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Atypical antidepressant drug
Nefazodone, sold formerly under the brand names Serzone, Dutonin, and Nefadar among others, is an atypical antidepressant medication which is used in the
Nefazodone
Chemical compound
antidepressant nefazodone. It has similar biological activity and a similar elimination half-life (1.5 to 4 hours) to those of nefazodone, and may contribute
Hydroxynefazodone
Dextromethorphan/bupropion (Auvelity) Toludesvenlafaxine (Ruoxinlin) Nefazodone (Serzone) Serotonin modulators and stimulators include: Vilazodone (Viibryd)
List_of_antidepressants
Phenylpiperazine compound
metabolite of the antidepressant nefazodone. It is active, but with substantially reduced potency compared to nefazodone (approximately one-seventh). As
Triazoledione
Medical condition
rasagiline), serotonin antagonists and reuptake inhibitors (SARIs) (e.g., nefazodone), psychostimulants (e.g., methylphenidate, dextroamphetamine), typical
Spontaneous_orgasm
Class of chemical compounds
(TFMPP) 1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine (3C-PEP) Trazodone, nefazodone, etoperidone, mepiprazole, and others produce mCPP as a metabolite.
Substituted_piperazine
Class of antidepressant medication
opipramol tianeptine maprotiline mianserin mirtazapine Topiramate trazodone nefazodone The agents vilazodone and vortioxetine are partly atypical. Typical antidepressants
Atypical_antidepressant
SSRI antidepressant
sertraline is similar in efficacy against depression to moclobemide, nefazodone, escitalopram, bupropion, citalopram, fluvoxamine, paroxetine, venlafaxine
Sertraline
Class of drug
(Normarex),[citation needed] mepiprazole (Psigodal),[citation needed] nefazodone, utility complicated by life-threatening idiosyncratic hepatotoxicity
Serotonin antagonist and reuptake inhibitor
Serotonin_antagonist_and_reuptake_inhibitor
Chemical compound
was never marketed. It is a phenylpiperazine related to trazodone and nefazodone in chemical structure and is a serotonin antagonist and reuptake inhibitor
Etoperidone
Triazolobenzodiazepine sleep medication
cimetidine, diltiazem, fluconazole, grapefruit juice, isoniazid, itraconazole, nefazodone, rifampicin, ritonavir, and troleandomycin. Triazolam should not be administered
Triazolam
Psychedelic drug
Phentolamine Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione) Piperoxan Prazosin Quinazosin Quinidine Silodosin
LSD
SSRI antidepressant
SARIsTooltip Serotonin antagonist and reuptake inhibitors Etoperidone Nefazodone Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine
Fluoxetine
Dissociative anesthetic and anti-depressant
Thiethylperazine Trazpiroben Trimethobenzamide Antidepressants: Amoxapine Nefazodone Opipramol Propiomazine Trimipramine Others: 3-PPP 5-Hydroxyindoline ABT-925
Ketamine
Central nervous system stimulant
Piperazines: DBL-583 GBR-12783 GBR-12935 GBR-13069 GBR-13098 JJC8-088 Nefazodone Vanoxerine Piperidines: 4-Fluoropethidine Benocyclidine (BTCP) Desoxypipradrol
Methylphenidate
Chemical compound
antagonist and reuptake inhibitor (SARI) in the same group as trazodone, nefazodone, and etoperidone. Acaprazine Enpiprazole Mepiprazole Tolpiprazole Elks
Lorpiprazole
Class of antidepressant medication
Archived from the original (PDF) on 26 June 2016. Retrieved 29 August 2016. "Nefazodone hydrochloride tablet". DailyMed. 16 November 2021. Retrieved 12 February
Serotonin–norepinephrine reuptake inhibitor
Serotonin–norepinephrine_reuptake_inhibitor
Benzodiazepine medication
erythromycin, norfluoxetine, fluvoxamine, itraconazole, ketoconazole, nefazodone, propoxyphene, and ritonavir delay the hepatic clearance of alprazolam
Alprazolam
Visual disorder in which images persist after removal of their stimuli
HPPD, prescription drugs, head trauma, or may be idiopathic. Trazodone, nefazodone, mirtazapine, topiramate, clomiphene, oral contraceptives, and risperidone
Palinopsia
Antidepressant medication
triazolopyridine derivative and a phenylpiperazine that is structurally related to nefazodone and etoperidone, each of which is a derivative of it. Trazodone was developed
Trazodone
Class of antidepressant medication
switching to bupropion; and for overall sexual dysfunction, switching to nefazodone. Buspirone is sometimes used off-label to reduce sexual dysfunction associated
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Psychoactive substance found in plants in the family Apocynaceae
Piperazines: DBL-583 GBR-12783 GBR-12935 GBR-13069 GBR-13098 JJC8-088 Nefazodone Vanoxerine Piperidines: 4-Fluoropethidine Benocyclidine (BTCP) Desoxypipradrol
Ibogaine
Psychoactive drug, often called ecstasy
Adatanserin Amphetamine Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics
MDMA
Benzodiazepine medication
Erythromycin, clarithromycin, ritonavir, itraconazole, ketoconazole, nefazodone, cimetidine, and grapefruit juice are inhibitors of CYP3A4 and can affect
Clonazepam
Benzodiazepine used for anesthesia and procedural sedation
and the appearance of adverse depressant effects. Protease inhibitors, nefazodone, sertraline, grapefruit, fluoxetine, erythromycin, diltiazem, and clarithromycin
Midazolam
Drug that reduces excitement without inducing sleep
Desipramine (Norpramin) Doxepin Imipramine (Tofranil) Mirtazapine (Remeron) Nefazodone Nortriptyline (Pamelor) Trazodone (Desyrel) Trimipramine (Surmontil) Antipsychotics
Sedative
Amphetamine Salts, Moclobemide, Modafinil Nalmefene, Naltrexone, Necopidem, Nefazodone, Nitrazepam, Nortriptyline Ocinaplon, Olanzapine, Opipramol, Oxazepam
List of psychiatric medications
List_of_psychiatric_medications
SSRI antidepressant
SARIsTooltip Serotonin antagonist and reuptake inhibitors Etoperidone Nefazodone Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine
Citalopram
Erectile female sexual organ
which case discontinuing the medication may be a remedy. Additionally, nefazodone is documented to have caused clitoral engorgement, as distinct from clitoral
Clitoris
Tetrahydropalmatine • Tiapride • UH-232 • Yohimbine Piperazines: DBL-583 • GBR-12,935 • Nefazodone • Vanoxerine Piperidines: 1-(1-(1-Benzothiophen-2-yl)cyclohexyl)piperidine
List_of_dopaminergic_drugs
Medication used to treat anxiety disorders
plasma level of buspirone Rifampicin: Decreased plasma levels of buspirone Nefazodone: Increased plasma levels of buspirone Haloperidol: Increased plasma levels
Buspirone
Pharmacodynamics and pharmacokinetics of ethanol
Adatanserin Amphetamine Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics
Pharmacology_of_ethanol
Symptoms caused by an excess of serotonin in the central nervous system
85% of the general practitioners that had prescribed the antidepressant nefazodone were unaware of serotonin syndrome. The incidence may be increasing as
Serotonin_syndrome
Muscle relaxant medication
Phentolamine Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione) Piperoxan Prazosin Quinazosin Quinidine Silodosin
Cyclobenzaprine
Serotonergic drug
metabolite of a variety of other piperazine drugs including trazodone, nefazodone, etoperidone, mepiprazole, cloperidone, peraclopone, and BRL-15,572.[additional
Meta-Chlorophenylpiperazine
Class of antidepressants
(Zoloft), as well as some non-SSRI antidepressants such as mirtazapine, nefazodone, venlafaxine, duloxetine and reboxetine. However, this usage is not universal
Second-generation antidepressant
Second-generation_antidepressant
SSRI antidepressant
SARIsTooltip Serotonin antagonist and reuptake inhibitors Etoperidone Nefazodone Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine
Escitalopram
Medication to prevent nausea and vomiting
Adatanserin Amphetamine Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics
Ondansetron
Synthetic opioid pain medication
Piperazines: DBL-583 GBR-12783 GBR-12935 GBR-13069 GBR-13098 JJC8-088 Nefazodone Vanoxerine Piperidines: 4-Fluoropethidine Benocyclidine (BTCP) Desoxypipradrol
Tramadol
Antidepressant medication
SARIsTooltip Serotonin antagonist and reuptake inhibitors Etoperidone Nefazodone Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine
Mirtazapine
Medication to treat gastroesophageal reflux disease and other conditions
(prasterone) Efavirenz Ellagic acid Griseofulvin Methoxychlor Mifepristone Nefazodone Nevirapine Nicardipine Octicizer Permethrin Phenobarbital Phenytoin Pregnanedione
Omeprazole
Medication used to treat premature ejaculation
Piperazines: DBL-583 GBR-12783 GBR-12935 GBR-13069 GBR-13098 JJC8-088 Nefazodone Vanoxerine Piperidines: 4-Fluoropethidine Benocyclidine (BTCP) Desoxypipradrol
Dapoxetine
Neurotransmission-modulating substance
and Alpha 1 (a1) adrenoreceptors. Risperidone antipsychotic Trazodone Nefazodone Another subclass consists of drugs selectively acting at the 5-HT3 receptors
Serotonin_receptor_antagonist
Benzodiazepine sedative
metabolism of diazepam. Diazepam increases the serum levels of phenobarbital. Nefazodone can cause increased blood levels of benzodiazepines. Cisapride may enhance
Diazepam
Obsolete sedative–hypnotic drug
Antidepressants Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine
Methaqualone
Class of medication used to treat depression and other conditions
averaged 59.1% with SSRI values between 57% and 73%, mirtazapine 24%, nefazodone 8%, amineptine 7%, and moclobemide 4%. Moclobemide, a selective reversible
Antidepressant
Antihistamine medication
zotepine) Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione) Tetracyclic antidepressants (e.g., amoxapine
Cetirizine
Chemical compound
zotepine) Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione) Tetracyclic antidepressants (e.g., amoxapine
Meclizine
Pharmaceutical compound
Piperazines: DBL-583 GBR-12783 GBR-12935 GBR-13069 GBR-13098 JJC8-088 Nefazodone Vanoxerine Piperidines: 4-Fluoropethidine Benocyclidine (BTCP) Desoxypipradrol
Cendifensine
Dopamine agonist medication
Thiethylperazine Trazpiroben Trimethobenzamide Antidepressants: Amoxapine Nefazodone Opipramol Propiomazine Trimipramine Others: 3-PPP 5-Hydroxyindoline ABT-925
Pramipexole
Atypical antipsychotic medication
3-dichlorophenylpiperazines and is chemically related to cariprazine, nefazodone, etoperidone, and trazodone. It is unusual in having twelve known crystalline
Aripiprazole
Tropane alkaloid and stimulant drug
Piperazines: DBL-583 GBR-12783 GBR-12935 GBR-13069 GBR-13098 JJC8-088 Nefazodone Vanoxerine Piperidines: 4-Fluoropethidine Benocyclidine (BTCP) Desoxypipradrol
Cocaine
Drug for angina pectoris sold under many brand names
Levodropropizine Lorpiprazole mCPP Mefway MeOPP Mepiprazole Naftopidil Naluzotan Nefazodone Niaprazine Oxypertine Pardoprunox pCPP pFPP Posaconazole S-14,506 S-14
Trimetazidine
SSRI antidepressant
SARIsTooltip Serotonin antagonist and reuptake inhibitors Etoperidone Nefazodone Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine
Fluvoxamine
Medication mainly used for depression and smoking cessation
SARIsTooltip Serotonin antagonist and reuptake inhibitors Etoperidone Nefazodone Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine
Bupropion
Psychological disorder of morality
Escitalopram Fluoxetine Fluvoxamine Paroxetine Sertraline Citalopram Nefazodone Monoamine oxidase inhibitors Phenelzine Tricyclic antidepressants Clomipramine
Scrupulosity
Atypical antipsychotic medication
Phentolamine Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione) Piperoxan Prazosin Quinazosin Quinidine Silodosin
Quetiapine
Wakefulness-promoting medication
Piperazines: DBL-583 GBR-12783 GBR-12935 GBR-13069 GBR-13098 JJC8-088 Nefazodone Vanoxerine Piperidines: 4-Fluoropethidine Benocyclidine (BTCP) Desoxypipradrol
Modafinil
Chemical compound
Phentolamine Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione) Piperoxan Prazosin Quinazosin Quinidine Silodosin
Apomorphine
Brazil's federal drug control statute
authorization only. Moclobemide Molnupiravir Moperone Naloxone Naltrexone Nefazodone Nialamide Isobutyl nitrite Isopentyl nitrite Isopropyl nitrite Nomifensine
Brazilian Controlled Drugs and Substances Act
Brazilian_Controlled_Drugs_and_Substances_Act
Antihistamine medication
zotepine) Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione) Tetracyclic antidepressants (e.g., amoxapine
Loratadine
Hypnotic medication
Ketoconazole and sulfaphenazole interfere with the metabolism of zopiclone. Nefazodone impairs the metabolism of zopiclone leading to increased zopiclone levels
Zopiclone
Intravenous medication used in anesthesia
Antidepressants Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine
Propofol
Medical usage of the prasterone compound
(prasterone) Efavirenz Ellagic acid Griseofulvin Methoxychlor Mifepristone Nefazodone Nevirapine Nicardipine Octicizer Permethrin Phenobarbital Phenytoin Pregnanedione
Prasterone
Cough suppressant and dissociative drug
Piperazines: DBL-583 GBR-12783 GBR-12935 GBR-13069 GBR-13098 JJC8-088 Nefazodone Vanoxerine Piperidines: 4-Fluoropethidine Benocyclidine (BTCP) Desoxypipradrol
Dextromethorphan
Personality disorder involving extreme asociality
Not general practice but may include low dose benzodiazepines, β-blockers, nefazodone, bupropion Prognosis Typically poor Frequency 0.9–1.3% (median)
Schizoid_personality_disorder
Class of drugs
having completed phase II trials in May 2025. Despite being a weak SNDRI, nefazodone has been successful in treating major depressive disorder. Centanafadine
Serotonin–norepinephrine–dopamine reuptake inhibitor
Serotonin–norepinephrine–dopamine_reuptake_inhibitor
Opioid medication
(prasterone) Efavirenz Ellagic acid Griseofulvin Methoxychlor Mifepristone Nefazodone Nevirapine Nicardipine Octicizer Permethrin Phenobarbital Phenytoin Pregnanedione
Fentanyl
SNRI antidepressant
SARIsTooltip Serotonin antagonist and reuptake inhibitors Etoperidone Nefazodone Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine
Desvenlafaxine
Psychological or sexual drive or energy
with the exception of bupropion (Wellbutrin), trazodone (Desyrel) and nefazodone (Serzone), antidepressants generally will lead to lowered libido. SSRIs
Libido
Pharmaceutical compound
Adatanserin Amphetamine Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics
1F-LSD
Pathological fear of contamination and germs
Escitalopram Fluoxetine Fluvoxamine Paroxetine Sertraline Citalopram Nefazodone Monoamine oxidase inhibitors Phenelzine Tricyclic antidepressants Clomipramine
Mysophobia
Pharmaceutical compound
Adatanserin Amphetamine Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics
Nuciferine
Barbiturate
Antidepressants Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine
Amobarbital
Chemical stimulant produced by some plants
(prasterone) Efavirenz Ellagic acid Griseofulvin Methoxychlor Mifepristone Nefazodone Nevirapine Nicardipine Octicizer Permethrin Phenobarbital Phenytoin Pregnanedione
Nicotine
Opioid analgesic of benzenoid class
Piperazines: DBL-583 GBR-12783 GBR-12935 GBR-13069 GBR-13098 JJC8-088 Nefazodone Vanoxerine Piperidines: 4-Fluoropethidine Benocyclidine (BTCP) Desoxypipradrol
Tapentadol
Medication used for cancer
(prasterone) Efavirenz Ellagic acid Griseofulvin Methoxychlor Mifepristone Nefazodone Nevirapine Nicardipine Octicizer Permethrin Phenobarbital Phenytoin Pregnanedione
Paclitaxel
Pharmaceutical compound
Adatanserin Amphetamine Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics
ASR-3001
Antidepressants Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine
Bromoureide
Pharmaceutical compound
Adatanserin Amphetamine Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics
Tryptoline
Pharmaceutical compound
Antidepressants Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine
Mephenaqualone
Class of drug
clinically-relevant: adrafinil, armodafinil, bupropion, mazindol, modafinil, nefazodone, sertraline, and sibutramine. The following drugs are or have been clinically
Dopamine_reuptake_inhibitor
Pharmaceutical compound
zotepine) Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione) Tetracyclic antidepressants (e.g., amoxapine
Diphenhydramine/lorazepam/zolpidem
Diphenhydramine/lorazepam/zolpidem
Psychoactive component of cannabis
(prasterone) Efavirenz Ellagic acid Griseofulvin Methoxychlor Mifepristone Nefazodone Nevirapine Nicardipine Octicizer Permethrin Phenobarbital Phenytoin Pregnanedione
Tetrahydrocannabinol
Group of four possible stereoisomers found in various plants: a.o., absinthe and mint
Adatanserin Amphetamine Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics
Thujone
Pharmaceutical compound
Thiethylperazine Trazpiroben Trimethobenzamide Antidepressants: Amoxapine Nefazodone Opipramol Propiomazine Trimipramine Others: 3-PPP 5-Hydroxyindoline ABT-925
ASP-4345
Antidepressant compound
SARIsTooltip Serotonin antagonist and reuptake inhibitors Etoperidone Nefazodone Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine
Nitrafudam
Chemical compound
zotepine) Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione) Tetracyclic antidepressants (e.g., amoxapine
Betahistine
Medication used to treat insomnia
clarithromycin, conivaptan, indinavir, itraconazole, ketoconazole, lopinavir, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, and telithromycin
Daridorexant
Group of chemical compounds
Adatanserin Amphetamine Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics
Β-Carboline
Class of CNS depressant drugs
Antidepressants Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine
Benzodiazepine
Pharmaceutical compound
Antidepressants Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine
Pellotine
SNRI medication
SARIsTooltip Serotonin antagonist and reuptake inhibitors Etoperidone Nefazodone Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine
Duloxetine
Antidepressant medication
SARIsTooltip Serotonin antagonist and reuptake inhibitors Etoperidone Nefazodone Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine
Vilazodone
Chemical compound
Adatanserin Amphetamine Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics
Naratriptan
Pharmaceutical compound
Adatanserin Amphetamine Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics
UCSF648
Compounds metabolized into monoamines
Phentolamine Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione) Piperoxan Prazosin Quinazosin Quinidine Silodosin
Monoamine_precursor
Drug class
mianserin, mirtazapine, and esmirtazapine; SARIs and related like trazodone, nefazodone, mepiprazole, niaprazine, and lubazodone; and others like adatanserin
Serotonin 5-HT2A receptor antagonist
Serotonin_5-HT2A_receptor_antagonist
South American psychoactive decoction
Adatanserin Amphetamine Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine) AP-521 Atypical antipsychotics
Ayahuasca
Chemical compound
Piperazines: DBL-583 GBR-12783 GBR-12935 GBR-13069 GBR-13098 JJC8-088 Nefazodone Vanoxerine Piperidines: 4-Fluoropethidine Benocyclidine (BTCP) Desoxypipradrol
NS-2359
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NEFAZODONE
NEFAZODONE
NEFAZODONE
NEFAZODONE
NEFAZODONE
NEFAZODONE
NEFAZODONE
NEFAZODONE
NEFAZODONE
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