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Family of cell adhesion molecules
The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs). All selectins are single-chain transmembrane glycoproteins
Selectin
Type-1 transmembrane protein
P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. P-selectin functions as a cell adhesion molecule (CAM) on the
P-selectin
Mammalian protein found in humans
L-selectin, also known as CD62L, is a cell adhesion molecule found on the cell surface of leukocytes, and the blastocyst. It is coded for in humans by
L-selectin
Protein-coding gene in the species Homo sapiens
Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene. SELPLG codes for PSGL-1, the high affinity counter-receptor
P-selectin glycoprotein ligand-1
P-selectin_glycoprotein_ligand-1
Mammalian protein found in humans
E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell
E-selectin
Movement of white blood cells out of blood vessels and towards the inflamed site
presenting pre-formed P-selectins on the endothelial cell surface. P-selectins bind PSGL-1 as a ligand. E-selectins: E-selectin is expressed on activated
Leukocyte_extravasation
Multiprotein complex that forms a point of contact or adhesion in animal cells
selectin is limited to leukocyte collaborations with vascular endothelium. There are three types of selectins found in humans; L-selectin, P-selectin
Cell_junction
This is a list of astronauts by year of selection: people selected to train for a human spaceflight program to command, pilot, or serve as a crew member
List of astronauts by year of selection
List_of_astronauts_by_year_of_selection
Chemical compound
that are present on the cell surface. The sialyl-LewisX determinant, E-selectin ligand carbohydrate structure, is constitutively expressed on granulocytes
Sialyl-Lewis_X
Cell-surface glycoprotein
sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). (see below) Transcripts
CD44
adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin). The cellular expression of CAMs
Soluble cell adhesion molecules
Soluble_cell_adhesion_molecules
Type of chemical bond
has indeed been observed for interactions of P-selectin with PSGL-1 or anti-P-selectin antibody, L-selectin with PSGL-1, myosin with actin, integrin alpha
Catch_bond
Class of compounds
function. Sulfatide also acts as an L-selectin and P-selectin ligand, but it does not act as an E- selectin ligand. Selectins are adhesion molecules that facilitate
Sulfatide
Biochemistry concept
sialo fucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination
Carcinoembryonic_antigen
Subset of cell adhesion proteins
are E-selectin (endothelial), L-selectin (leukocyte), and P-selectin (platelet). The best-characterized ligand for the three selectins is P-selectin glycoprotein
Cell_adhesion_molecule
for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues. GLYCAM1 binds to L-selectin by presenting one
GLYCAM1
Monoclonal antibody
Adakveo among others, is a monoclonal antibody medication that binds to P-selectin. It is a medication used to reduce the frequency of vaso-occlusive crisis
Crizanlizumab
process by interacting with L-selectin, which is present on the surface of lymphocytes. The adhesion molecule L-selectin binds to sulfated carbohydrate
Peripheral_node_addressin
Physical effects resulting from activation of the immune system
Inflammatory cytokines induce the immediate expression of P-selectin on endothelial cell surfaces and P-selectin binds weakly to carbohydrate ligands on the surface
Inflammation
Protein-coding gene in the species Homo sapiens
protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012]. Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes
PODXL2
Storage granules of endothelial cells
store and release two principal molecules, von Willebrand factor and P-selectin, and thus play a dual role in hemostasis and inflammation. Weibel–Palade
Weibel–Palade_body
First stage of pregnancy
carbohydrate moieties on its extracellular domain that are ligands of L-selectin, a cell adhesion molecule on the surface of trophoblast cells. An in vitro
Implantation_(embryology)
Venules in some lymphatic organs
addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor them to the HEV wall in preparation for crossing
High_endothelial_venules
Danish healthcare company
Amivantamab " " Advanced or metastatic colorectal cancer I/II " Inclacumab selectin P Pfizer VOC in Sickle cell disease III Est. prim. completion 2023-12 5-6%
Genmab
Class of drugs to lower cholesterol
Pravastatin Aplactin, Lipostat, Prasterol, Pravachol, Pravaselect, Sanaprav, Selectin, Selektine, Vasticor Fermentation-derived (a fermentation product of bacterium
Statin
Formation of a blood clot in a deep vein
patients who are acutely or critically ill. Inhibition of factor XI, P-selectin, E-selectin, and a reduction in formation of neutrophil extracellular traps are
Deep_vein_thrombosis
Medical condition
attributable to the absence of neutrophil sialyl-LewisX, a ligand of P- and E-selectin on vascular endothelium. It is associated with SLC35C1. This disorder was
Congenital disorder of glycosylation type IIc
Congenital_disorder_of_glycosylation_type_IIc
the selectin family, mucin-like family, and the Ig superfamily. Naive lymphocyte extravasation into Peyer’s patches is often mediated by L-selectin and
Lymphocyte_homing_receptor
Medical condition
four classes of selectin blocking agents: (i) carbohydrate-based inhibitors targeting all P-, E-, and L-selectins, (ii) antihuman selectin antibodies, (iii)
Allergic_conjunctivitis
Subset of T lymphocytes
(TCM cells) express CD45RO, C-C chemokine receptor type 7 (CCR7), and L-selectin (CD62L). Central memory T cells also have intermediate to high expression
Memory_T_cell
Component of blood aiding in coagulation
injury. Granule characteristics: α granules (alpha granules) — containing P-selectin, platelet factor 4, transforming growth factor-β1, platelet-derived growth
Platelet
Process of cell attachment
and selectins. Cadherins and IgSF are homophilic CAMs, as they directly bind to the same type of CAMs on another cell, while integrins and selectins are
Cell_adhesion
Membrane receptor
bind to a number of other ligands in the circulation such as thrombin, P-selectin, factor XI, factor XII, high molecular weight kininogen as well as bacteria
Glycoprotein_Ib-IX-V_complex
Mammalian hormone released from the pituitary gland
Davenpeck KL, et al. (October 1995). "Desmopressin induces endothelial P-selectin expression and leukocyte rolling in postcapillary venules". Blood. 86 (7):
Vasopressin
Cellular component of platelets
Willebrand factor). The alpha granules express the adhesion molecule P-selectin and CD63. These are transferred to the membrane after synthesis. The other
Alpha_granule
Medical condition
microvesicles. Some adenocarcinomas secrete mucin that can interact with selectin found on platelets, thereby causing small clots to form. Moreover, most
Trousseau_sign_of_malignancy
Branch of medicine studying the immune system
opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion
Immunology
Protein found in humans
enter lymph nodes. It is expressed on lymph node endothelia, whereas the L-selectin to which it binds is on the T cell. Conversely, under other circumstances
CD34
Cascade of intracellular and molecular events for transmission/amplification of signals
YAP1. Calcium-dependent cell adhesion molecules such as cadherins and selectins can also mediate mechanotransduction. Specialised forms of mechanotransduction
Signal_transduction
Unspecialized biological cell that can become specialized
Wojciechowski JC, Charles N, Liesveld JL, King MR (January 2008). "P-Selectin coated microtube for enrichment of CD34+ hematopoietic stem and progenitor
Stem_cell
Protein found in humans
preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into
Addressin
American chemist
Bloomington Stanford University Thesis Synthesis of carbohydrate-based ligands for the selectins and galectins (1997) Doctoral advisor Laura L. Kiessling
Nicola_Pohl
American biochemist
of results of a Phase II trial evaluating the use of SelG1, an anti-P-selectin antibody, in the reduction of vaso-occlusive pain crises in patients with
Richard_D._Cummings
Biomarkers of blood signals
hemostasis) include platelet factor 4 (PF4), β-thromboglobulin (β-TG), and P-selectin. Lippi G, Cervellin G, Franchini M, Favaloro EJ (November 2010). "Biochemical
Coagulation_activation_marker
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also plays
Proteasome
Layer of cells that line the inner surface of blood vessels
activated, which is characterized by the expression of molecules such as E-selectin, VCAM-1 and ICAM-1, which stimulate the adhesion of immune cells. Additionally
Endothelium
Protein domain
"ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding". Blood. 108 (7): 2275–9. doi:10.1182/blood-2006-02-005827. PMC 1895557
ADAM_(protein)
Protein-coding gene in humans
resides primarily across lysosomal membranes, and functions to provide selectins with carbohydrate ligands. CD107a has also been shown to be a marker of
LAMP1
Monoclonal antibody
Wright RS, L L'Allier P, Tardif JC (November 2016). "Effects of the P-Selectin Antagonist Inclacumab on Myocardial Damage After Percutaneous Coronary
Inclacumab
Group of signal transduction pathways involved in embryonic development
Dact1. Meanwhile Wnt is activated during the early outgrowth phase by E-selectin. The link between PGE2 and Wnt suggests that a chronic inflammation-related
Wnt_signaling_pathway
Human glycoprotein
pro-inflammatory cytokines, inducible nitric oxide synthase, tissue factor, P-selectin, intercellular adhesion molecule-1, phosphorylation of the extracellular
Ulinastatin
Type of white blood cell
(TCM cells) express CD45RO, C-C chemokine receptor type 7 (CCR7), and L-selectin (CD62L). Central memory T cells also have intermediate to high expression
T_cell
Medical condition
pain control. In 2019, crizanlizumab, a monoclonal antibody targeting P-selectin, was approved in the United States to reduce the frequency of vaso-occlusive
Sickle_cell_disease
Formation of blood cellular components
Weissleder, R; Magnani, JL; Swirski, FK; Nahrendorf, M (September 2016). "E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic
Haematopoiesis
Transmembrane receptors involved in cellular adhesion and signalling
as cadherins, the immunoglobulin superfamily cell adhesion molecules, selectins and syndecans, to mediate cell–cell and cell–matrix interaction. Ligands
Integrin
human activin receptor-like kinase 1 cancer Aselizumab mab humanized L-selectin (CD62L) severely injured patients Atezolizumab Tecentriq mab humanized
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Cuban-American vascular surgeon
States. Her work with University of Miamicolleague Zhao-Jun Liu showed E-selectin to be an important factor in promoting angiogenesis and healing, as well
Omaida_C._Velazquez
Medication
CYP3A4). Cimetidine is used in cancer metastasis research as a blocker of E-selectin. Cimetidine may significantly increase the blood levels of loperamide,
Cimetidine
Fat-laden M2 macrophages seen in atherosclerosis
blood vessel walls. Recruitment is facilitated by the molecules P-selectin and E-selectin, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion
Foam_cell
Polymer-based, crosslinked hydrogel particle
nanogels have been functionalized with fucoidan to target overexpressed P-selectin receptors on platelets and endothelial cells. After loading with miRNA
Nanogel
Mammalian protein involved in blood clotting
specific functions: The D'/D3 domain: Binds to factor VIII, heparin, and P-selectin. The A1 domain: Binds to the platelet GPIb-receptor, collagen types IV
Von_Willebrand_factor
Widening of blood vessels
represents velocity. Immune effector cells can more easily attach to selectins expressed on endothelial cells when blood is flowing slowly, enabling
Vasodilation
Type of adipose tissue
metabolic indicators, and with lower levels of C-reactive protein and E-selectin. Cold exposure increases circulating irisin. Irisin improves insulin sensitivity
Brown_adipose_tissue
Protein-coding gene in humans
Function in the Reconstitution of High Endothelial Cell Ligands for L-selectin". J Cell Biol. 145 (4): 899–910. doi:10.1083/jcb.145.4.899. PMC 2133194
CHST4
Mammalian protein found in humans
BG, Hieshima K, Fukuda M, Kannagi R, et al. (December 2004). "Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine
C-C_motif_chemokine_ligand_27
Protein-coding gene in the species Homo sapiens
Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis". Cancer Research. 65 (14): 6220–7. doi:10
B4GALNT2
Israeli cancer researcher
P., Friedmann-Morvinski, D., Madi, A., & Satchi-Fainaro, R. (2021). P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression
Ronit_Satchi-Fainaro
T cell which has not yet encountered its cognate antigen
Naive T cells are commonly characterized by the surface expression of L-selectin (CD62L) and C-C Chemokine receptor type 7 (CCR7); the absence of the activation
Naive_T_cell
Protein domain
between different selectin types. For example, EGF-like domains appear essential to ligand binding by P-selectin but not L-selectin, and are thus essential
EGF-like_domain
Mammalian protein found in Homo sapiens
syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands". Current Opinion in Hematology. 9 (1): 30–5. doi:10
Integrin_beta_2
Saccharide polymer
cells can express certain selectins transiently in response to damage or injury to the cells. In response, a reciprocal selectin–oligosaccharide interaction
Oligosaccharide
Human sialoglycoprotein
glycoforms of podocalyxin expressed by colon carcinoma cells possess L-selectin and E-selectin binding activity, and the affinity of the binding may be pivotal
Podocalyxin
Biological ability of cells to distinguish between types of neighboring cells
the site of an injury. A common example of this is selectin-expressing cells in animals. Selectin is a receptor protein found on the membranes of leukocytes
Cell–cell_recognition
Blood clot (thrombus) that forms within a vein
pathways lead to monocyte association with endothelial proteins, such as P-selectin, prompting monocytes to release tissue factor-filled microvesicles, which
Venous_thrombosis
Addition of a sulfate group to a tyrosine group in a protein
three tyrosines found in human PSGL-1 not only enhance its binding to P-selectin but also enables its pH-selective binding to the immune checkpoint protein
Tyrosine_sulfation
the cutaneous lymphocyte antigen (CLA) molecule, a modified form of P-selectin glycoprotein ligand-1. Lymphocytes move to the epidermis where they reside
Skin_immunity
British academic
"Levels of Soluble Platelet Endothelial Cell Adhesion Molecule-1 and P-Selectin Are Decreased in Children with Autism Spectrum Disorder". Biological Psychiatry
Paul_Ashwood
Medical condition
activation-regulated chemokine)/CCL17 (CC chemokine ligand 17) and/or E-selectin may interact with the cutaneous leucocyte-associated antigen (CLA) receptor
Leukemia_cutis
Type of immune cell
effector memory T cells lack the C-C chemokine receptor type 7 (CCR7) and L-selectin (CD62L) receptors, which prevents them from trafficking to the lymph nodes
T_helper_cell
Protein-coding gene in the species Homo sapiens
displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity". Int. Arch. Allergy Immunol. 126 (1): 78–90. doi:10.1159/000049497
OSGEP
Protein receptor active in neurons
(August 2016). "Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1 macrophages". Glia. 64
Neuropilin
Medical imaging technique
efficiencies, partly due to a dual-ligand selectin-integrin cell arrest system. One ligand:receptor pair (PSGL-1:selectin) has a fast bond on-rate to slow the
Contrast-enhanced_ultrasound
Biological process in animal connective tissue
Activated platelets have the ability to bind glycoproteins and glycolipids (P-selectin ligands such as PSGL-1) on the surface of cancer cells to form a physical
Epithelial–mesenchymal transition
Epithelial–mesenchymal_transition
Overview of and topical guide to immunology
(CD352) SLAMF7 (CD319) SLAMF8 (CD353) SLAMF9 Cadherins Selectins E-selectin L-selectin P-selectin Others Lymphocyte homing receptors CD34 GLYCAM-1 Addressin
Outline_of_immunology
Topics referred to by the same term
(disambiguation) Ilam (disambiguation) Eelam, Tamil name for Sri Lanka E-selectin, also known as endothelial-leukocyte adhesion molecule 1 (ELAM-1) This
Elam_(disambiguation)
Protein-coding gene in the species Homo sapiens
interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. SNX17 has been shown to interact with
SNX17
Biochemical classification for carbohydrates
antigen determination. SLex is also important to proper immune response. P-selectin release from Weibel-Palade bodies, on blood vessel endothelial cells, can
Glycoconjugate
Mammalian protein found in Homo sapiens
3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells". The Biochemical Journal. 360 (Pt 2): 363–370. doi:10
HMG-CoA_reductase
Post vaccination adverse effects
"Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance". Blood. 109 (7): 2832–2839
Embolic and thrombotic events after COVID-19 vaccination
Embolic_and_thrombotic_events_after_COVID-19_vaccination
Type of white blood cell
(position themselves adjacent to the blood vessel endothelium) and undergo selectin-dependent capture followed by integrin-dependent adhesion in most cases
Neutrophil
Maternal lymphocytes that make up 70% of the total found during pregnancy
immunoglobulin-like receptors. Notably, mouse models suggest that they lack CD16 and L-selectin, proteins that are prominent on pNKs (peripheral NK cells).[clarification
Uterine_natural_killer_cells
Form of immunotherapy
761297 crizanlizumab Adakveo Novartis 11/15/2019 intravenous humanized P selectin sickle-cell disease 761128 crovalimab Piasky Genentech 6/20/2024 intravenous
Monoclonal_antibody_therapy
Sendai virus, virus of rodents
Noguchi M, Sato N, Sugimori H, Mori K, Oshimi K (October 2001). "A minor E-selectin ligand, CD65, is critical for extravascular infiltration of acute myeloid
Murine_respirovirus
Protein-coding gene in humans
(1999). "L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein
CHST2
Protein with oligosaccharide modifications
proteins of coldwater fish Interact with specific carbohydrates Lectins, selectins (cell adhesion lectins), antibodies Receptor Various proteins involved
Glycoprotein
Protein-coding gene in humans
neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding". Journal of Immunology. 178 (12): 8053–63. doi:10.4049/jimmunol
ADAM8
Class of chemical compounds
is employed. This polySia linkage is found in proteins such as NCAM, E-selectin ligand 1 (ESL-1), C–C chemokine receptor type 7 (CCR7), synaptic cell adhesion
Polysialic_acid
Type of membrane protein that is permanently attached to the biological membrane
cell adhesion molecules (CAMs) such as integrins, cadherins, NCAMs, or selectins Some types of receptor proteins Glycophorin Rhodopsin Band 3 CD36 Glucose
Integral_membrane_protein
Mammalian protein found in Homo sapiens
Kassell NF, Lee KS (Oct 1998). "Detection of soluble E-selectin, ICAM-1, VCAM-1, and L-selectin in the cerebrospinal fluid of patients after subarachnoid
ICAM-1
Medical condition
progression and spread of various types of cancers; 4) overexpression of the P-selectin glycoprotein ligand-1 gene whose protein product promotes cell attachment
Primary_effusion_lymphoma
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