019-08-01. "Maternal
Microcephaly
Medical condition
palsy 343 G80 Rheumatoid arthritis 714 M05 Hyperkinetic Movement disorders GLUT1 deficiency syndrome E74.810 Attention-deficit hyperactivity disorder (with
Movement_disorder
Movement disorders with episodes of excessive restlessness
linked to mutations in the GLUT1 glucose transporter which can result in transient energy deficits in the basal ganglia. See GLUT1 deficiency syndrome. Diagnosis
Paroxysmal_dyskinesia
Transportation of substances via membrane
of the cell. One example of a uniport mediated transport protein is GLUT1. GLUT1 is a transmembrane protein, which means it spans the entire width of
Mediated_transport
Concept in genetics
Ehlers–Danlos syndrome Frontotemporal dementia caused by mutations in progranulin GLUT1 deficiency (DeVivo syndrome) Haploinsufficiency of A20 Haploinsufficiency
Haploinsufficiency
Species of fungus in the family Marasmiaceae
in degradation of protein substrates and the disappearance of the marker GLUT1 which indicates disruption of the blood-brain barrier. This activity is
Pleurocybella_porrigens
Enzyme involved in the synthesis of vitamin C
adaptation occurred after the loss of the GULO gene by primates. Erythrocyte Glut1 and associated dehydroascorbic acid uptake modulated by stomatin switch
L-gulonolactone_oxidase
Reduced oxygen-carrying ability of the blood due to breakdown of red blood cells
destroys red blood cells (though the mechanism of hemolysis is still unclear). GLUT1 deficiency syndrome 2 may sometimes cause Hemolytic anemia. Acquired hemolytic
Hemolytic_anemia
Class of drugs to lower cholesterol
production of certain proteins responsible for glucose uptake into cells such as GLUT1. Several meta-analyses have found no increased risk of cancer, and some
Statin
Tumor originating from blood or lymph vessels
van der Vleuten, CJM; Flucke, U; Blokx, WAM (June 2017). "The utility of GLUT1 as a diagnostic marker in cutaneous vascular anomalies: A review of literature
Vascular_tumor
Type of membrane transport proteins
cholestasis FOLT, SLC19A1, RFC1 Folate malabsorption/megaloblastic anemia GLUT1, SLC2A1 low CNS glucose causing seizures, Fanconi-Bickel syndrome, Glycogen
Cotransporter
Protein-coding gene in the species Homo sapiens
with a variety of other receptor and cytoskeletal proteins including the GLUT1 receptor, ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4, SEMA4C/semaphorin-4
GIPC1
Protein-coding gene in humans
"Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy". Am
SLC2A12
Supplement and medication used to treat sleep disorders
membrane include, but are not limited to, glucose transporters, including GLUT1, and the proton-driven oligopeptide transporters PEPT1 and PEPT2. Melatonin
Melatonin as a medication and supplement
Melatonin_as_a_medication_and_supplement
Protein-coding gene in the species Homo sapiens
analogous to the effect of mutation of the cerebral glucose transporter GLUT1(SLC2A1). GRCh38: Ensembl release 89: ENSG00000162426 – Ensembl, May 2017
SLC45A1
Type of cell found in pancreatic islets
whereas human beta cells, although also expressing GLUT2, mainly make use of GLUT1 and GLUT3 isoforms. Since beta cells use glucokinase to catalyze the first
Beta_cell
American biopharmaceutical company
Acid Cycle. Trials on this drug as treatment for a different condition, Glut1 deficiency, a seizure disorder, were halted in 2017 due to a failure of
Ultragenyx
Raised red skin lesion that affects infants caused by benign vascular tumor
S2CID 21550296. North PE, Waner M, Mizeracki A, Mihm MC Jr (Jan 2000). "GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas"
Infantile_hemangioma
High blood sugar levels during pregnancy
Because glucose travels across the placenta (through diffusion facilitated by GLUT1 carrier), which is located in the syncytiotrophoblast on both the microvilli
Gestational_diabetes
Species of virus
unit of the virion envelope glycoprotein (SU) with its cellular receptor GLUT1, a glucose transporter, on target cells. HTLV-1 is also associated with
Human_T-lymphotropic_virus_1
Human chromosome
disease Gaucher-like disease Gelatinous drop-like corneal dystrophy Glaucoma GLUT1 deficiency syndrome Hearing loss, autosomal recessive deafness 36 Hemochromatosis
Chromosome_1
Medical condition
and kidneys, also out of) the cell. De Vivo disease (GLUT1 deficiency) is a deficiency of GLUT1, which is needed to transport glucose across the blood-brain
Inborn errors of carbohydrate metabolism
Inborn_errors_of_carbohydrate_metabolism
Chemical compound
acknowledged. Trum M, Wagner S, Maier LS, Mustroph J (June 2020). "CaMKII and GLUT1 in heart failure and the role of gliflozins". Biochimica et Biophysica Acta
Ertugliflozin
Protein-coding gene in humans
increases chemoresistance. This happens due to the activation of the AKT-GLUT1/HK2 cascade (The AKT-glucose transporter 1-hexokinase2 pathway is responsible
CPNE1
mTORC1, it activates akt, which in turn promotes glucose transporter 1 (GLUT1) membrane deposition. It also further promotes, through other kinases, cell
Immunometabolism
Informal grouping of virus species
(Env) surface subunit (SU) binding to a cellular receptor (in this case GLUT1 and a host of other molecules), and ending with lysis of the cell (in this
Primate_T-lymphotropic_virus
Protein-coding gene in humans
cell signaling receptors like c-Raf and PI 3-kinase. KRAS upregulates the GLUT1 glucose transporter, thereby contributing to the Warburg effect in cancer
KRAS
Protein-coding gene in the species Homo sapiens
to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1". Cardiovascular Research. 59 (3): 639–48. doi:10.1016/S0008-6363(03)00472-3
FOSL2
Chinese structural biologist
mechanism of membrane transport protein, exemplified by the glucose transporter GLUT1 and voltage-gated sodium and calcium channels. In 2017, Yan decided to leave
Yan_Ning
Protein family
PiPT, plant nitrate transporter NRT1.1, and the human glucose transporter GLUT1. The origin of the basic MFS transporter fold is currently under heavy debate
Major_facilitator_superfamily
Mammalian protein found in Homo sapiens
Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton". Mol. Biol. Cell. 10 (4): 819–32. doi:10.1091/mbc
KIF1B
Medical diagnostic method
hemorrhage, hypoglycemia (low blood sugar), impaired glucose transport (e.g. GLUT1 deficiency syndrome), increased CNS glycolytic activity and metastatic carcinoma
CSF_glucose
Transmembrane carrier protein
(Primary) pancreatic β cell (Primary in mice, tertiary in humans after GLUT1 and GLUT3) hypothalamus (Not overly significant) basolateral membrane of
GLUT2
Protein-coding gene in the species Homo sapiens
glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton". Mol. Biol. Cell. 10 (4): 819–32. doi:10.1091/mbc
Alpha-actinin-1
Endogenous tag expressed in different cells along neurogenesis and differentiated cells
alpha/NR2B1; Frizzled-9; sFRP-2; GATA-2; SLAIN 1; GCNF/NR6A1; SOX1; GFAP; SOX2; Glut1; SOX9; HOXB1; SOX11; ID2; SOX21; Meteorin; SSEA-1; MSX1; TRAF-4; Musashi-1;
Neuronal_lineage_marker
fibronectin antibodies but not by GLUT1 antibodies. The subcommissural organ appears to be unique in that it shows neither GLUT1 nor capillary. Reissner's fiber
Subcommissural_organ
Protein-coding gene in the species Homo sapiens
articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9". Cell Biol. Int. 26 (3): 297–300. doi:10.1006/cbir.2001
SLC2A9
Protein-coding gene in mammals
kinase pathway. FGF21 injection in ob/ob mice results in an increase in Glut1 in adipose tissue. FGF21 also protects animals from diet-induced obesity
Fibroblast_growth_factor_21
Protein-coding gene in humans
metabolism and diabetes has been reported, including the involvement in GLUT1 and GLUT2 transporter expression in pancreatic β-cells and angiotensin-converting
HNF1A
American cell biologist, born 1941
clone and sequence mRNAs encoding a mammalian glucose transport protein, GLUT1, and then GLUT2 and the insulin- responsive GLUT4, an anion exchange protein
Harvey_Lodish
Mammalian protein found in Homo sapiens
Hayashi H, Ebina Y, et al. (1999). "Association of stomatin (band 7.2b) with Glut1 glucose transporter". Arch. Biochem. Biophys. 372 (1): 173–8. doi:10.1006/abbi
Stomatin
Chemical compound
usual substrates. Cytochalasin B has been shown to inhibit GLUT1, 2, 3 and 4. Binding to GLUT1 occurs at the inside as cytochalasin B acts as it acts as
Cytochalasin_B
Index of articles on biophysics
GABRP GABRQ GABRR1 GABRR2 GABRR3 GHK flux equation GLRA2 GLRA3 GLRA4 GLRB GLUT1 GLUT8 GPCR oligomer GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5
Index_of_biophysics_articles
Structures projecting from cells
that impedes the filtration of albumin. Astrocytic endfeet are rich in: GLUT1 transporters, responsible for the transport of glucose across the BBB into
Cellular_extensions
of TXNIP by the toxic glucose analog 2DG stimulates glucose transporter GLUT1 internalization in HepG2 cells. Thus, α-arrestins are critical for fundamental
Alpha_Arrestin
Protein-coding gene in the species Homo sapiens
induces ER stress by changing glycosylation and function of GLUT1". Arch. Biochem. Biophys. 463 (1): 102–9. doi:10.1016/j.abb.2007.03.005
MGAT5
Group of neurological genetic diseases involving misshapen spiky red blood cells
Levine-Critchley syndrome (see History). Paroxysmal movement disorders associated with GLUT1 mutations. Familial acanthocytosis with paroxysmal exertion-induced dyskinesias
Neuroacanthocytosis
Physiological phenomenon of transfer of stress to foetus during pregnancy
transmission (HSD11B2, NR3C1, NR3C2). The results showed that except for GLUT1, all other genes were higher in female than male placentas. During the pregnancy
Maternal fetal stress transfer
Maternal_fetal_stress_transfer
Gene on human chromosome 5
proliferation and glycolysis in hepatocellular carcinoma by regulating GLUT1". Cancer Biology & Therapy. 24 (1) 2225884. doi:10.1080/15384047.2023.2225884
BTF3
the Major Facilitator Super Family (MFS) and is homologue of the human GLUT1 transporter (4). Below you will find descriptions of the structure, specificity
GalP_(protein)
American medical researcher (born 1942)
(1997). "The rat corpulent (cp) mutation maps to the same interval on (Pgm1-Glut1) rat chromosome 5 as the fatty (fa) mutation". Obes Res. 5 (2): 142–5. doi:10
Rudolph_Leibel
Enzyme
the deamination of SSAO, acts as a signal-transducing molecule, affecting GLUT1 and GLUT4 translocation to the plasma membrane by granulosa cells and adipose
AOC3
Protein-coding gene in the species Homo sapiens
linked to aerobic glycolysis, as Skp2 deficiency impairs Akt activation, Glut1 expression, and glucose uptake thereby promoting cancer development. Skp2
SKP2
Protein-coding gene in the species Homo sapiens
phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 5-phosphate. GLUT1 5 is a protein that is recycled via the process of endosome-to-plasma membrane
WASHC2C
MC2R Glucose-galactose malabsorption; 606824; SLC5A1 GLUT1 deficiency syndrome 1; 606777; SLC2A1 GLUT1 deficiency syndrome 2; 612126; SLC2A1 Glutamate formiminotransferase
List_of_OMIM_disorder_codes
GLUT1
GLUT1
GLUT1
GLUT1
Surname or Lastname
English
English : patronymic from Huling.
Boy/Male
Indian, Punjabi, Sikh
Brave and Knowledgeable
Girl/Female
Assamese, Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Telugu
Knowledge of Truth
Girl/Female
Hindu
Endless
Girl/Female
Tamil
Nemishta | நேமீஷதாÂ
Sweet, Satisfies
Girl/Female
Tamil
Shraviya | à®·à¯à®°à®µà®¿à®¯à®¾
Enthusiastic, Talented person, Like to live with good characters, They dont fear for anything, Successive person & angry when irritated
Boy/Male
Indian, Sanskrit
Guide
Girl/Female
Muslim
A pious woman
Boy/Male
French German
Guards; guardian.
Boy/Male
Buddhist, Hindu, Indian, Sanskrit
Conquering; Without Grief
GLUT1
GLUT1
GLUT1
GLUT1
GLUT1