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Group of adverse drug reactions involving the skin and mucosa
Severe cutaneous adverse reactions (SCARs) are a group of potentially lethal adverse drug reactions that involve the skin and mucous membranes of various
Severe cutaneous adverse reactions
Severe_cutaneous_adverse_reactions
Skin disease
toxic epidermal necrolysis in a group of conditions known as severe cutaneous adverse reactions (SCARs). Treatment typically takes place in hospital such
Stevens–Johnson_syndrome
Rare reaction to certain medications
as one form of severe cutaneous adverse reactions (SCARs). In addition to DRESS, SCARs includes four other drug-induced skin reactions: the Stevens–Johnson
Drug rash with eosinophilia and systemic symptoms
Drug_rash_with_eosinophilia_and_systemic_symptoms
Severe skin reaction to medication
group of severe cutaneous adverse reactions (i.e. SCARs). The SCARs group of disorders includes four other drug-induced skin reactions: drug reaction with
Acute generalized exanthematous pustulosis
Acute_generalized_exanthematous_pustulosis
Severe skin reaction
of the skin. TEN is a type of severe cutaneous adverse reactions (SCARs), together with SJS, a SJS/TEN, and drug reaction with eosinophilia and systemic
Toxic_epidermal_necrolysis
Drugs to control and prevent gout attacks
is a severe adverse effect of allopurinol, which may cause exfoliative dermatitis, Steven-Johnson syndrome or severe cutaneous adverse reactions, leading
Gout_suppressants
Medical condition
develops one of the far more serious and potentially lethal severe cutaneous adverse reactions viz., the DRESS syndrome, Stevens Johnson syndrome, or toxic
Allopurinol hypersensitivity syndrome
Allopurinol_hypersensitivity_syndrome
(linear IgA dermatosis) Photosensitive drug reaction Red man syndrome Severe cutaneous adverse reactions (includes DRESS syndrome, Steven Johnson syndrome
List_of_skin_conditions
Medication
HLA-B*5801 allele is a genetic marker for allopurinol-induced severe cutaneous adverse reactions, including Stevens-Johnson syndrome (SJS) and toxic epidermal
Allopurinol
Molecular moiety or the drug class that uses it
they may cause a strong allergic reaction. The most serious of these are classified as severe cutaneous adverse reactions (i.e., SCARs) and include the Stevens–Johnson
Sulfonamide_(medicine)
Antibiotic medication
form of severe cutaneous adverse reactions (SCARs) in which a SCARs disorder, primarily the DRESS syndrome or a DRESS syndrome-like reaction occurs. Hemolysis
Dapsone
Form of arthritis causing swollen joints
human leukocyte antigen B (HLA-B) is strongly associated with severe cutaneous adverse reactions during treatment with allopurinol and is most common among
Gout
Topics referred to by the same term
Aggressive Reactionary System), an American combat fighting system Severe cutaneous adverse reactions, often abbreviated as SCARs, i.e. the last letter is lower
SCARS
Wakefulness-promoting medication
headache, nausea, anxiety, and insomnia. Rare but serious adverse effects include severe skin reactions such as Stevens-Johnson syndrome. Modafinil is contraindicated
Modafinil
sometimes associated with jaundice and/or liver failure) Priapism Severe cutaneous adverse reactions (including erythema multiforme, Stevens–Johnson syndrome and
List of adverse effects of paroxetine
List_of_adverse_effects_of_paroxetine
Anticonvulsant medication
a strong predictor of both mild and severe adverse reactions, such as the DRESS form of severe cutaneous reactions, to carbamazepine among Japanese, Chinese
Carbamazepine
Medical condition
In medicine, a drug eruption is an adverse drug reaction of the skin. Most drug-induced cutaneous reactions are mild and disappear when the offending drug
Drug_eruption
Human leukocyte antigen serotype
Stevens–Johnson syndrome. Allopurinol is a frequent cause of severe cutaneous adverse reactions, including drug-hypersensitivity syndrome, Stevens–Johnson
HLA-B58
Medical condition
(morbilliform). The rash may also be one of the potentially lethal severe cutaneous adverse reactions, the DRESS syndrome, Stevens–Johnson syndrome, or toxic epidermal
Anticonvulsant hypersensitivity syndrome
Anticonvulsant_hypersensitivity_syndrome
Drug class
exemplified by piroxicam: The use of NSAIDs can, rarely, trigger severe cutaneous adverse reactions such as Stevens–Johnson syndrome (SJS) and toxic epidermal
Oxicam
Adverse reaction that occurs initially at the site of an injection or infusion
Injection site reactions (ISRs) are reactions that occur at the site of injection of a drug. They may be mild or severe and may or may not require medical
Injection_site_reaction
years ago or less (2 points) Anaphylaxis occurred (2 points) Severe cutaneous adverse reaction such as SJS occurred (2 points) Treatment was required (1
Side_effects_of_penicillin
Medical condition
Vitamin K reactions are adverse side effects that may occur after injection with vitamin K. The liver utilizes vitamin K to produce coagulation factors
Vitamin_K_reaction
Viral infection of the skin
vehicle). Erythema was the most frequently reported local skin reaction. Severe local skin reactions reported by Aldara-treated subjects in the pediatric studies
Molluscum_contagiosum
Class of therapeutic drug
hypersensitivity reactions follow the ingestion of NSAIDs. These hypersensitivity reactions differ from the other adverse reactions listed here, which
Nonsteroidal anti-inflammatory drug
Nonsteroidal_anti-inflammatory_drug
Metabolic disorders in which porphyrins build up in the body
disorders in which substances called porphyrins build up in the body, adversely affecting the skin or nervous system. The types that affect the nervous
Porphyria
Chemotherapy and immunosuppressant medication
a variety of cutaneous side effects, particularly when administered in high doses. Another little-understood but serious possible adverse effect of methotrexate
Methotrexate
Autoimmune skin condition
Discoid lupus erythematosus is the most common type of chronic cutaneous lupus (CCLE), an autoimmune skin condition on the lupus erythematosus spectrum
Discoid_lupus_erythematosus
Beta-lactam antibiotic
intravenous injection lasting from a couple of seconds to a few minutes. Common adverse effects include nausea and rash. It may also increase the risk of yeast
Amoxicillin
Protein-coding gene in the species Homo sapiens
(March 2005). "HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol". Proceedings of the National Academy
HLA-B
Humanized monoclonal antibody
Meta-Analysis of Injection Site Reactions in Randomized-Controlled Trials of Biologic Injections". Journal of Cutaneous Medicine and Surgery. 27 (4): 358–367
Risankizumab
Skin disease characterized by red, raised, and itchy bumps
[citation needed] Severe reactions can be seen with exposure to cold water; swimming in cold water is the most common cause of a severe reaction. This can cause
Hives
Infection caused by Bacillus anthracis bacteria
reactogenicity (erythema, induration, soreness, fever) and serious adverse reactions occur in about 1% of recipients. The American product, BioThrax, is
Anthrax
Pharmaceutical drug
includes warnings and precautions for immune-mediated adverse reactions, infusion-related reactions, complications of allogeneic hematopoietic stem cell
Cemiplimab
Antifungal medication
cough, rash, and elevated liver enzymes. Severe side effects include liver problems and allergic reactions. Liver injury is, however, unusual. Oral use
Terbinafine
Skin condition, usually on the face
is a severe rosacea that can mimic acne conglobata, with hemorrhagic nodular abscesses and indurated plaques. Phymatous rosacea is a cutaneous condition
Rosacea
Mohammadi, Mahmoud; Ashrafi, Mahmoud; Moin, Mostafa (2009-11-01). "Severe cutaneous reactions caused by barbiturates in seven Iranian children". International
List of SJS-inducing substances
List_of_SJS-inducing_substances
Skin cancer originating in melanocytes
However, combination therapy also has a higher risk of immune-related adverse reactions (due to hyperactivity of the immune system). Ongoing research is looking
Melanoma
Serum sickness–like reactions (SSLRs) are adverse reactions that have symptoms similar to those of serum sickness (type III immune complex hypersensitivity)
Serum_sickness-like_reaction
Drugs that modify immune system response
tuberculosis. Common adverse effects of biologic administration are injection site reactions including redness, pain, and itching. Other adverse effects include
Biological_response_modifier
Chemotherapy medication
there is a cautionary warning: "Increased risk of serious or fatal adverse reactions in patients with low or absent Dipyrimidine Dehydrogenase activity:
Fluorouracil
Adverse reaction to smallpox vaccine
Eczema vaccinatum is a rare severe adverse reaction to smallpox vaccination, caused by exposure to replicating live vaccinia virus. It arises when vaccinia
Eczema_vaccinatum
Pair of enantiomers
with adverse effects as second primary malignancy, severe cutaneous reactions, hypersensitivity reactions, tumor lysis syndrome, tumor flare reaction, hypothyroidism
Lenalidomide
syndrome/drug reaction with eosinophilia and systemic symptoms: survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR)"
P-i_mechanism
never approved for marketing in the United States or Europe. Adverse drug reaction Adverse events European Medicines Agency Food and Drug Administration
List_of_withdrawn_drugs
Chemical compound
as leishmaniasis. Paromomycin was demonstrated to be effective against cutaneous leishmaniasis in clinical studies in the USSR in the 1960s, and in trials
Paromomycin
Adverse reaction to HIV/AIDS treatment
most notably, antiretrovirals, have an increased incidence of adverse cutaneous drug reactions in HIV-positive individuals, and even greater escalation of
HIV disease–related drug reaction
HIV_disease–related_drug_reaction
Abnormal formation of clumps of inflammatory cells (granulomata)
functioning in people with sarcoidosis without adverse effects. Inspiratory muscle training has also decreased severe fatigue perception in subjects with early
Sarcoidosis
Allergic or pseudoallergic drug reaction
Hypersensitivity reactions are idiosyncratic reactions to a drug. Although the term NSAID was introduced to signal a comparatively low risk of adverse effects
NSAID hypersensitivity reactions
NSAID_hypersensitivity_reactions
Nonsteroidal anti-inflammatory drug
PMID 18193504. Ward KE, Archambault R, Mersfelder TL (February 2010). "Severe adverse skin reactions to nonsteroidal antiinflammatory drugs: A review of the literature"
Ibuprofen
Medical condition
will experience adverse effects from all or even any of these foods. Reactions may be associated with one type of food, with new reactions to other foods
Oral_allergy_syndrome
Medication for treating fungal infections
shape, and discoloration. The above adverse reactions are usually mild and self-terminating. They are rarely severe enough to require discontinuation of
Topical_antifungal
Chemical compound
genotyping prevalence and the association with allopurinol-induced severe cutaneous adverse reactions: a living systematic review and meta-analysis". Scientific
Benzbromarone
Endocrine disorder
Kuo B, Koransky A, Vaz Wicks CL (2023-03-01). "Adrenal Crisis as An Adverse Reaction to Zoledronic Acid in a Patient With Primary Adrenal Insufficiency:
Addison's_disease
Overview of health effects resulting from tattooing
However, some allergic reactions have been medically documented. No estimate of the overall incidence of allergic reactions to tattoo pigments exists
Health_effects_of_tattoos
Monoclonal antibody against IL-17
site reactions are common, occurring in approximately 1.9% of cases. In clinical trials there were rare instances of hypersensitivity reactions, severe infections
Secukinumab
Opioid medication
opioids, causing sedation and analgesia at clinical doses. The most common adverse effects are respiratory depression, emesis, and asthenia. Bradycardia and
Fentanyl
Medication primarily used to treat severe acne
suicidal ideation, suicide attempts, and suicide. In a total of 5577 adverse reactions reported to the UK's MHRA up to 31 March 2017, the plurality (1207
Isotretinoin
Anti-diabetic and anti-obesity medication
US FDA Adverse Event Reporting System suggests an association between several GLP-1 agonists (including semaglutide) and cutaneous reactions, such as
Semaglutide
Pharmaceutical drug
months (0.7–5.6). In Study 302, serious adverse reactions included capillary leak syndrome, infusion-related reactions, sepsis, skin infection, pyrexia, and
Denileukin_diftitox
Medical condition
non-immune-mediated reaction, does not depend on prior exposure. Symptoms of drug hypersensitivity reactions can be similar to non-allergic adverse effects. Common
Drug_allergy
Medical condition
triggers of disease activity include heat and sweating, sunlight, and adverse reaction to medications as well as ionizing radiation, end-stage renal disease/hemodialysis
Transient acantholytic dermatosis
Transient_acantholytic_dermatosis
Reddening, swelling, numbness and skin peeling due to chemotherapy
chemotherapy, the reaction will appear more quickly, be more severe and will take longer to heal. Acral erythema is a common adverse reaction to cytotoxic
Chemotherapy-induced acral erythema
Chemotherapy-induced_acral_erythema
Biopharmaceutical drug for autoimmune disorders
outcomes in fever resolution and fewer severe adverse effects such as hemolytic anemia. Infliximab has adverse effects, some life-threatening, common
Infliximab
Inflammation due to damage of skin capillaries when blood perfuses into nearby tissue
Wollina U, Karadağ AS, Rowland-Payne C, Chiriac A, Lotti T (2020). "Cutaneous signs in COVID-19 Patients: a review". Dermatologic Therapy. 33 (5) e13549
Chilblains
Class of drugs used to treat malignant tumors
likely to cause hypersensitivity reactions when administered intravenously. Paclitaxel’s hypersensitivity reactions may be related to the excipient polyoxyethylated
Antineoplastic
Autoimmune disease in which the immune system attacks healthy tissue
main categories of lesions are chronic cutaneous (discoid) lupus, subacute cutaneous lupus, and acute cutaneous lupus. People with discoid lupus may exhibit
Lupus
Chemical compound
Romidepsin, sold under the brand name Istodax, is an anticancer agent used in cutaneous T-cell lymphoma (CTCL) and other peripheral T-cell lymphomas (PTCLs).
Romidepsin
Medical condition
One of the most prevalent forms of adverse drug reactions is cutaneous reactions, with drug-induced urticaria ranking as the second most common type,
Drug-induced_urticaria
Medication
pain, joint pain, vomiting, and hair loss. Severe side effects include splenic rupture and allergic reactions. It is unclear if use in pregnancy is safe
Filgrastim
Monoclonal antibody
Meta-Analysis of Injection Site Reactions in Randomized-Controlled Trials of Biologic Injections". Journal of Cutaneous Medicine and Surgery. 27 (4): 358–367
Guselkumab
Taiwanese physician scientist
(15 March 2005). "HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol". Proceedings of the National Academy
Yuan-Tsong_Chen
Medical test to determine substances causing allergic reactions
January 14, 2022. Mahajan VK, Handa S (2013). "Patch testing in cutaneous adverse drug reactions: Methodology, interpretation, and clinical relevance". Indian
Patch_test
Overview of toxicology of imported fire ant venom
States, suffering reactions that vary from mild discomfort, to pustule formation, swelling, and in rare cases, systemic reactions followed by anaphylactic
Toxicology of red imported fire ant venom
Toxicology_of_red_imported_fire_ant_venom
Allergic reaction to low temperatures
severe anaphylactic reactions, a prescribed medicine such as doxepin, taken daily, should help to prevent and/or lessen the likelihood of a reaction and
Cold_urticaria
Medical condition
after a return to euthermia is a form of IRIS. List of cutaneous conditions Jarisch–Herxheimer reaction, another systemic inflammatory syndrome that arises
Immune reconstitution inflammatory syndrome
Immune_reconstitution_inflammatory_syndrome
Vaccine
(injection-site) adverse reactions observed in clinical studies were tenderness, pain, erythema and arm motion limitation. The most common (>5%) systemic adverse reactions
Anthrax_vaccine_adsorbed
Most common form of cutaneous T-cell lymphoma
Alibert-Bazin syndrome or granuloma fungoides, is the most common form of cutaneous T-cell lymphoma. It generally affects the skin, but may progress internally
Mycosis_fungoides
Bacterial disease
formulations that produced durable protective immunity while minimizing adverse reactions to the toxin–antitoxin complex. This mixture, TAT (for toxin-antitoxin)
Diphtheria
Result of nuclear radiation exposure
Wagner, L. K.; McNeese, M. D.; Marx, M. V.; Siegel, E. L. (1999). "Severe skin reactions from interventional fluoroscopy: case report and review of the literature"
Acute_radiation_syndrome
Withdrawn NSAID analgesic medication
government and the United States Food and Drug Administration (US FDA) of adverse effects and deaths linked to the drug. Benoxaprofen was discovered by a
Benoxaprofen
Monoclonal antibody medication
per 1,000. A Cochrane review found injection site reactions to be the main reported adverse reaction. Limited studies are available to confirm whether
Omalizumab
Biopharmaceutical for autoimmune diseases
Meta-Analysis of Injection Site Reactions in Randomized-Controlled Trials of Biologic Injections". Journal of Cutaneous Medicine and Surgery. 27 (4): 358–367
Etanercept
Clinical treatment of skin conditions
stimulus and influences cellular metabolism by initiating photo-biochemical reactions within cells. Light Emitting Diode Therapy (LEDT) encompasses two primary
Light-emitting_diode_therapy
Antibiotic medication
[citation needed] Other adverse effects include: Liver toxicity—hepatitis, liver failure in severe cases Respiratory—breathlessness Cutaneous—flushing, pruritus
Rifampicin
Autoimmune diseases of the skin
guttate psoriasis), nail fungus (may be confused with nail psoriasis) or cutaneous T cell lymphoma (50% of individuals with this cancer are initially misdiagnosed
Psoriasis
Autoimmune disease of skin and connective tissue characterized by large blisters
may be appropriate. Some of these medications have the potential for severe adverse effects such as kidney and liver damage, increased susceptibility to
Bullous_pemphigoid
Human viral disease
August 2006. "Is Necrotizing Fasciitis a complication of Chickenpox of Cutaneous Vasculitis?". atmedstu.com. Archived from the original on 15 April 2008
Chickenpox
Medical condition
onychomycosis: highlights of the Third Annual International Summit on Cutaneous Antifungal Therapy". Clinical Infectious Diseases. 23 (2): 305–13. doi:10
Onychomycosis
Chemical compound
usefulness of patch testing on the previously most severely affected site in a cutaneous adverse drug reaction to tetrazepam". Contact Dermatitis. 44 (4): 259–60
Tetrazepam
Medication for parasite infestations
Boussinesq M, Bertout S, Faillie JL, Chesnais CB (April 2021). "Serious adverse reactions associated with ivermectin: A systematic pharmacovigilance study in
Ivermectin
Chemical compound
toxic epidermal necrolysis, Stevens–Johnson syndrome, cutaneous lupus erythematosus, severe infection, interstitial lung disease, cirrhosis and liver
Leflunomide
Medical treatment
include pain at the site of injection, muscle pain, and allergic reactions. Other severe side effects include kidney problems, anaphylaxis, blood clots
Immunoglobulin_therapy
Chemical warfare agent
compound was much higher and consequently the adverse health effects upon exposure were much more severe. These symptoms presented themselves in his assistant
Mustard_gas
Chemical compound
this medication may contain inactive ingredients than can cause allergic reactions. Desonide should not be used if there is an infection or open wound in
Desonide
Treatment of cancer using drugs that inhibit cell division or kill cells
Clinical electrochemotherapy has been successfully used for treatment of cutaneous and subcutaneous tumors irrespective of their histological origin. The
Chemotherapy
Species of fungus
test has some important limitations. Cross reactions with other fungal species as well as positive reactions in healthy individuals have been observed
Sporothrix_schenckii
Skin condition characterized by pimples
the evening the overwhelming majority of patients experienced no cutaneous adverse events throughout the study. It was concluded that using ceramide
Acne
Nonsteroidal anti-inflammatory medication
inducing cutaneous reactions among persons who have a history of such reactions to aspirin or nonselective NSAIDs. NSAIDs may cause serious skin adverse events
Celecoxib
Rough skin induced by UV exposure
reported rates of adverse reactions with the 3.75% cream: 19% of individuals using Imiquimod 3.75% cream reported adverse reactions including local erythema
Actinic_keratosis
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