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Segment of nucleic acid that affects the expression of associated genes
A regulatory sequence is a segment of a nucleic acid molecule which is capable of increasing or decreasing the expression of specific genes within an
Regulatory_sequence
Sequence of DNA that determines traits in an organism
intermediate template for the synthesis of a protein. Genes and their regulatory sequences are mainly responsible for determining the physical traits, or the
Gene
DNA sequence that binds activators to increase the likelihood of gene transcription
strategies have led to a better understanding of the features of regulatory DNA sequences, the prediction, and the design of synthetic enhancers. Building
Enhancer_(genetics)
the insulin transcription start site, called the "insulin regulatory sequence". This sequence is made up of several distinct regions with different biochemical
Insulin_regulatory_sequence
All genetic material of an organism
non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of junk DNA
Genome
Organisation of elements within a gene
functional. This includes the sequence that actually encodes the functional protein or ncRNA, as well as multiple regulatory sequence regions. These regions
Gene_structure
Group of open reading frames under the same regulation
important in its function is a regulatory gene, a constantly expressed gene which codes for repressor proteins. The regulatory gene does not need to be in
Operon
Region of non-coding DNA that regulates the transcription of neighboring genes
Both of these sequence elements are structural regions of DNA that serve as transcriptional regulators.[citation needed] Cis-regulatory modules are one
Cis-regulatory_element
DNA that does not code for proteins
piRNA, ribosomal RNA, and regulatory RNAs). Other functional regions of the non-coding DNA fraction include regulatory sequences that control gene expression;
Non-coding_DNA
Protein that increases transcription of a gene or set of genes
"activation domain". Most activators function by binding sequence-specifically to a regulatory DNA site located near a promoter and making protein–protein
Activator_(genetics)
RNA processing within a biological cell
produced by transcription often contains both exons (coding sequences) and introns (non-coding sequences); splicing removes the introns and links the exons directly
Post-transcriptional modification
Post-transcriptional_modification
Gene involved in controlling expression of other genes
regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. Regulatory sequences, which encode regulatory genes
Regulator_gene
DNA segment
cassette is a distinct component of vector DNA consisting of a gene and regulatory sequence to be expressed by a transfected cell. In each successful transformation
Expression_cassette
Cats with genetic anomaly that causes extra toes
of its paws. A point mutation in the noncoding region of the ZRS regulatory sequence causes abnormal SHH expression during limb development, causing variable
Polydactyl_cat
Complete set of nucleic acid sequences for humans
genome might be devoted to regulatory sequences. A value of 8% would correspond to approximately 10,000 bp of regulatory DNA per gene and a value of
Human_genome
Portion of gene's sequence which codes for protein
can be controlled by a regulatory sequence found before the open reading frame begins in a strand of DNA. The regulatory sequence will then determine the
Coding_region
DNA sequence
non-coding sequences are functional elements of the genome other than coding DNA. Some of these functional elements include non-coding genes, regulatory sequences
Conserved_non-coding_sequence
Process of copying a segment of DNA into RNA
protein. The regulatory sequence before (upstream from) the coding sequence is called the five prime untranslated regions (5'UTR); the sequence after (downstream
Transcription_(biology)
Faculty of mind to store and retrieve data
are not immediately repaired. About 600 regulatory sequences in promoters and about 800 regulatory sequences in enhancers appear to depend on double strand
Memory
Topics referred to by the same term
amplitude of an optical signal. Attenuator (genetics), a specific regulatory sequence transcribed into RNA. Impact attenuator, used on highways as a crumple
Attenuator
An upstream activating sequence or upstream activation sequence (UAS) is a cis-acting regulatory sequence found in yeast like Saccharomyces cerevisiae
Upstream_activating_sequence
Control of DNA to RNA conversion in cells
of activators or repressors. In the absence of other regulatory elements, a promoter's sequence-based affinity for RNA polymerases varies, which results
Transcriptional_regulation
transcription initiation without a functional TATA box. It has the consensus sequence YYA+1NWYY in humans. Similarly to the TATA box, the Inr element facilitates
Initiator_element
Topics referred to by the same term
protein component of proteasome-mediated protein degradation E2 regulatory sequence, for the insulin gene Levuglandin E2, an aldehyde Prostaglandin E2
E2
Technique in molecular biology
cellular processes in real-time. Reporter genes are often fused to regulatory sequences of genes of interest, enabling scientists to analyze promoter activity
Reporter_gene
DNA sequences with no known biological function
coding regions such as genes for ribosomal RNA and transfer RNA, regulatory sequences, origins of replication, centromeres, telomeres, and scaffold attachment
Junk_DNA
DNA sequence required in bacterial promoters for transcription
The Pribnow box (also known as the Pribnow-Schaller box) is a sequence of TATAAT of six nucleotides (thymine, adenine, thymine, etc.) that is an essential
Pribnow_box
Region of DNA encouraging transcription
conformation of regulatory proteins in a cell, which enable activating transcription factors to recruit RNA polymerase. Given the short sequences of most promoter
Promoter_(genetics)
American mathematician
for two mutations, studied the limits of Darwinian evolution in regulatory sequence evolution. Durrett's later research has applied branching processes
Rick_Durrett
DNA sequence
which has a shorter consensus sequence. The TATA box is considered a non-coding DNA sequence (also known as a cis-regulatory element). It was termed the
TATA_box
Biological mechanism
super-enhancer, located downstream the more distal Calpha gene, the 3' regulatory region (3'RR). In some occasions, the 3'RR super-enhancer can itself be
Immunoglobulin class switching
Immunoglobulin_class_switching
Gene or genetic material that has been transferred from one organism to another
promoter, which is a regulatory sequence that will determine where and when the transgene is active, an exon, a protein coding sequence (usually derived from
Transgene
gene starts in microbial genomes. Implications for finding sequence motifs in regulatory regions". Nucleic Acids Research. 29 (12): 2607–18. doi:10.1093/nar/29
List of gene prediction software
List_of_gene_prediction_software
Class of proteins involved in regulation of transcription
domain that binds either to a DNA promoter site or a specific DNA regulatory sequence called an enhancer. Binding of the activator-coactivator complex
Coactivator_(genetics)
consensus sequence was originally thought to be RGWCGTG, however more recent studies have suggested it to be the similar but more general sequence RGWYV(T)
Downstream_promoter_element
Topics referred to by the same term
public national television channel also known as Thalitha TV A3 regulatory sequence, a sequence for the insulin gene Adenosine A3 receptor, a human gene Annexin
A3
Protein found in humans
factors that have been predicted by Genomatix that binds to the regulatory sequence of the CCDC138 gene. CCDC138 has been identified as one of the many
CCDC138
Distinct pattern of nucleotides in molecular biology
binding general transcription factors. Both of these consensus sequences belong to the regulatory promoter. Full gene expression occurs when transcription activator
CAAT_box
Topics referred to by the same term
three-dimensional space group number 5 C2 domain, a protein structural domain C2 regulatory sequence for the insulin gene Apolipoprotein C2, a human apolipoprotein In
C2
Most common variant of a genetic sequence across samples
Specific sequence motifs can function as regulatory sequences controlling biosynthesis, or as signal sequences that direct a molecule to a specific site
Consensus_sequence
DNA response element in some eukaryotes
but distinct elements to bind E-box and tetraplex structures of regulatory sequences of muscle-specific genes". Nucleic Acids Res. 35 (21): 7087–7095
E-box
Chinese fluffy breed of chicken
single-nucleotide polymorphism in the regulator of the SHH gene, called the ZPA regulatory sequence. This causes ectopic SHH expression in the anterior of the developing
Silkie_(chicken_breed)
State of having more than five digits in ancient fish and tetrapods
of polarizing region activity regulatory sequence) that is located approximately 1 Mb upstream of the coding sequence of Shh." Devonian taxa were polydactylous
Polydactyly_in_stem-tetrapods
(BRE) is a DNA sequence found in the promoter region of most[clarification needed] genes in eukaryotes and Archaea. The BRE is a cis-regulatory element that
B_recognition_element
RNA family
(nuclear factor of activated T cells) Predicted secondary structure and sequence conservation of NRON Identifiers Symbol NRON Rfam RF00636 Other data RNA
NRON
Polygenic phenotypic characteristic
counts, hair and skin tone. The polymorphisms may be in an OCA2 regulatory sequence, where they may influence the expression of the gene product, which
Eye_color
gene-expression regulatory sequences (promoter and poly-A addition site sequences) also could have originated from stop codons. A conserved sequence, AATAAA,
Split_gene_theory
Functionless relative of a gene
Pseudogenes are usually identified when genome sequence analysis finds gene-like sequences that lack regulatory sequences or are incapable of producing a functional
Pseudogene
Topics referred to by the same term
A5 and variants may refer to: A5 regulatory sequence in biochemistry Androgen Androstenediol (abbreviation "A5") Annexin A5, a human cellular protein
A5
Topics referred to by the same term
later named Gobioolithus minor G1 phase, in the cellular cycle G1 regulatory sequence for the insulin gene Ganesha (psychedelic) (also known as G-1 or
G1
Conserved RNA structure
specific lineage of Actinomycetota. aspS motif RNAs likely function as cis-regulatory elements, in view of their positions upstream of protein-coding genes
AspS_RNA_motif
Conversion of a gene's sequence into a mature gene product or products
untranslated regions (3′UTRs) of messenger RNAs (mRNAs) often contain regulatory sequences that post-transcriptionally influence gene expression. Such 3′-UTRs
Gene_expression
Protein that exhibits bright green fluorescence when exposed to ultraviolet light
proteins and that is controlled by the same regulatory sequence; that is, the gene's regulatory sequence now controls the production of GFP, in addition
Green_fluorescent_protein
Collection of molecular regulators
A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell
Gene_regulatory_network
Protein-coding gene in the species Homo sapiens
protein encoded by SON gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human
SON_(gene)
Belgian bio-engineer and computational biologist
(2005-07-01). "TOUCAN 2: the all-inclusive open source workbench for regulatory sequence analysis". Nucleic Acids Research. 33 (Web Server issue): W393–396
Stein_Aerts
Protein-coding gene in the species Homo sapiens
has three paralogs in Homo sapiens: FAM46A, FAM46C, and FAM46D. Multiple sequence alignments of the four members of the FAM46 show high levels of conservation
Protein_FAM46B
Cellular process of protein synthesis
mRNAs can have different translation rates due to the presence of regulatory sequence elements. This has been shown to be important in a variety of settings
Translation_(biology)
Type of machine learning model
nature. Nucleic acid models have proven useful in detecting regulatory sequences, sequence classification, RNA-RNA interaction prediction, and RNA structure
Large_language_model
Development of limbs in vertebrates
enhancer sequences may have contributed to the progressive limb loss in snake evolution. In particular, many studies have focused on the ZPA Regulatory Sequence
Limb_development
Medical condition
Primarily, mutations are found in the zone of polarizing activity regulatory sequence, or ZRS, that controls the expression of SHH in developing limbs
Polysyndactyly
Alteration in the nucleotide sequence of a genome
is in a coding or non-coding region. Mutations in the non-coding regulatory sequences of a gene, such as promoters, enhancers, and silencers, can alter
Mutation
Heritable characteristics affecting learning
are not immediately repaired. About 600 regulatory sequences in promoters and about 800 regulatory sequences in enhancers appear to depend on double strand
Epigenetics in learning and memory
Epigenetics_in_learning_and_memory
Ability of an organism to exert itself and remain active for a long period of time
regulated, as in tissues generally, by regulatory DNA sequences, especially enhancers. Enhancers are non-coding sequences in the genome that activate the expression
Endurance
Field of molecular biology
constructs of candidate cis-regulatory elements is generated, each of these elements is linked to a unique barcode sequence and then cloned into plasmids
Functional_genomics
Topics referred to by the same term
Geb Čeb, old name for Čelarevo, Serbia CAAT enhancer binding, a regulatory sequence in DNA Census Enumerators' Books, books used by researchers in social
CEB
Topics referred to by the same term
reaction, which targets a protein for degradation via a proteasome] E1 regulatory sequence for the insulin gene Estrone, a hormone Pyruvate dehydrogenase (E1)
E1
Topics referred to by the same term
protein domain C1-inhibitor, a human serine protease inhibitor C1 regulatory sequence for the insulin gene Apolipoprotein C1, a human lipoprotein Chlorophyll
C1
Hypothesis for alleles
(not necessarily disease-causing) are known to exist in coding and regulatory sequences of genes. According to the CD-CV hypothesis, some of those variants
Common_disease-common_variant
Area of genome devoid of protein-coding genes
elements, including regulatory sequences, but also large stretches of junk DNA (See Non-coding DNA). One study focused on a regulatory archipelago, a region
Gene_desert
Biological cell regulation mechanisms
certain sequences.[citation needed] Three prime untranslated regions (3'-UTRs) of messenger RNAs (mRNAs) often contain regulatory sequences that post-transcriptionally
Regulation_of_gene_expression
a regulatory sequence that showed evidence of hominid adaptation, such as higher nucleotide substitution rates and certain regulatory sequences that
Contribution of epigenetic modifications to evolution
Contribution_of_epigenetic_modifications_to_evolution
White blood cells of the immune system
The regulatory T cells (Tregs /ˈtiːrɛɡ/ or Treg cells), formerly known as suppressor T cells, are a subpopulation of T cells that modulate the immune system
Regulatory_T_cell
Studies of the visible part of a canine
study found a regulatory sequence next to the gene Insulin-like growth factor 1 (IGF1), which, together with the gene and regulatory sequence, "is a major
Dog_anatomy
Nucleotide or amino-acid sequence pattern
the "B-form" DNA double helix). Outside of gene exons, there exist regulatory sequence motifs and motifs within the "junk", such as satellite DNA. Some
Sequence_motif
Group of transposable elements
"Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element". Human Molecular Genetics
LINE1
Transcription is heterocatalytic function of DNA
promoter. Well-characterized regulatory elements include enhancers, silencers, and insulators. These regulatory sequences can be spread over a large genomic
Eukaryotic_transcription
ORegAnno contained 4220 regulatory sequences (excluding deprecated records) for 2190 transcription factor binding sites, 1853 regulatory regions (enhancers
Open Regulatory Annotation Database
Open_Regulatory_Annotation_Database
RNA that is read by the ribosome to produce a protein
composing a final complex protein) and their coding sequence is grouped and regulated together in a regulatory region, containing a promoter and an operator
Messenger_RNA
Protein found in humans
nucleotides between the edited nucleoside and this mooring sequence. There is also a regulatory sequence 3′ to the editing site. The active site of ApoBEC-1
Apolipoprotein_B
Virus or plasmid designed for gene expression in cells
the production of proteins. The vector is engineered to contain regulatory sequences that act as enhancer and promoter regions and lead to efficient transcription
Expression_vector
Protein-coding gene in the species Homo sapiens
Betaglobin. Transcription factors of interest predicted to bind to the regulatory sequence include p53 tumor suppressors, SRY testis determining factors, Y-box
C18orf63
Protein that regulates the rate of DNA transcription
may be classified by their (1) mechanism of action, (2) regulatory function, or (3) sequence homology (and hence structural similarity) in their DNA-binding
Transcription_factor
Negative regulation (or limiting) of body weight and cell proliferation
currently being tested on mice. A plasmid composed of the H19 gene regulatory sequences that drive the expression of the 'A' strand of Diphtheria Toxin (DT-A)
H19_(gene)
In genetics, a stretch of DNA sequences located between genes
Intergenic regions may contain a number of functional DNA sequences such as promoters and regulatory elements, enhancers, spacers, and (in eukaryotes) centromeres
Intergenic_region
DNA Sequence
Posttranscriptional Regulatory Element (WPRE) is a DNA sequence that, when transcribed, creates a tertiary structure enhancing expression. The sequence is commonly
WHP Posttranscriptional Response Element
WHP_Posttranscriptional_Response_Element
Computational analysis of large, complex sets of biological data
determine genes that encode proteins, RNA genes, regulatory sequences, structural motifs, and repetitive sequences. A comparison of genes within a species or
Bioinformatics
codon and a stop codon. operator A regulatory sequence within an operon, typically located between the promoter sequence and the structural genes of the
Glossary of cellular and molecular biology (M–Z)
Glossary_of_cellular_and_molecular_biology_(M–Z)
Database
from GO. The nucleotide sequences of the promoter and coding regions for Yeast genes were obtained from Regulatory Sequence Analysis Tools (RSAT). All
Yeastract
Trans-regulatory elements (TRE) are DNA sequences encoding upstream regulators (ie. trans-acting factors), which may modify or regulate the expression
Trans-regulatory_element
Shadow enhancers are groups of DNA regulatory sequences that function alongside primary enhancers to regulate gene expression. Originally discovered in
Shadow_enhancer
Medical condition
Wilkie, Andrew O. M. (2008-08-15). "A variant in the sonic hedgehog regulatory sequence (ZRS) is associated with triphalangeal thumb and deregulates expression
Familial opposable triphalangeal thumbs duplication
Familial_opposable_triphalangeal_thumbs_duplication
these IEG genes. Activation of more than 600 regulatory sequences in promoters and 800 regulatory sequences in enhancers, in many cell types, appears to
TOP2B
Protein found in humans
Myosin regulatory light chain 11 is a protein that in humans is encoded by the MYL11 gene (previously MYLPF). Based on research on an ortholog in zebrafish
Myosin regulatory light chain 11
Myosin_regulatory_light_chain_11
Biological term
inter-individual differences in DNA methylation are mainly determined by cis-regulatory sequence polymorphisms, probably involving mutations in TFBSs (Transcription
Epigenome
One of the five main histone proteins
diversification among the regulatory genes. The greatest differences were observed in core histone gene cis-regulatory sequence motifs and associated protein
Histone_H2A
Species of flowering plant
alkaloid gene clusters across fungal endophytes: predicting the co-regulatory sequence motifs and the evolutionary history". Fungal Genetics and Biology
Lolium_arundinaceum
Small domesticated bird
larger leg bones. The cause of these changes is a change in the regulatory sequences of DNA that control the expression of the Pitx1 and the Tbx5 genes
Domestic_pigeon
Shared ancestry between DNA, RNA or protein sequences
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of
Sequence_homology
Subtype of DNA
molecular sponging. Transcription factors often bind to promoter or regulatory sequences at the 5' end of DNA to initiate transcription. These transcription
MicroDNA
travel, tourism, insurance
REGULATORY SEQUENCE
REGULATORY SEQUENCE
Boy/Male
Indian, Sanskrit
Connector; Regulator
Surname or Lastname
English
English : from a medieval male personal name (from Latin Hilarius, a derivative of hilaris ‘cheerful’, ‘glad’, from Greek hilaros ‘propitious’, ‘joyful’). The Latin name was chosen by many early Christians to express their joy and hope of salvation, and was borne by several saints, including a 4th-century bishop of Poitiers noted for his vigorous resistance to the Arian heresy, and a 5th-century bishop of Arles. Largely due to veneration of the first of these, the name became popular in France in the forms Hilari and Hilaire, and was brought to England by the Norman conquerors.English : from the much rarer female personal name Eulalie (from Latin Eulalia, from Greek eulalos ‘eloquent’, literally well-speaking, chosen by early Christians as a reference to the gift of tongues), likewise introduced into England by the Normans. A St. Eulalia was crucified at Barcelona in the reign of the Emperor Diocletian and became the patron of that city. In England the name underwent dissimilation of the sequence -l-l- to -l-r- and the unfamiliar initial vowel was also mutilated, so that eventually the name was considered as no more than a feminine form of Hilary (of which the initial aspirate was in any case variable).
Boy/Male
Indian, Sikh
Music; In-sequence
Girl/Female
Tamil
Anuloma | அநà¯à®²à¯‹à®®à®¾
Sequence
Anuloma | அநà¯à®²à¯‹à®®à®¾
Boy/Male
Indian, Sanskrit
Order; Sequence
Girl/Female
Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Telugu
Sequence
REGULATORY SEQUENCE
REGULATORY SEQUENCE
REGULATORY SEQUENCE
REGULATORY SEQUENCE
REGULATORY SEQUENCE
REGULATORY SEQUENCE
REGULATORY SEQUENCE
travel, tourism, insurance