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Tamoxifen-induced gene expression is a method used in molecular biology and neuroscience to activate transcription of a specific gene by application of
Tamoxifen-induced gene expression
Tamoxifen-induced_gene_expression
Selective estrogen receptor modulator
353. PMID 12618500. "New Mechanism Predicts Tamoxifen Response: PAX2 gene implicated in tamoxifen-induced inhibition of ERBB2/HER2-mediated tumor growth"
Tamoxifen
Method of inducible gene expression
results. Mouse models of breast cancer metastasis Gene trapping Tamoxifen-induced gene expression Gossen M, Freundlieb S, Bender G, Müller G, Hillen
Tetracycline-controlled transcriptional activation
Tetracycline-controlled_transcriptional_activation
Mammalian protein found in Homo sapiens
level of ER expression, PIP appears to play an important role in proliferation and invasion as well as acquired resistance to tamoxifen. GRCh38: Ensembl
Prolactin-induced_protein
Negative regulation (or limiting) of body weight and cell proliferation
proliferation. This gene also has a role in the formation of some cancers and in the regulation of gene expression. The H19 gene is expressed exclusively
H19_(gene)
Mammalian protein found in humans
this desired effect. The expression of HER2 is regulated by signaling through estrogen receptors. Normally, estradiol and tamoxifen acting through the estrogen
HER2
Surname list
Radiofréquence) CreERT2, a modified estrogen receptor engineered for tamoxifen-induced gene expression This page lists people with the surname Creer. If an internal
Creer
Enzyme that metabolizes substances by oxidation
reaction due to CYP3A4 includes tamoxifen, which is hydroxylated to 4-hydroxy-tamoxifen and then dehydrated to 4-hydroxy-tamoxifen quinone methide. Two mechanisms
CYP3A4
Genetic engineering technique
floxed gene to be inactivated in the heart alone. Further, these knockouts can be made inducible. In several mouse studies, tamoxifen is used to induce the
Floxing
Protein-coding gene in the species Homo sapiens
temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia-induced gene expression patterns
Apolipoprotein_D
Structure formed early in vertebrate limb development
factors to obtain their forelimb or hindlimb identity; Hox gene expression influences expression of T-box proteins that, in turn, determine limb identity
Limb_bud
Medical classification system
type, the grade of the tumor, the stage of the tumor, and the expression of proteins and genes. As knowledge of cancer cell biology develops these classifications
Breast_cancer_classification
Site-specific recombinase technology
mice expressing CreERt2 recombinase induced by tamoxifen administration, under the control of a promoter of a gene that marks the specific cell type of
Cre-Lox_recombination
Protein found in humans
(October 2001). "Activation of phospholipase C induces the expression of the multidrug resistance (MDR1) gene through the Raf-MAPK pathway". Molecular Pharmacology
P-glycoprotein
Protein-coding gene in the species Homo sapiens
in vivo studies responding to tamoxifen adjuvant therapy, so AGR2 is likely provides an agonistic effect on tamoxifen. Therefore, AGR2 is a possible
AGR2
Signaling within the same cell
secretion induced by HER2 overexpression activated STAT3 and altered gene expression, resulting in an autocrine loop of IL-6/STAT3 expression. Both mouse
Autocrine_signaling
Mammalian protein found in Homo sapiens
AGTCAAAT that binds to their target genes and activates or deactivates certain expressions. These gene expressions then lead to phenotypic changes in stem
Oct-4
Protein found in humans
Bushel PR, et al. (February 2003). "Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cells". Molecular
Cyclin_D1
Mammalian protein found in Homo sapiens
localization of PLP1 contributes to tamoxifen resistance via excessive activation of the AKT pathway and cytoplasmic PELP1 induces signaling pathways that converge
PELP-1
Transcription factor gene of the SOX family
for producing induced pluripotent stem cells. The discovery that expression of only four transcription factors was necessary to induce pluripotency allowed
SOX2
Protein-coding gene in humans
pro-proliferation gene. These genes are normally tightly regulated, but when bound to a minimally regulated gene like SQSTM1, they cause abnormal over-expression. ENSG00000284099
Sequestosome_1
Medical condition
estrogen receptor expression in MBC has led to commonly treating these men with a selective estrogen receptor modulator, tamoxifen. Tamoxifen acts indirectly
Male_breast_cancer
Protein-coding gene in the species Homo sapiens
also associated with resistance to tamoxifen and to cytotoxic chemotherapy. In lung cancer, brachyury expression is associated with recurrence and decreased
T-box_transcription_factor_T
Protein found in humans
or Cysteine-rich angiogenic inducer 61 (CYR61), is a matricellular protein that in humans is encoded by the CCN1 gene. CCN1 is a secreted, extracellular
CCN_family_member_1
Protein found in humans
the upregulation of gene expression. The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment
Nuclear receptor coactivator 3
Nuclear_receptor_coactivator_3
Protein-coding gene in the species Homo sapiens
prolactin in primate mammary tissue: reversal by antiestrogens LY 156758 and tamoxifen". Proceedings of the National Academy of Sciences of the United States
Α-Lactalbumin
Protein found in humans
with colon cancer risk. Reduced expression of IRS-1 in Apc (min/+) mutated mice shows increased irradiation-induced apoptosis in crypt. Deficiency in
Insulin_receptor_substrate_1
Genetic recombination enzyme
the phage. Inducible Cre activation is achieved using CreER (estrogen receptor) variant, which is only activated after delivery of tamoxifen. This is done
Cre_recombinase
Protein that regulates the rate of DNA transcription
the adjacent gene is either up- or down-regulated. Transcription factors use a variety of mechanisms for the regulation of gene expression. These mechanisms
Transcription_factor
Hormone therapy for cancer
(hormone antagonists). Because steroid hormones are powerful drivers of gene expression in certain cancer cells, changing the levels or activity of certain
Hormonal_therapy_(oncology)
Protein found in humans
effect of dexamethasone on calcium-processing gene expressions is associated with a glucocorticoid-induced calcium-absorbing disorder". Life Sciences. 85
TRPV6
Mammalian protein found in humans
Paakki P, et al. (February 1998). "Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium"
Cholesterol side-chain cleavage enzyme
Cholesterol_side-chain_cleavage_enzyme
Breast cancer cell line
"Vitamin C suppresses cell death in MCF-7 human breast cancer cells induced by tamoxifen: Abstract". J Cell Mol Med. 18 (2): 305–313. doi:10.1111/jcmm.12188
MCF-7
Protein found in humans
cimetidine, ranitidine, clozapine, methimazole, itopride, ketoconazole, tamoxifen and sulindac sulfide; and agrichemicals, such as organophosphates and
Flavin-containing monooxygenase 3
Flavin-containing_monooxygenase_3
Protein found in humans
with ablation of N-cadherin in adult hearts via a cardiac-specific tamoxifen-inducible Cre N-cadherin transgene showed disrupted assembly of intercalated
Cadherin-2
Mammalian protein found in humans
breast cancer cell lines enhances estrogen-dependent gene expression, causing resistance to tamoxifen and estrogen deprivation. Consistent with co-repressor
Neurofibromin
Rare genetic disorder that affects bones and skin
found for steroids, which was the rationale to use tamoxifen, an estrogen receptor antagonist. Tamoxifen and several of its metabolites competitively bind
Pachydermoperiostosis
Enzyme protein
lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics
CYP2C9
Protein-coding gene in the species Homo sapiens
enhancing Tamoxifen's effect and preventing resistance to Tamoxifen by repressing genes that could allow for resistance. Approximately 40% of the genes affected
BASP1
Protein found in humans
receptor that regulates many dopamine-related genes, can bind the promoter region of this gene and induce expression. This promoter may also be the target of
Dopamine_transporter
Protein-coding gene in the species Homo sapiens
"Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance". Journal of Clinical Oncology. 27 (4):
BCAR1
resistance, have induced cell motility and constitutive expression of ER target genes. Finally, it has been shown that there can be ESR1 gene amplification
Endocrine therapy resistance in breast cancer
Endocrine_therapy_resistance_in_breast_cancer
Protein-coding gene in the species Homo sapiens
postmenopausal women receiving hormone replacement therapy. Abnormalities in gene expression associated with ERβ have also been linked to autism spectrum disorder
Estrogen_receptor_beta
Protein-coding gene in the species Homo sapiens
supply in mice; 4) chronic sleep deprivation-induced inflammation of visceral fat tissues in mice; 5) diet-induced inflammation in the islets of the pancreas
Free_fatty_acid_receptor_4
Protein-coding gene in the species Homo sapiens
two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen".
IL17RB
Mammalian protein found in Homo sapiens
expression and the JNK signaling pathway. C-jun protects cells from UV-induced apoptosis, and it cooperates with NF-κB to prevent apoptosis induced by
Transcription_factor_Jun
Enzyme in the human body
other lipids. CYP1A2 localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are
CYP1A2
Short RNA molecule
RNA molecule, encoded by the MIR489 gene. MicroRNAs function is to regulate the expression levels of other genes by several mechanisms. microRNAs (miRNAs)
Mir-489 microRNA precursor family
Mir-489_microRNA_precursor_family
Genome engineering tools
in animals untreated with tamoxifen. The temporal control of SSR activity by tamoxifen permits genetic changes to be induced later in embryogenesis and/or
Site-specific recombinase technology
Site-specific_recombinase_technology
Protein-coding gene in humans
recognized by the macrophage glycoreceptor CLEC10A (MGL) are induced by 4-hydroxy-tamoxifen, oxidative stress and DNA-damage in breast cancer cells". Cell
CLEC10A
through its expression in the hippocampus and the amygdala. Studies supporting the role of CREB in cognition include those that knock out the gene, reduce
CREB_in_cognition
Protein-coding gene in the species Homo sapiens
It is a developmentally important retinoic acid-responsive gene product strongly induced during mid-gestation, hence the name midkine. Restricted mainly
Midkine
Protein-coding gene in the species Homo sapiens
acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity
BCAS3
rifampicin has been found to induce MDR1 expression. Experiments in different drug resistant cell lines and patient DNA revealed gene rearrangements which had
Antineoplastic_resistance
Protein-coding gene in humans
lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics
CYP2B6
Method for lineage tracing using CRISPR-Cas9-edited barcodes
event is induced via microinjection like traditional GESTALT, while a subsequent second labeling period is initiated by heat shock-induced expression of Cas9
GESTALT
Impaired flow of bile from the liver to the small intestine
hepatocytes showed decreased expression of BSEP mRNA and protein following long-term exposure to metformin and tamoxifen, neither of which are direct
Cholestasis
Human liver enzyme
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed
CYP2D6
Protein-coding gene in the species Homo sapiens
Besides estrogens, selective estrogen receptor modulators (SERMs) like tamoxifen increase PZP levels. The synthetic estrogen ethinylestradiol (EE) shows
Pregnancy_zone_protein
Accumulation of mutations
"Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer". Cancer Research. 55 (15): 3331–3338
Somatic_evolution_in_cancer
Chemical compound
forskolin-mediated Notch3 expression in ADPKD (Autosomal Dominant Polycystic Kidney Disease) cells. Studies in mice pretreated with tamoxifen in order to create
Nirogacestat
French cancer physician
factors secreted and induced by estrogens. He focused the activity of his research unit on a 52 kilo-dalton glycoprotein, induced by estrogens and growth
Henri_Rochefort_(physician)
Northern Irish_American cancer researcher and academic administrator
non-nuclear activities of endocrine therapies including the effects of Tamoxifen and high dose estrogens on membrane fluidity. In his studies of drug resistance
Robert_Clarke_(academic)
Medical condition
cancer within 10 years following initial diagnosis if they did not receive tamoxifen treatment or have an oophorectomy. The woman's ten-year risk for ovarian
BRCA_mutation
Protein-coding gene in the species Homo sapiens
Polyak K (2002). "Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression)". Oncogene. 21 (5): 836–43. doi:10
EGLN2
Protein-coding gene in the species Homo sapiens
and can have a determinant effect on response to the breast cancer drug tamoxifen. ENSG00000230907, ENSG00000224200, ENSG00000223666 GRCh38: Ensembl release
FKBPL
Mammalian protein found in humans
The gene of CCL18 is most similar to CCL3. CCL18 is located on chromosome 17, along with many other macrophage inflammatory proteins (MIPs). The gene itself
CCL18
Chemical compound
conventional antiestrogens like tamoxifen (33 of 88 proteins, or 37.5%). It also induced apoptosis in breast cancer cells, unlike tamoxifen. Efforts are underway
ERX-11
Protein-coding gene in the species Homo sapiens
genistein, miroestrol) Selective estrogen receptor modulators (e.g., tamoxifen, clomifene, raloxifene) Antiestrogens (e.g., fulvestrant, ICI-164384,
Estrogen_receptor_alpha
Class of pharmaceutical drugs
estrogen receptor modulators (SERMs) became evident. The first SERM, tamoxifen, was originally developed as an anti-estrogen contraceptive. However,
Selective androgen receptor modulator
Selective_androgen_receptor_modulator
Human breast cancer line
research involves the study of resistance to Tamoxifen, a selective estrogen receptor modulator (SERM). Tamoxifen functions by inhibiting estrogen signaling
ZR-75-1
Protein-coding gene in the species Homo sapiens
activation of GPER and/or ERβ. Estradiol, as well as tamoxifen and fulvestrant, have been found to rapidly induce lordosis through activation of GPER in the arcuate
GPER
Enzyme
MacKenzie IZ, Bicknell R, Rees MC (March 2002). "Tamoxifen induction of angiogenic factor expression in endometrium". British Journal of Cancer. 86 (5):
Thymidine_phosphorylase
Protein-coding gene in humans
BCAR3 gene. Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However
BCAR3
Protein-coding gene in the species Homo sapiens
and neural tube. AP2-gamma also suppresses genes such as MYC and C/EBP alpha. It also represses CD44 expression, which is a cell marker for some breast and
TFAP2C
Mammalian protein found in humans
individual. There are many common genetic variations that affect the expression of the CYP2C19 gene, which in turn influences the enzyme activity in the metabolic
CYP2C19
Gonadotropin secreted by the adenohypophysis
(March 2018). "Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression". Molecular and Cellular Endocrinology. Signaling Pathways Regulating
Luteinizing_hormone
Protein
intracellular receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism
Nuclear_receptor
Mammalian protein found in Homo sapiens
2022). "Epigenetic repression of gonadotropin gene expression via a GnRH-mediated DNA delivery system". Gene Therapy. 29 (5): 294–303. doi:10.1038/s41434-022-00325-6
Gonadotropin-releasing hormone
Gonadotropin-releasing_hormone
Overview article
from the expression of weakly penetrant but highly prevalent mutations in various genes. For instance, polymorphism has been identified in genes associated
Risk factors for breast cancer
Risk_factors_for_breast_cancer
Albumin found in human blood
(July 2006). "All-trans retinoic acid down-regulates human albumin gene expression through the induction of C/EBPbeta-LIP". The Biochemical Journal. 397
Human_serum_albumin
Gender-affirming medical treatment
that adding androgens induced such changes, appearing to silence genes across the breast tissue, including a suppression of genes linked to breast cancer
Gender-affirming hormone therapy
Gender-affirming_hormone_therapy
Autoimmune disease
interference: Altering thyroid hormone serum transfer proteins. Estrogen, tamoxifen, heroin, methadone, clofibrate, 5-fluorouracil, mitotane, and perphenazine
Hashimoto's_thyroiditis
Gonadotropin that regulates the development of reproductive processes
subunit gene expression in female rats: actions on follicle-stimulating hormone beta messenger ribonucleic acid (mRNA) involve differential expression of pituitary
Follicle-stimulating_hormone
Group of voltage-gated ion channels permeable to Ca2+
channels, muscular contraction, excitation of neurons, up-regulation of gene expression, or release of hormones or neurotransmitters. VGCCs have been immunolocalized
Voltage-gated_calcium_channel
Human glycoprotein that binds to androgens and estrogens
(December 2007). "Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene". The Journal of Clinical Investigation
Sex_hormone–binding_globulin
Family of short non-coding RNA fragments
MB can be induced by 2 inherited cancer syndromes, one of which is called the Gorlin syndrome and is caused by a mutated PATCHED(PTCH) gene. PTCH is the
Mir-92 microRNA precursor family
Mir-92_microRNA_precursor_family
Time when menstrual periods stop permanently
symptoms can vary widely from woman to woman. Menopause can also be induced early. Induced menopause occurs as a result of medical treatment such as chemotherapy
Menopause
Family of transport proteins
2009-10-30. compilation of genetic variations in the SCN1A gene that alter the expression or function of Nav1.1 Bennett DL, Clark AJ, Huang J, Waxman
Voltage-gated_sodium_channel
Protein-coding gene in the species Homo sapiens
MTA1, MTA2 functions as a chromatin remodeling factor and regulates gene expression. MTA2 is overexpressed in human cancer and its dysregulated level correlates
MTA2
Protein-coding gene in the species Homo sapiens
method for a potential treatment of chronic pain by repressing Nav1.7 gene expression which showed therapeutic potential in three mouse models of chronic
SCN9A
Protein found in humans
receptor-gamma coactivator-1alpha regulate estrogen-related receptor-alpha gene expression via a conserved multi-hormone response element". Journal of Molecular
Estrogen-related receptor gamma
Estrogen-related_receptor_gamma
Medication to treat high blood pressure and alopecia
prostacyclin production. Additionally, expression of the prostaglandin E2 receptor, the most upregulated target gene in the β-catenin pathway of DP cells
Minoxidil
Rare human disease
has not proven consistently effective. Medical regimens have included tamoxifen, progesterone, bromocriptine, the gonadotropin-releasing hormone agonist
Breast_hypertrophy
Protein-coding gene in the species Homo sapiens
two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen".
HOXB13
MicroRNA
angiogenesis. RNA induced Silencing Complex (RISC) proteins SND1 and AEG-1 induces miR-221 expression in Liver cancer. In liver cancer miR-221 induces the tumor
Mir-221_microRNA
Transmembrane receptor found in humans
functioning during reproduction. The gene for the LHCGR is found on chromosome 2 p21 in humans, close to the FSH receptor gene. It consists of 70 kbp (versus
Luteinizing hormone/choriogonadotropin receptor
Luteinizing_hormone/choriogonadotropin_receptor
Primary female sex hormone
and activate estrogen receptors (ERs) which in turn modulate the expression of many genes. Additionally, estrogens bind to and activate rapid-signaling membrane
Estrogen
Tropane alkaloid and stimulant drug
include: Cocaine-induced midline destructive lesions (CIMDL) Nasal septum perforation Palate perforation Saddle nose Cocaine-induced midline destructive
Cocaine
Group of diseases involving cell growth
inappropriate over-expression of normal oncogenes, or by the under-expression or disabling of tumor suppressor genes. Typically, changes in multiple genes are required
Cancer
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TAMOXIFEN INDUCED-GENE-EXPRESSION
TAMOXIFEN INDUCED-GENE-EXPRESSION
TAMOXIFEN INDUCED-GENE-EXPRESSION
TAMOXIFEN INDUCED-GENE-EXPRESSION
TAMOXIFEN INDUCED-GENE-EXPRESSION
TAMOXIFEN INDUCED-GENE-EXPRESSION
TAMOXIFEN INDUCED-GENE-EXPRESSION
TAMOXIFEN INDUCED-GENE-EXPRESSION
TAMOXIFEN INDUCED-GENE-EXPRESSION
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