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Protein-coding gene in the species Homo sapiens
Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway
Complement_factor_B
Part of the immune system that enhances the ability of antibodies and phagocytic cells
of complement component 3, complement factor B, and complement factor I, as well as deletion of complement factor H-related 3 and complement factor H-related
Complement_system
Chemical compound
of paroxysmal nocturnal hemoglobinuria and proteinuria. It is a complement factor B inhibitor that was developed by Novartis. It is taken by mouth. Iptacopan
Iptacopan
Protein
Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. Complement factor I (factor I) is a protein
Complement_factor_I
Protein found in humans
Factor H (FH) is a soluble glycoprotein and a member of the regulators of complement activation (RCA) family. It functions as a complement control protein
Factor_H
Vision loss due to damage to the macula of the eye
location 10q26 Complement factor B/complement component 2 (CFB/CC2) on chromosome 6 at 6p21.3[citation needed] Polymorphisms in genes for complement system proteins:
Macular_degeneration
Class of enzymes
Factor D (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) is a protein
Factor_D
Topics referred to by the same term
basalt, large volumes of dominantly tholeiitic basalt on continents Complement factor B, a protein Compact fluorescent bulb Current feedback, a type of electronic
CFB
Mammalian protein found in Homo sapiens
Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. DAF regulates the complement
Decay-accelerating_factor
Protein found in humans
agent. Factor I can cleave C3b into C3c and C3d, the latter of which plays a role in enhancing B cell responses. In the alternative complement pathway
Complement_component_3
Type of cascade reaction of the complement system
activation process: Complement Receptor 1 (CR1 or CD35) and DAF (decay accelerating factor also known as CD55) compete with Factor B in binding with C3b
Alternative complement pathway
Alternative_complement_pathway
Blood disease in which red blood cells are attacked by the immune system
of paroxysmal nocturnal hemoglobinuria and proteinuria. It is a complement factor B inhibitor that was developed by Novartis. It is taken by mouth. Iptacopan
Paroxysmal nocturnal hemoglobinuria
Paroxysmal_nocturnal_hemoglobinuria
Protein involved in the immune system
major histocompatibility complex class III region linking complement genes C4, C2 and factor B". Nature. 307 (5948): 237–41. Bibcode:1984Natur.307..237C
Complement_component_4
Class of serine proteases
complement activation. After cleavage and binding to cell surface, the C3b fragment is ready to bind a plasma protein called Factor B. The Factor B (a
C3-convertase
Alternative-complement-pathway C3/C5 convertase (EC 3.4.21.47, complement component C3/C5 convertase (alternative), proenzyme factor B, properdin factor B, C3
Alternative-complement-pathway C3/C5 convertase
Alternative-complement-pathway_C3/C5_convertase
Protein found in humans
Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system
Complement_component_1s
Topics referred to by the same term
pathway of immune system complement activation Transcription factor, a protein that binds to specific DNA sequences Factor (programming language), a
Factor
Protein-coding gene in the species Homo sapiens
encoded by the CFP (complement factor properdin) gene. Properdin and factor H are regulatory proteins in the alternative complement pathway. Properdin
Properdin
Membrane-bound complement regulators Membrane Cofactor Protein, MCP (CD46) Decay Accelerating Factor, DAF (CD55) Protectin (CD59) Complement C3b/C4b Receptor
Complement_control_protein
760.198 – complement factor b MeSH D08.811.277.656.300.760.200 – complement factor d MeSH D08.811.277.656.300.760.210 – complement factor i MeSH D08
List_of_MeSH_codes_(D08)
regulated without C3b inactivation, through complement control proteins, including decay-accelerating factors that function to speed up C3 convertase half-lives
C3a_(complement)
Protein found in humans
"Structure and activation of complement components C2 and factor B". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Complement_component_2
Protein found in humans
glycoprotein of the complement system; decay-accelerating factor (DAF: CD55: Cromer antigen) protects host cells from complement-mediated damage by regulating
Complement_receptor_1
Protein part of the complement system
part of the complement system, a component of the vertebrate immune system. iC3b is produced when complement factor I cleaves C3b. Complement receptors
IC3b
Protein Domain
Pfam clan). The vWA domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII
Von Willebrand factor type A domain
Von_Willebrand_factor_type_A_domain
Protein domain
Von Willebrand factor, type C (VWFC or VWC)is a protein domain is found in various blood plasma proteins: complement factors B, C2, CR3 and CR4; the integrins
Von Willebrand factor type C domain
Von_Willebrand_factor_type_C_domain
Genetic process
Complementation refers to the capacity of a segment of genetic material (eg DNA) to rescue the phenotype of a mutation. It shows that a copy of the gene
Complementation_(genetics)
Macrophage-1 antigen (hereafter complement receptor 3 or CR3) (CD11b/CD18) is a human cell surface receptor found on B and T lymphocytes, polymorphonuclear
Macrophage-1_antigen
British protein biochemist, immunologist, and academic
Prosser, B. E., Johnson, S., Roversi, P., Herbert, A. P., Blaum, B. S., Tyrrell, J., ... & Lea, S. M. (2007). Structural basis for complement factor H–linked
Simon_J._Clark
Protein
also interacts with complement factor I, which is an enzyme responsible for cleaving C3b into its inactive form, iC3b. When factor I is recruited to the
Clumping_factor_A
inhibition - complement 3A - complement 5A - complement factor B - complement membrane attack complex - complement receptor - complex - computational biology
Index of biochemistry articles
Index_of_biochemistry_articles
Japanese molecular biologist
Immunology at the University of Tokyo where he investigated the complement factor B for HIV infection. In 1992, he participated in the first large-scale
Makoto_Furutani-Seiki
Medical diagnostic method
classical complement pathway and thus requires functioning C1-C9 factors. If an individual has deficient or malfunctioning complement factors, then at
Total_complement_activity
American stealth bomber aircraft
the B-21 is meant to complement the Rockwell B-1 Lancer and Northrop B-2 Spirit, replace them by 2040, and possibly replace the 1950s Boeing B-52 Stratofortress
Northrop_Grumman_B-21_Raider
Mammalian protein found in Homo sapiens
B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, is a protein that in humans
B-cell_activating_factor
Part of the innate immune system
C3b is the larger of two elements formed by the cleavage of complement component 3, and is considered an important part of the innate immune system. C3b
C3b
Topics referred to by the same term
1920s BF (protein), an initialism for B factor, a triggering protein of the alternative pathway of complement activation Bellman–Ford algorithm, a graph
BF
Life-threatening immune-related blood disease
complement regulatory proteins (e.g., factor H, factor HR1 or HR3, membrane cofactor protein, factor I, factor B, complement C3, and thrombomodulin). This results
Atypical hemolytic uremic syndrome
Atypical_hemolytic_uremic_syndrome
Protein-coding gene in the species Homo sapiens
humans is encoded by the C4B gene. This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed
Complement_component_4B
Serine protease that plays key role in innate immunity
(C3bBbC3b) of complement system. Two fluid phase C5 convertases have been described: the classical pathway enzyme, C4b2boxy3b and the cobra venom factor-dependent
C5-convertase
Overview of and topical guide to immunology
Region Fc Region Polyclonal B cell response Cell-mediated immunity Innate immune system Complement system Classical complement pathway Mannan-binding lectin
Outline_of_immunology
Protein-coding gene in humans
Complement factor H-related protein 5 is a protein that in humans is encoded by the CFHR5 gene. CFHR5 is structurally related to complement factor H which
CFHR5
Computer format for representing real numbers
fixed-point formats as a signed integer in two's complement representation with an implicit scaling factor as above. The sign of the value will always be
Fixed-point_arithmetic
Number format for specifying provision
can be seen as a 16-bit signed (two's complement) integer, that is implicitly multiplied by the scaling factor 2 − 12 {\displaystyle 2^{-12}} . In particular
Q_(number_format)
Protein fragment
mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system such as sepsis, rheumatoid
Complement_component_5a
Mathematical set formed from two given sets
complement }&A_{2}^{\complement }&\dots &A_{n}^{\complement }\\B_{1}^{\complement }&B_{2}^{\complement }&\dots &B_{n}^{\complement }\end{array}}\right[}
Cartesian_product
and B. ∁ {\displaystyle \complement } 1. With a subscript, denotes a set complement: that is, if B ⊆ A {\displaystyle B\subseteq A} , then ∁ A B =
Glossary of mathematical symbols
Glossary_of_mathematical_symbols
Protein-coding gene in humans
Complement C1r subcomponent (EC 3.4.21.41, activated complement C1r, C overbar 1r esterase, C1r) is a protein involved in the complement system of the
Complement_component_1r
Protein domain
Anaphylatoxins, or complement peptides, are fragments (C3a, C4a and C5a) that are produced as part of the activation of the complement system. Complement components
Anaphylatoxin
Protein found in humans
Complement component 9 (C9) is a MACPF protein involved in the complement system, which is part of the innate immune system. Once activated, about 12-18
Complement_component_9
Antibody isotype
elimination of the pathogen itself; IgG activates the classical pathway of the complement system, a cascade of immune protein production that results in pathogen
Immunoglobulin_G
Mammalian protein found in humans
complement system. The encoded protein has cofactor activity for inactivation (through cleavage) of complement components C3b and C4b by serum factor
Membrane_cofactor_protein
American actor (born 1973)
In 2012, he co-hosted the second season of the American version of The X Factor with Khloé Kardashian, and was the sole host for the third and final season
Mario_Lopez
Species of bacteria
plasminogen binding proteins for interference of factor H at the activation level. This is part of a complement system evasion strategy that leads to downstream
Borrelia_burgdorferi
Protein found in humans
Complement component 5 is a protein that in humans is encoded by the C5 gene. Complement component 5 is involved in the complement system. It is cleaved
Complement_component_5
American strategic bomber aircraft
will allow B-52s to quickly scan vast Pacific Ocean areas. This radar will complement the Litening infrared targeting pod already used by B-52s for inspecting
Boeing_B-52_Stratofortress
Mammalian protein found in humans
bacteria) in order to activate the complement system via C1q. CRP is synthesized by the liver in response to factors released by macrophages, T cells and
C-reactive_protein
Autoimmune disease in which the immune system attacks healthy tissue
RNASEH2C, Complement component 1qA, Complement component 1qB, Complement component 1r, Complement component 1s, Complement component 2, Complement component
Lupus
Crewed full ocean depth rated submersible
DSV. Limiting Factor was used to identify the wrecks of the destroyers USS Johnston at a depth of 6,469 m (21,224 ft), and USS Samuel B. Roberts at 6
DSV_Limiting_Factor
Aspect of the immune system
classical complement pathway is one of three pathways which activate the complement system, which is part of the immune system. The classical complement pathway
Classical_complement_pathway
Clumping of abnormal cold-sensitive proteins in blood
cryoglobulinemic disease have rheumatoid factor activity, meaning they bind to polyclonal immunoglobulins and activate the blood complement system. They therefore form
Cryoglobulinemia
Mammalian protein found in humans
Takizawa H, et al. (August 1989). "20 KDa homologous restriction factor of complement resembles T cell activating protein". Biochemical and Biophysical
CD59
Quantity in relativistic physics
The Lorentz factor or Lorentz term (also known as the gamma factor) is a dimensionless quantity expressing how much the measurements of time, length, and
Lorentz_factor
American heavy bomber aircraft
B-17 a key bomber aircraft of the war. Other factors such as combat effectiveness and political issues also contributed to the B-17's success. The B-17
Boeing_B-17_Flying_Fortress
Protein domain
proteins. Complement decay-accelerating factor (Antigen CD55) belongs to the Cromer blood group system and is associated with Cr(a), Dr(a), Es(a), Tc(a/b/c)
Sushi_domain
486.274.860.450 – complement factor d MeSH D12.776.124.486.274.900 – complement factor b MeSH D12.776.124.486.274.920 – complement inactivator proteins
List of MeSH codes (D12.776.124)
List_of_MeSH_codes_(D12.776.124)
Species of bacterium that can cause meningitis
Factor H binding protein (fHbp) that is exhibited in N. meningitidis and some commensal species is the main inhibitor of the alternative complement pathway
Neisseria_meningitidis
RNA family
innate immune response by binding Factor H, Complement component 3 and IgG. Protein A SprX Chabelskaya S, Gaillot O, Felden B (June 2010). "A Staphylococcus
SprD
of -Arg103-Ser- and -Ile124-Ile- bonds in limulus clotting factor B to form factor overbar B. Cleavage of -Pro-Arg- bonds in synthetic substrates This
Limulus_clotting_factor_C
Medical condition
glomerular mesangium and basement membrane (GBM) thickening, activating the complement system and damaging the glomeruli. MPGN accounts for approximately 4%
Membranoproliferative glomerulonephritis
Membranoproliferative_glomerulonephritis
Disease of blood and kidneys after bacterial infection
for several complement regulatory proteins. Later, mutations in complement factor H, complement factor I, membrane cofactor protein, factor B, C3, and thrombomodulin
Hemolytic–uremic_syndrome
Algebraic manipulation of "true" and "false"
enters via complement ¬ as follows. The complement operation is defined by the following two laws. Complementation 1 x ∧ ¬ x = 0 Complementation 2 x ∨ ¬
Boolean_algebra
Reaction occurring within an organism as a defence against a pathogen
neutrophils, macrophages, and monocytes, and soluble factors including cytokines and complement. On the other hand, the adaptive branch is the body's
Immune_response
Protein-coding gene in the species Homo sapiens
APOBEC1 complementation factor is a protein that in humans is encoded by the A1CF gene. Alternative splicing occurs at this locus and three full-length
A1CF
International movement of people, resources and means of production
international factor movements are movements of labor, capital, and other factors of production between countries. International factor movements occur
International factor movements
International_factor_movements
Activation of coagulation cascade
names: authors list (link) Ghebrehiwet, B; Kaplan, AP; Joseph, K; Peerschke, EI (November 2016). "The complement and contact activation systems: partnership
Contact_activation_system
Protein domain
calcium. Mammalian complement-activating component of Ra-reactive factor (RARF), a protease that cleaves the C4 component of complement. Vertebrate enteropeptidase
CUB_domain
Vitamin K-dependent plasma glycoprotein synthesized in the liver
Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In humans, protein S is encoded by
Protein_S
Immune cells found in lymph nodes
tissue, where they transfer complement opsonized antigen to the FDCs. FDCs, in turn, attract B cells with chemoattractant CXCL13. B cells lacking CXCR5, the
Follicular_dendritic_cells
Overreaction of the immune system to an antigen
a major risk factor for developing systemic lupus erythematosus. This is believed to be due to the fact that in the absence of complement components, immune
Hypersensitivity
Protein domain named after the epidermal growth factor protein
Bersch B, Hernandez JF, Marion D, Arlaud GJ (1998). "Solution Structure of the Epidermal Growth Factor (EGF)-like Module of Human Complement Protease
EGF-like_domain
Lock-and-key pairing between two structures
complementary bases (i.e. guanine = b, cytosine = q, adenine = n, and thymine = u), which makes it is possible to complement entire DNA sequences by simply
Complementarity (molecular biology)
Complementarity_(molecular_biology)
Class of molecules found in the outer membrane of Gram-negative bacteria
result are able to increase their resistance to complement-mediated killing or even down-regulate complement activation or evade the effects of bactericidal
Lipopolysaccharide
US Air Force strategic bomber (1949–1959)
damaging aircraft of the 7th and 11th Bomber Wings' complement of B-36s. Some two-thirds of the USAF's entire B-36 fleet was damaged, as well as six aircraft
Convair_B-36_Peacemaker
Technology used to validate protein interactions
Bimolecular fluorescence complementation (also known as BiFC) is a technology typically used to validate protein interactions. It is based on the association
Bimolecular fluorescence complementation
Bimolecular_fluorescence_complementation
Evolutionarily-conserved protein domain
"The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform infrared spectroscopy. Its occurrence
Von Willebrand factor type D domain
Von_Willebrand_factor_type_D_domain
Protein
S2CID 24765480. Singh B, Su YC, Riesbeck K (Nov 2010). "Vitronectin in bacterial pathogenesis: a host protein used in complement escape and cellular invasion"
Vitronectin
mediated psoriasis (CAMPS) Cherubism COPA defect Otulipenia/ORAS The complement system is part of the innate as well as the adaptive immune system; it
List of primary immunodeficiencies
List_of_primary_immunodeficiencies
Standard for miniature computer expansion cards
2 (pronounced "em-dot-two"), formerly known as the Next Generation Form Factor (NGFF), is a specification for internally mounted computer expansion cards
M.2
One of the four basic arithmetic operations
ones' complement is very easily obtained by inverting each bit (changing "0" to "1" and vice versa). And adding 1 to get the two's complement can be
Subtraction
Protein-coding gene in the species Homo sapiens
Complement component 1 Q subcomponent-binding protein, mitochondrial is a protein that in humans is encoded by the C1QBP gene. The human complement subcomponent
C1QBP
Mammalian protein found in Homo sapiens
beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A and cluster of differentiation
Integrin_alpha_M
Proteins similar to insulin that stimulate cell proliferation
be an anabolic factor for bone. Since at high concentrations it is capable of activating the insulin receptor, it can also complement for the effects
Insulin-like_growth_factor
Protein-coding gene in the species Homo sapiens
is encoded by the C4A gene. This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed
C4A
Protein-coding gene in the species Homo sapiens
recognition immune clearance, SAP binds in a calcium dependent manner to complement component C1q and the antibody binding region of immunoglobulins (Fab)
Serum_amyloid_P_component
Combinational digital circuit
A (or B) appears at Y in two's complement form. Increment: A (or B) is increased by one and the resulting value appears at Y. Decrement: A (or B) is decreased
Arithmetic_logic_unit
Buhmann, R; Simoes, B; Stanglmaier, M; Yang, T; Faltin, M; Bund, D; Lindhofer, H; Kolb, HJ; et al. (2008). "Immunotherapy of recurrent B–cell malignancies
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Biological system protecting an organism against disease
phagocytosis, antimicrobial peptides called defensins, RNA interference, and the complement system. Jawed vertebrates, including humans, have a more sophisticated
Immune_system
Physical effects resulting from activation of the immune system
to initiate and propagate the inflammatory response. These include the complement system activated by bacteria and the coagulation and fibrinolysis systems
Inflammation
Protein family
region binds and recruits the C4b-binding protein C4BP and the complement regulator Factor H, which inhibit C3 convertase, thus preventing opsonization
M_protein_(Streptococcus)
COMPLEMENT FACTOR-B
COMPLEMENT FACTOR-B
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Indian, Sanskrit
Competent
Male
Spanish
Spanish form of Roman Latin Victor, VÃCTOR means "conqueror."
Boy/Male
Arabic, Muslim
Competent
Male
Greek
(ÎαχώÏ) Greek form of Hebrew Nachowr, NACHOR means "snoring" or "snorting." In the bible, this is the name of the son of Terah and brother of Abraham.
Boy/Male
Latin
Son of Azeus.
Boy/Male
Arabic, Muslim
Competent
Male
English
 Anglicized form of Scottish Gaelic Eachann, HECTOR means "brown horse." Compare with another form of Hector.
Boy/Male
Muslim
Competent
Boy/Male
Hindi
Competent.
Male
Arthurian
, sir Hector de Maris; (defender).
Boy/Male
Anglo Saxon
Competent.
Male
English
Roman Latin name VICTOR means "conqueror."Â
Boy/Male
English American
Doctor; teacher.
Male
Spanish
Spanish name derived from Latin Pastor, PASTOR means "shepherd." St. Pastor was a 9-year-old boy who along with his 13-year-old brother, Justus, was martyred at Alcalá de Henares in the early 4th century.
Surname or Lastname
French and Italian
French and Italian : occupational name from French, northern Italian sartor ‘tailor’ (Latin sartor).English : topographic name denoting someone who lived on land which had been cleared for cultivation, Old French assart, essart ‘woodland cleared for cultivation’ + the habitational suffix -er.
Male
Greek
(ΚάστωÏ) Greek name KASTOR means "beaver." In mythology, Castor/Kastor and Pollux/Polydeukes ("very sweet") are the twin sons of Leda and are known as the Gemini twins.
Boy/Male
Arabic, Muslim
Competent
Male
Icelandic
Perhaps a modern form of Icelandic Fylkir, FALKOR means "people, tribe."Â
Boy/Male
Muslim
Compliments, Happiness
COMPLEMENT FACTOR-B
COMPLEMENT FACTOR-B
Boy/Male
Welsh
Joy.
Girl/Female
Tamil
Red lotus, Bright, Goddess Parvati
Boy/Male
Tamil
Nirjhar | நீரà¯à®œà¯à®¹à®¾à®°
Waterful
Surname or Lastname
Dutch
Dutch : from a reduced form of any of various Germanic personal names formed with the element bald (see Bald).English : variant spelling of Ball 1.Danish : habitational name from a farmstead named Balle, meaning ‘slope’, ‘hill’.Catalan : respelling of Batlle, status name for a steward or official, from Catalan batlle.
Boy/Male
Tamil
Lord Vishnu
Female
English
 Feminine form of English Albert, ALBERTA means "bright nobility." Compare with another form of Alberta.
Boy/Male
Hindu
The bow of Arjuna
Boy/Male
Indian, Tamil
Dedicated to God
Girl/Female
Hindu, Indian
Quite One
Boy/Male
Muslim
Leader
COMPLEMENT FACTOR-B
COMPLEMENT FACTOR-B
COMPLEMENT FACTOR-B
COMPLEMENT FACTOR-B
COMPLEMENT FACTOR-B
pl.
of Factum
n.
Same as Radius vector.
adv.
In fact; by the act or fact.
v. i.
To pass compliments; to use conventional expressions of respect.
v. t.
To praise, flatter, or gratify, by expressions of approbation, respect, or congratulation; to make or pay a compliment to.
n.
The body of factors in any place; as, a chaplain to a British factory.
v. t.
A compliment.
n.
A house or place where factors, or commercial agents, reside, to transact business for their employers.
n.
A letter or epistle; -- so called in civility or compliment; as, your favor of yesterday is received.
n.
One who transacts business for another; an agent; a substitute; especially, a mercantile agent who buys and sells goods and transacts business for others in commission; a commission merchant or consignee. He may be a home factor or a foreign factor. He may buy and sell in his own name, and he is intrusted with the possession and control of the goods; and in these respects he differs from a broker.
n.
See Faitour.
v. t.
To resolve (a quantity) into its factors.
imp. & p. p.
of Factor
n.
A building, or collection of buildings, appropriated to the manufacture of goods; the place where workmen are employed in fabricating goods, wares, or utensils; a manufactory; as, a cotton factory.
v. t.
To provide with an implement or implements; to cause to be fulfilled, satisfied, or carried out, by means of an implement or implements.
v. t.
The interval wanting to complete the octave; -- the fourth is the complement of the fifth, the sixth of the third.
a.
Self-satisfied; contented; kindly; as, a complacent temper; a complacent smile.
n.
An expression, by word or act, of approbation, regard, confidence, civility, or admiration; a flattering speech or attention; a ceremonious greeting; as, to send one's compliments to a friend.
v. t.
To compliment.