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Transport protein and coding gene in humans
Ryanodine receptor 2 (RYR2) is one of a class of ryanodine receptors and a protein found primarily in cardiac muscle. In humans, it is encoded by the RYR2
Ryanodine_receptor_2
Class of intracellular transport proteins
Ryanodine receptors (RyR) are classified as high-conductance, intracellular calcium release channels, typically present in the membrane of the sarcoplasmic
Ryanodine_receptor
Protein and coding gene in humans
Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is one of a class of ryanodine
Ryanodine_receptor_1
Transport protein and coding gene in humans
Ryanodine receptor 3 is one of a class of ryanodine receptors and a protein that in humans is encoded by the RYR3 gene. The protein encoded by this gene
Ryanodine_receptor_3
Chemical compound
in 1997. The compound has extremely high affinity to the open-form ryanodine receptor, a group of calcium channels found in skeletal muscle, smooth muscle
Ryanodine
Family of transport proteins
triggers calcium release from the sarcoplasmic reticulum by activating ryanodine receptor 2 (RyR2) (calcium-induced-calcium-release). Phosphorylation of these
L-type_calcium_channel
Antiarrhythmic medication
flecainide is useful to break a tachyarrhythmia. Flecainide also inhibits ryanodine receptor 2 (RyR2), a major regulator of sarcoplasmic release of stored calcium
Flecainide
Breed of fast-growing chicken
Abdi-Hachesoo, B. (2019-06-25). "Sequence and expression analysis of cardiac ryanodine receptor 2 in broilers that died from sudden death syndrome". Avian Pathology
Cobb_500
Group of membrane channel proteins
The ryanodine-inositol 1,4,5-triphosphate receptor Ca2+ channel (RIR-CaC) family includes Ryanodine receptors and Inositol trisphosphate receptors. Members
Ryanodine-Inositol 1,4,5-triphosphate receptor calcium channels
Ryanodine-Inositol_1,4,5-triphosphate_receptor_calcium_channels
Species of shark
relative to other sharks. Their homeothermy may also rely on SERCA2 and ryanodine receptor 2 protein expression, which may have a cardioprotective effect. North
Salmon_shark
Class of transport proteins
significant homology with the much larger and distantly-related ryanodine receptors. The CD contains all known ligand binding sites, including the IP3
Inositol trisphosphate receptor
Inositol_trisphosphate_receptor
Chemical compound
Chlorantraniliprole opens muscular calcium channels, in particular the ryanodine receptor, rapidly causing paralysis and ultimately death of sensitive species
Chlorantraniliprole
Breed of fast-growing chicken
growth, Cardiovascular risk, and Polymorphism in Targeted Regions of Ryanodine Receptor 2 (RYR2) gene in Three Breeds of Chickens., doi:10.21203/rs.3.rs-5790536/v1
Ross_308
Medical condition
which encodes a protein included in an ion channel known as the ryanodine receptor; this channel releases calcium from a cell's internal calcium store
Catecholaminergic polymorphic ventricular tachycardia
Catecholaminergic_polymorphic_ventricular_tachycardia
Calcium-storing organelle in muscle cells
SR/terminal cisternae through a ryanodine receptor (RyR) and is known as a calcium spark. There are three types of ryanodine receptor, RyR1 (in skeletal muscle)
Sarcoplasmic_reticulum
Type of ion channel transmembrane protein
Voltage-dependent calcium channel Receptor (biochemistry) Inositol trisphosphate receptor Metabotropic receptor Ryanodine receptor "Gene Family: Ligand gated
Ligand-gated_ion_channel
Mammalian protein found in humans
transverse tubule of muscles. In skeletal muscle it associates with the ryanodine receptor RyR1 of the sarcoplasmic reticulum via a mechanical linkage. It senses
CACNA1S
Class of insecticide
mainly against lepidoptera (caterpillars), which act on the insect ryanodine receptor. They are diamides of either phthalic acid or anthranilic acid, with
Diamide_insecticides
Medical condition
Osterziel KJ, et al. (August 2006). "Composite polymorphisms in the ryanodine receptor 2 gene associated with arrhythmogenic right ventricular cardiomyopathy"
Arrhythmogenic_cardiomyopathy
Medication class with multiple uses
the LTCC and the ryanodine receptor to increase intracellular calcium levels and cause contraction. Beta-blockade of the β1 receptor will inhibit cAMP
Beta_blocker
Chemical compound
cytoplasm. In heart muscle cells this increase in Ca2+ activates the ryanodine receptor-operated channel on the SR, results in further increases in Ca2+ through
Inositol_trisphosphate
Protein-coding gene in the species Homo sapiens
SplA/ryanodine receptor domain and SOCS box containing 3 is a protein that in humans is encoded by the SPSB3 gene. GRCh38: Ensembl release 89: ENSG00000162032
SplA/ryanodine receptor domain and SOCS box containing 3
SplA/ryanodine_receptor_domain_and_SOCS_box_containing_3
Severe reaction to general anesthesia
typically located on the long arm of chromosome 19 (19q13.2) involving the ryanodine receptor. More than 25 different mutations in this gene are linked
Malignant_hyperthermia
Protein found in humans
L-type calcium channel (LTCC) Cav1.2, the sarcoplasmic reticulum calcium release channel, and the ryanodine receptor 2 (RyR2). CALM1 disease mutations are
Calmodulin_1
Toxin
peptide (CPP); it binds with high affinity and specificity to skeletal ryanodine receptor 1 (RYR1) of the sarcoplasmic reticulum, thereby triggering calcium
Vejocalcin
Chemical compound used as insecticide
Flubendiamide is the first insecticide of the diamide class. It acts on the ryanodine receptor. A environmentally persistent metabolite of flubendiamide is quite
Flubendiamide
Protein molecule receiving signals for a cell
subunits. Type 2: G protein-coupled receptors (metabotropic receptors) – This is the largest family of receptors and includes the receptors for several hormones
Receptor_(biochemistry)
American biologist and academic (born 1952)
research investigates the function of polycystin-2, the inositol trisphosphate receptor, and the ryanodine receptor. Ehrlich was born in New London, CT in 1952
Barbara_E._Ehrlich
Chemical compound
ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. It is the primary drug used for the treatment and prevention of
Dantrolene
Toxin
The molecular weight of the toxin is 3.7 kDa. IpTxa acts on the Ryanodine receptors (RyR), which are intracellular Ca2+ release channels mainly known
Imperatoxin
Protein-coding gene in the species Homo sapiens
encoded by the SRI gene. Sorcin has been shown to interact with Ryanodine receptor 2, ANXA7 and GCA. GRCh38: Ensembl release 89: ENSG00000075142 – Ensembl
Sorcin
Chemical compound
CH2(CH=CR)2NR' → C5H3R2NR' + H− Hantzsch ester Dihydropyridine receptor Ryanodine receptor "1,4-dihydropyridine - Compound Summary". Pubchem Compound. US:
1,4-Dihydropyridine
Transdermal patch that releases caffeine into the body
adenosine receptors, caffeine also blocks the inositol trisphosphate receptor 1, the ionotropic glycine receptor, and activates ryanodine receptors. Together
Caffeine_patch
Protein-coding gene in humans
hydrophobic section and it forms a quaternary complex with the cardiac ryanodine receptor (RYR2), calsequestrin (CASQ2) and junctin proteins. The luminal (inner
Triadin
Drug for skeletal muscle function
with the release of calcium by binding to the ryanodine receptor and blocking the endogenous ligand ryanodine by competitive inhibition. Muscle that contracts
Muscle_relaxant
Activation of tension-generating sites in muscle
2010). "Ryanodine receptors: structure, expression, molecular details, and function in calcium release". Cold Spring Harbor Perspectives in Biology. 2 (11)
Muscle_contraction
Peptide toxin from the venom of the scorpion Hadrurus gertschi
venom of the scorpion Hadrurus gertschi. Hadrucalcin modifies the Ryanodine receptor channels RyR1 and RyR2, found in the sarcoplasmic reticulum, to a
Hadrucalcin
Class of transport proteins
Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. Most
Transient receptor potential channel
Transient_receptor_potential_channel
Human protein for regulating body temperature
transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein
TRPV1
Protein-coding gene in humans
receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. The protein encoded by this gene is both a receptor
ITPR2
Protein and coding gene in humans
protein isoforms with ryanodine receptor type 1: a novel mechanism for control of intracellular calcium signaling". Cell Calcium. 34 (2): 177–184. doi:10
HOMER1
Structure of muscle tissue
dihydropyridine receptors (DHPRs). Their activation causes 1) a negligible influx of calcium and 2) a mechanical interaction with calcium-conducting ryanodine receptors
Triad_(anatomy)
Protein
Pandinus imperator. IpTx A acts by modifying the activity of the type 1 ryanodine receptor of skeletal muscle. RyR controls the intracellular Ca2+ permeability
Maurocalcine
Class of G protein-coupled receptors involved in chemotaxis
cyclic ADP ribose (cADPR), a second messenger which interacts with ryanodine receptors (RyR) on the surface of the rough endoplasmic reticulum. The overall
Formyl_peptide_receptor
Protein-coding gene in the species Homo sapiens
or sarcoplasmic reticulum. AKAP6 has been shown to interact with Ryanodine receptor 2 and PDE4D3. GRCh38: Ensembl release 89: ENSG00000151320 – Ensembl
AKAP6
Intracellular communication process
internal stores found in the SR. This release may be caused by ryanodine (RYRs) or IP3 receptors. RYRs Ca2+ release is spontaneous and localized. This has
Calcium_signaling
Short peptide toxin
of a group of short, basic peptides called calcins, which bind to ryanodine receptors (RyRs) and thereby trigger calcium release from the sarcoplasmic
Intrepicalcin
Extensions in cell membrane of muscle fibres
a receptor, known as a ryanodine receptor, located on the cell's own internal calcium store, the sarcoplasmic reticulum. Activation of the ryanodine receptor
T-tubule
Biological process
activated. CICR occurs when the resulting Ca2+ influx activates ryanodine receptors on the SR membrane, which causes more Ca2+ to be released into the
Calcium-induced calcium release
Calcium-induced_calcium_release
Higher release of Calcium in cells
through an ion channel within the membrane of the SR, known as a ryanodine receptor (RyR), which opens upon activation. This process is important as it
Calcium_sparks
Protein-coding gene in the species Homo sapiens
myosin light chain 2 (MYL2), ryanodine receptor 2 (RYR2), troponin I3 (TNNI3), troponin T2 (TNNT2), tropomyosin 1 (TPM1), tropomyosin 2 (TPM2), and titin
KHDRBS3
Protein family
reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor calcium signalling. It contains 10 conserved cysteines which are all
Cysteine-rich secretory protein superfamily
Cysteine-rich_secretory_protein_superfamily
Protein-coding gene in humans
encoding different isoforms. Defective interaction between FKB1B and the ryanodine receptor is thought to be a potential mechanism underlying the arrhythmias
FKBP1B
Carcass quality condition
glycolysis and a low pH within the muscle fibers. A mutation point in the ryanodine receptor gene (RYR1) in pork, associated to stress levels prior to slaughter
PSE_meat
Protein-coding gene in the species Homo sapiens
phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell. 101 (4): 365–376
Neuropeptide Y receptor type 4
Neuropeptide_Y_receptor_type_4
Central nervous system stimulant
adenosine receptors, caffeine is an inositol trisphosphate receptor 1 antagonist and a voltage-independent activator of the ryanodine receptors (RYR1, RYR2
Caffeine
Protein-coding gene in the species Homo sapiens
the PKA catalytic subunit. PRKACG has been shown to interact with Ryanodine receptor 2. GRCh38: Ensembl release 89: ENSG00000165059 – Ensembl, May 2017
PRKACG
neurocalcin, visinin etc. All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group. Highly evolutionarily conserved
Neuronal_calcium_sensor
Abnormal depolarizations of cardiac myocytes
"Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia". Circulation. 103 (2): 196–200. doi:10
Afterdepolarization
Cascade of intracellular and molecular events for transmission/amplification of signals
triphosphate on its cytosolic side; and the ryanodine receptor named after the alkaloid ryanodine, similar to the InsP3 receptor but having a feedback mechanism that
Signal_transduction
Ion channel complex through which calcium ions pass
charged ions including calcium to pass through. These include P2X receptors, Transient Receptor Potential (TRP) channels, Cyclic nucleotide-gated (CNG) channels
Calcium_channel
Protein-coding gene in humans
"Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro". The Journal of Biological
CALM2
increase in Ca2+ then binds to and activates another receptor, called a type 2 ryanodine receptor (RyR2), located on the membrane of a structure known
Cardiac excitation-contraction coupling
Cardiac_excitation-contraction_coupling
Protein-coding gene in the species Homo sapiens
ATPase, SERCA2, and ryanodine receptors; effects that were rescued by transfection of ankyrin-B. Effects on ryanodine receptors specifically were also
Ankyrin-2
Local anaesthetic drug
tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine
Tetracaine
Repeating unit of a myofibril in a muscle cell
ryanodine receptors present on the sarcoplasmic reticulum. The inward flow of calcium from the L-type calcium channels activates ryanodine receptors to
Sarcomere
Cell-cell junction composed of innexins or connexins
renamed gap junctions to distinguish them from tight junctions. They bridge a 2-4 nm gap between cell membranes. Gap junctions use protein complexes known
Gap_junction
Medical drug
proteins including rhodopsin, the A1 adenosine receptor, the D2 receptor, the P2 receptor, and ryanodine receptors. Suramin is also an inhibitor of ABC-type
Suramin
Index of articles on biophysics
Sussman Yalow Rotating locomotion in living systems Rudolf Podgornik Ryanodine receptor 2 S-layer SCN10A SCN1B SCN2B SCN3A SCN3B SCN4B SCN7A SCN8A SCNN1A SCNN1B
Index_of_biophysics_articles
Technical group of CropLife International
derivatives 2 6 Cyenopyrafen 25 B Mitochondrial complex II electron transport inhibitors Carboxanilides 1 1 Pyflubumide 28 Ryanodine receptor modulators
Insecticide Resistance Action Committee
Insecticide_Resistance_Action_Committee
Protein and coding gene in humans
TGF-beta receptor. It also interacts with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. In mouse
FKBP1A
Protein family
Synaptotagmins such as Syt1 and Syt7 also play a role in calcium-dependent AMPA receptors exocytosis to the neuron membrane. This process initiates LTP formation
Synaptotagmin
Chemical compound
from the IP3 receptor and ryanodine receptor and this has recently been borne out by the molecular identification of the NAADP receptor as members of
Nicotinic acid adenine dinucleotide phosphate
Nicotinic_acid_adenine_dinucleotide_phosphate
Drug
provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels". Molecular Pharmacology. 74 (4): 980–989. doi:10.1124/mol
Phosphodiesterase_inhibitor
Protein and coding gene in humans
Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1, TRPA1, or The Mustard and Wasabi
TRPA1
Family of transient receptor potential cation channels in animals
TRPC is a family of transient receptor potential cation channels in animals. TRPC channels form the subfamily of channels in humans most closely related
TRPC
Family of transport proteins
TRPA is a family of transient receptor potential ion channels. The TRPA family is made up of 7 subfamilies: TRPA1, TRPA- or TRPA1-like, TRPA5, painless
TRPA_(ion_channel)
Protein-coding gene in the species Homo sapiens
T cells results in the release of annexin A1 and the expression of its receptor. This pathway seems to fine-tune the strength of TCR signalling. Higher
Annexin_A1
Autosomal dominant genetic disorder
autosomal dominant fashion. Most cases have demonstrable mutations in the ryanodine receptor type 1 (RYR1) gene, which are often de novo (newly developed). People
Central_core_disease
Subgroup of TRP cation channels named after the vanilloid receptor
TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a
TRPV
Family of enzymes
directed to specific sub-cellular locations after tethering to AKAPs. Ryanodine receptor (RyR) co-localizes with the muscle AKAP and RyR phosphorylation and
Protein_kinase_A
Junction between motor neuron and muscle fiber
access program at no cost. Neuroeffector junction Dihydropyridine receptor Ryanodine receptor Levitan I, Kaczmarek L (August 19, 2015). "Intercellular communication"
Neuromuscular_junction
Family of vertebrate proteins involved in cell division and inflammation
molecular pattern molecules (DAMPs), and knockdown of aryl hydrocarbon receptor downregulates the expression of S100 proteins in THP-1 cells. Most S100
S100_protein
Protein domain
Pan TC, Zhang RZ, Fassler R (1993). "Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus
Fibulin
Protease enzyme present in mammals and other organisms
ion channels, other enzymes, cell adhesion molecules, and cell surface receptors. This can lead to degradation of the cytoskeleton and plasma membrane
Calpain
Chemical compound
provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels". Molecular Pharmacology. 74 (4): 980–9. doi:10.1124/mol
Paraxanthine
Pesticide used against insects
rice to planthopper attacks. Diamides selectively activate insect ryanodine receptors (RyR), which are large calcium release channels present in cardiac
Insecticide
Chemical compound
produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores". Neuropharmacology. 48 (8): 1086–96. doi:10.1016/j.neuropharm
CP_55,940
Type of ion channel transmembrane protein
including: inwardly rectifying K+ channels, ryanodine-inositol 1,4,5-triphosphate receptor Ca2+ channels, transient receptor potential Ca2+ channels, polycystin
Voltage-gated_ion_channel
Chemical compound used as an insecticide
2023). "Comprehensive Overview of Diamide Derivatives Acting as Ryanodine Receptor Activators". Journal of Agricultural and Food Chemistry. 71 (8): 3620–3638
Cyantraniliprole
Protein and coding gene in humans
Information, U.S. National Library of Medicine. "PKD2 polycystin 2, transient receptor potential cation channel [Homo sapiens (human)] - Gene - NCBI".
Polycystin_2
Messenger protein
sarcoplasmic reticulum membranes. The Ca2+ channels, such as the ryanodine receptor of the sarcoplasmic reticulum, can be inhibited by calmodulin bound
Calmodulin
Protein-coding gene in the species Homo sapiens
receptor thereby activating a signaling pathway that causes the aquaporin 2 containing vesicles to fuse with the plasma membrane, so the aquaporin 2 can
Aquaporin-2
Group of voltage-gated ion channels permeable to Ca2+
which is mechanically gated to a calcium-release channel (a.k.a. ryanodine receptor, or RYR) in the sarcoplasmic reticulum (SR), causes opening of the
Voltage-gated_calcium_channel
Family of transport proteins
TRPM is a family of transient receptor potential ion channels (M standing for wikt:melastatin). Functional TRPM channels are believed to form tetramers
TRPM
Peptide hormone
increased by calcium release from intracellular stores via activation of ryanodine receptors. The calcium ion concentration in the cytosol of the beta cells can
Insulin
Protein family
transient receptor potential ion channels. The three proteins TRPML1, TRPML2 and TRPML3 are encoded by the mucolipin-1 (MCOLN1), mucolipin-2 (MCOLN2) and
TRPML
Calcium-binding protein
forms of calsequestrin have been identified. The cardiac form Calsequestrin-2 (CASQ2) is present in cardiac and slow skeletal muscle and the fast skeletal
Calsequestrin
adenosine triphosphate (ATP), which activate purinergic receptors. On the other hand, purinergic receptor activation can also lead to the opening of the channel
Membrane_channel
Family of transport proteins
TRPP (transient receptor potential polycystic) is a family of transient receptor potential ion channels which when mutated can cause polycystic kidney
TRPP
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RYANODINE RECEPTOR-2
RYANODINE RECEPTOR-2
Boy/Male
Muslim
Acceptor. Next. Able.
Boy/Male
Indian, Sanskrit
Preceptor; Teacher; Well Read; Wise
Boy/Male
Muslim
Acceptor of repentance
Boy/Male
Indian
Acceptor of repentance
Boy/Male
Arabic
Educator; Preceptor
Boy/Male
Tamil
Jagatguru | ஜகதகà¯à®°à¯
Preceptor of the world
Jagatguru | ஜகதகà¯à®°à¯
Boy/Male
Tamil
Jagadguru | ஜகதகà¯à®°à¯
Preceptor of the universe
Jagadguru | ஜகதகà¯à®°à¯
Boy/Male
Arabic
Acceptor; Next; Able
Boy/Male
Indian, Sanskrit
Preceptor of the Gods
Boy/Male
Indian, Sanskrit
The Preceptor
Boy/Male
Tamil
Skandaguru | ஸà¯à®•à¯à®¨à¯à®¤à®•à¯à®°à¯à®‚
Preceptor of Skanda
Skandaguru | ஸà¯à®•à¯à®¨à¯à®¤à®•à¯à®°à¯à®‚
Boy/Male
Hindu
Preceptor of Skanda
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Telugu
Preceptor of the World
Boy/Male
Hindu, Indian, Sanskrit
Preceptor of the Gods
Boy/Male
Hindu
Preceptor of all
Boy/Male
Hindu
Preceptor of the universe
Boy/Male
Hindu
Acceptor of gunas
Boy/Male
Tamil
Gunagrahin | கà¯à®¨à®¾à®•à¯à®°à®¹à¯€à®¨
Acceptor of gunas
Gunagrahin | கà¯à®¨à®¾à®•à¯à®°à®¹à¯€à®¨
Boy/Male
Tamil
Sarvacharya | ஸரà¯à®µà®¾à®šà®¾à®°à¯à®¯
Preceptor of all
Sarvacharya | ஸரà¯à®µà®¾à®šà®¾à®°à¯à®¯
Boy/Male
British, English, Indian, Sanskrit
Learn; Understand; Perceptor
RYANODINE RECEPTOR-2
RYANODINE RECEPTOR-2
RYANODINE RECEPTOR-2
RYANODINE RECEPTOR-2
RYANODINE RECEPTOR-2
RYANODINE RECEPTOR-2
RYANODINE RECEPTOR-2
n.
The act of receiving; receipt; admission; as, the reception of food into the stomach; the reception of a letter; the reception of sensation or ideas; reception of evidence.
n.
One who gives commands, or makes rules; specifically, the master or principal of a school; a teacher; an instructor.
n.
Receptacle.
n.
Treatment; reception; entertainment.
n.
An exceptor.
n.
Acceptance; reception; favorable reception or regard; state of being acceptable.
n.
An acceptor.
n.
A religious house of the Knights Templars, subordinate to the temple or principal house of the order in London. See Commandery, n., 2.
n.
The leader of the congregational singing in Scottish and other churches.
n.
The head of a preceptory among the Knights Templars.
a.
Preceptive.
n.
Reception of strangers; hospitality.
a.
Of or pertaining to a preceptor.
n.
Reception; a taking in.
v. i.
Reception; currency.
n.
One who receipts; specifically (Law), one who receipts for property which has been taken by the sheriff.
n.
One who recaptures; one who takes a prize which had been previously taken.
pl.
of Preceptory
n.
The act or manner of receiving, esp. of receiving visitors; entertainment; hence, an occasion or ceremony of receiving guests; as, a hearty reception; an elaborate reception.
n.
The chief elective officer of some universities, as in France and Scotland; sometimes, the head of a college; as, the Rector of Exeter College, or of Lincoln College, at Oxford.
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