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Type of RNA molecules
Ribozymes (ribonucleic acid enzymes) are RNA molecules that have the ability to catalyze specific biochemical reactions, including RNA splicing in gene
Ribozyme
The RNA Ligase ribozyme was the first of several types of synthetic ribozymes produced by in vitro evolution and selection techniques. They are an important
Ligase_ribozyme
RNA family
The hammerhead ribozyme is an RNA motif that catalyzes reversible cleavage and ligation reactions at a specific site within an RNA molecule. It is one
Hammerhead_ribozyme
American biochemist and Nobel laureate (born 1964)
the 2000 Alan T. Waterman Award for her research on the structure of a ribozyme, as determined by X-ray crystallography and the 2015 Breakthrough Prize
Jennifer_Doudna
RNA structure that catalyzes its own cleavage at a specific site
ribozyme is an RNA structure that catalyzes its own cleavage at a specific site. In other words, it is a self-cleaving ribozyme. The pistol ribozyme was
Pistol_ribozyme
Enzymatic section of RNA
The hairpin ribozyme is a small section of RNA that can act as a ribozyme. Like the hammerhead ribozyme it is found in RNA satellites of plant viruses
Hairpin_ribozyme
RNA structure
twister sister ribozyme (TS) is an RNA structure that catalyzes its own cleavage at a specific site. In other words, it is a self-cleaving ribozyme. The twister
Twister_sister_ribozyme
Hypothetical stage in the early evolutionary history of life on Earth
(ribozymes) can catalyze (start or accelerate) chemical reactions that are critical for life, so it is conceivable that in an RNA world, ribozymes might
RNA_world
Family of large biological molecules
with the notable and important exception of the ribosome, which is a ribozyme. Each nucleotide in RNA contains a ribose sugar, with carbons numbered
RNA
RNA family
Lariat capping ribozyme (formerly called GIR1 branching ribozyme) is a ~180 nt ribozyme with an apparent resemblance to a group I ribozyme. It is found
GIR1_branching_ribozyme
Non-coding RNA in hepatitis delta virus
The hepatitis delta virus (HDV) ribozyme is a non-coding RNA found in the hepatitis delta virus that is necessary for viral replication. Hepatitis delta
Hepatitis delta virus ribozyme
Hepatitis_delta_virus_ribozyme
Varkud satellite (VS) ribozyme is an RNA enzyme that carries out the cleavage of a phosphodiester bond. Varkud satellite (VS) ribozyme is the largest known
VS_ribozyme
Ribozyme capable of self-cleavage
The twister ribozyme is a catalytic RNA structure capable of self-cleavage. The nucleolytic activity of this ribozyme has been demonstrated both in vivo
Twister_ribozyme
Ribozyme
The mammalian CPEB3 ribozyme is a self cleaving non-coding RNA located in the second intron of the CPEB3 gene which belongs to a family of genes regulating
Mammalian_CPEB3_ribozyme
Self-cleaving ribozyme
Hatchet ribozyme is an RNA structure that catalyzes its own cleavage at a specific site. In other words, it is a self-cleaving ribozyme. Hatchet ribozymes were
Hatchet_ribozyme
Cyclic sequence of self-reproducing single cycles
quasispecies 1982 (1982): Discovery of ribozyme catalytic properties 2001 (2001): Partial RNA polymerase ribozyme is designed via directed evolution 2012 (2012):
Hypercycle_(chemistry)
Class of enzymes
which cleaves RNA. RNase P is unique from other RNases in that it is a ribozyme – a ribonucleic acid that acts as a catalyst in the same way that a protein-based
Ribonuclease_P
Manganese dependent RNA enzyme
The Vg1 ribozyme is a manganese dependent RNA enzyme or ribozyme which is the smallest ribozyme to be identified. It was identified in the 3′ UTR of Xenopus
Vg1_ribozyme
History of Earth 4600–539 million years ago
porous rock systems comprising heated air-water interfaces could allow ribozyme-catalyzed RNA replication of sense and antisense strands that could be
Precambrian
Protein that contains a metal ion cofactor
of ribozymes by Thomas Cech and Sidney Altman in the early 1980s, ribozymes have been shown to be a distinct class of metalloenzymes. Many ribozymes require
Metalloprotein
Geologic eon, 4567–4031 million years ago
rock systems comprising heated air-water interfaces were shown to allow ribozyme-catalyzed RNA replication of sense and antisense strands followed by subsequent
Hadean
Process that prevents the expression of a gene
group II ribozymes. These motifs can self-splice by cleaving and joining phosphodiester bonds. The last ribozyme motif, the RNase P ribozyme, is found
Gene_silencing
Circular single-stranded RNA(s) dependent on viruses for replication
possess a protein coat. Both virusoids and a few viroids encode a hammerhead ribozyme. Virusoids, while being studied in virology, are subviral particles rather
Virusoid
Synthetic DNA analog experiment
laboratory." The hachimoji DNA system produced one type of catalytic RNA (ribozyme or aptamer) in vitro. NASA funded this research to "expand[s] the scope
Artificially Expanded Genetic Information System
Artificially_Expanded_Genetic_Information_System
Reaction that cleaves the RNA molecule
Examples of such ribozymes include the hammerhead ribozyme, the Hepatitis Delta Virus (HDV) ribozyme, and the hairpin ribozyme. Large ribozymes, such as Group
RNA_hydrolysis
Biological kingdom
transcriptase Reverse transcriptase-related cellular gene Retrosequence Ribozyme Spiegelman's Monster shorter form Tandem repeat Transposable element Transpoviron
Animal
Pathogenic small single-stranded circular RNA
synthesis of new RNA using the viroid's RNA as a template. Viroids are often ribozymes, having catalytic properties that allow self-cleavage and ligation of
Viroid
RNA family
nucleotides in length. The only known RNAs that are longer than OLE RNA are ribozymes such as the group II intron and ribosomal RNAs. The exceptional length
OLE_RNA
Interactions between nucleic acid modules
compared to protein oligomers. One example of an RNA homodimer is the VS ribozyme from Neurospora, with its two active sites consisting of nucleotides from
Nucleic acid quaternary structure
Nucleic_acid_quaternary_structure
Bioinformatics strategy
Twister and Hammerhead ribozymes (RAGATH) refers to a bioinformatics strategy that was devised to find self-cleaving ribozymes in bacteria. It also refers
RAGATH_RNA_motifs
Molecule that carries genetic information
both transmit genetic information and carry out catalysis as part of ribozymes. This ancient RNA world where nucleic acid would have been used for both
DNA
RNA family
Hovlinc RNA is a self-cleaving ribozyme of about 168 nucleotides found in a very long noncoding RNA (vlincRNA) in humans, chimpanzees, and gorillas. The
Hovlinc
Class of self-catalyzing ribozymes
class of self-catalytic ribozymes and mobile genetic elements found within the genes of all three domains of life. Ribozyme activity (e.g., self-splicing)
Group_II_intron
Large self-splicing ribozymes
Group I introns are large self-splicing ribozymes. They catalyze their own excision from mRNA, tRNA and rRNA precursors in a wide range of organisms.
Group_I_catalytic_intron
systems, comprising heated air-water interfaces, were shown to facilitate ribozyme catalyzed RNA replication of sense and antisense strands and then subsequent
Earliest_known_life_forms
Realm of viruses
animal viruses. Viruses in the realm are characterized by the presence of ribozymes in the genome that are involved in replication. They encode one protein
Ribozyviria
RNA family
The glucosamine-6-phosphate riboswitch ribozyme ( glmS ribozyme) is an RNA structure that resides in the 5' untranslated region (UTR) of the mRNA transcript
GlmS glucosamine-6-phosphate activated ribozyme
GlmS_glucosamine-6-phosphate_activated_ribozyme
Intramolecular base-pairing pattern in RNA and DNA
forms part of the second stem. Many ribozymes also feature stem-loop structures. The self-cleaving hammerhead ribozyme contains three stem-loops that meet
Stem-loop
Amino acid that is incorporated biosynthetically into proteins during translation
found to be related to the set of amino acids that can be recognized by ribozyme autoaminoacylation systems. Thus, non-proteinogenic amino acids would have
Proteinogenic_amino_acid
American biochemist
ribosomes in particular are catalysed by RNA. RNA enzymes are known as ribozymes and have provided a new tool for gene technology. They also have the potential
Thomas_Cech
Oldest cultured human cell line (1951)
transcriptase Reverse transcriptase-related cellular gene Retrosequence Ribozyme Spiegelman's Monster shorter form Tandem repeat Transposable element Transpoviron
HeLa
Family of retrotransposons
contain a hammerhead ribozyme (HHR) in their sequences (and so the name retrozyme is a combination of retrotransposon and hammerhead ribozyme), although they
Retrozyme
RNA component of the ribosome, essential for protein synthesis in all living organisms
the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries out protein synthesis in ribosomes. Ribosomal RNA is transcribed
Ribosomal_RNA
Medication used to treat a viral infection
ribozymes, which are RNA sequences with catalytic activity that will cut apart viral RNA or DNA at selected sites. In their natural course, ribozymes
Antiviral_drug
Basepairing interactions within a single nucleic acid polymer or between two polymers
pseudoknot that is critical for its activity. The hepatitis delta virus ribozyme is a well known example of a catalytic RNA with a pseudoknot in its active
Nucleic acid secondary structure
Nucleic_acid_secondary_structure
Phylum of RNA viruses
containing ribozymes in both sense and antisense orientations, similar to viroids—small, circular infectious agents that also utilize ribozymes. Ambiviruses
Ambiviricota
Composite of the organism's observable characteristics or traits
three-dimensional physical structure of the first RNA molecule that possessed ribozyme activity promoting replication while avoiding destruction would have been
Phenotype
RNA family
self-cleaving ribozyme that forms at the 5' junction of the R2 RNA. This ribozyme has been found to have high structural similarity to the HDV ribozyme but they
R2_RNA_element
Protein-coding gene in the species Homo sapiens
Doudna JA (October 1998). "Crystal structure of a hepatitis delta virus ribozyme". Nature. 395 (6702): 567–74. Bibcode:1998Natur.395..567F. doi:10.1038/26912
Small nuclear ribonucleoprotein polypeptide A
Small_nuclear_ribonucleoprotein_polypeptide_A
Ribosomal component
peptidyl transferase center (EC 2.3.2.12, PTC) is an aminoacyltransferase ribozyme (RNA enzyme) located in the large subunit of the ribosome. It forms peptide
Peptidyl_transferase_center
Hypothesis about the origin of life
The RNA world hypothesis shows how RNA can become its own catalyst (a ribozyme). In between there are some missing steps such as how the first RNA molecules
PAH_world_hypothesis
Type of drug
Angiozyme is an anti-angiogenic ribozyme. It is largely being studied in the treatment of kidney cancer. It may prevent the growth of blood vessels from
Angiozyme
Theoretical limit on rate of mutation
postulated that the first self-replicating molecules might have been small ribozyme-like RNA molecules. These molecules consist of strings of base pairs or
Error_threshold_(evolution)
Theory that viruses predate cellular life
from an early RNA world to the modern DNA/protein world. Viroids and ribozymes, as the simplest known self-replicating RNA elements, could be considered
Virus_world_hypothesis
Process of increasing the rate of a chemical reaction
nonprotein-based classes of biomolecules also exhibit catalytic properties including ribozymes, and synthetic deoxyribozymes. Biocatalysts can be thought of as an intermediate
Catalysis
One of the two major RNA components of the ribosome
LSU rRNA forms the large subunit of the ribosome. The LSU rRNA acts as a ribozyme, catalyzing peptide bond formation. LSU rRNA sequences are widely used
LSU_rRNA
American public research university
Retrieved November 14, 2006. Jackman, Jane E. (April 2015). "An origin story: ribozyme catalysis by the ribosome". RNA. 21 (4): 650–651. doi:10.1261/rna.050328
University of Colorado Boulder
University_of_Colorado_Boulder
Molecule produced by a living organism
single-stranded loops, bulges, and junctions. Examples are tRNA, ribosomes, ribozymes, and riboswitches. These complex structures are facilitated by the fact
Biomolecule
Domain of life whose cells have nuclei
transcriptase Reverse transcriptase-related cellular gene Retrosequence Ribozyme Spiegelman's Monster shorter form Tandem repeat Transposable element Transpoviron
Eukaryote
Domain of microorganisms
transcriptase Reverse transcriptase-related cellular gene Retrosequence Ribozyme Spiegelman's Monster shorter form Tandem repeat Transposable element Transpoviron
Bacteria
Japanese chemist (born 1963)
biochemist and businessman. He is best known for his work on artificial ribozymes (flexizymes) and their application in mRNA display (RaPID, random nonstandard
Hiroaki_Suga
Study of biochemical reaction rates catalysed by an enzyme
as ribozymes and ribosomes are essential to many cellular functions, such as RNA splicing and translation. The main difference between ribozymes and
Enzyme_kinetics
Records of Earth's development
and self-replication. The discovery that a kind of RNA molecule called a ribozyme can catalyze both its own replication and the construction of proteins
History_of_Earth
1980s, including the hammerhead ribozyme. In 1994, McKay et al. published the structure of a 'hammerhead RNA-DNA ribozyme-inhibitor complex' at 2.6 Ångström
History_of_molecular_biology
Macromolecular machine that synthesizes proteins in cells
usually broken up but can be reused. Ribosomes are a kind of enzyme, called ribozymes because the catalytic peptidyl transferase activity that links amino acids
Ribosome
support for the "inside-out" model of planet formation. A small polymerase ribozyme is described which can synthesize both its complementary strand and a copy
2026_in_science
Succession of nucleotides in a nucleic acid
tertiary, and quaternary) using DNA helices and examples from the VS ribozyme and telomerase and nucleosome. (PDB: ADNA, 1BNA, 4OCB, 4R4V, 1YMO, 1EQZ)
Nucleic_acid_sequence
Realm of viruses
transcriptase Reverse transcriptase-related cellular gene Retrosequence Ribozyme Spiegelman's Monster shorter form Tandem repeat Transposable element Transpoviron
Singelaviria
Swiss molecular biologist
previously discovered ribozyme with RNA polymerase activity, Holliger and colleagues initially engineered an RNA polymerase ribozyme capable of synthesising
Philipp_Holliger
Infectious agent that replicates in cells
transcriptase Reverse transcriptase-related cellular gene Retrosequence Ribozyme Spiegelman's Monster shorter form Tandem repeat Transposable element Transpoviron
Virus
Lipid globule proposed as a precursor of living cells
contained system consisting of simple biologically relevant molecules like ribozymes, and encapsulated in a simple membrane structure – isolating the entity
Protocell
Ancestor of all current life on Earth
transcriptase Reverse transcriptase-related cellular gene Retrosequence Ribozyme Spiegelman's Monster shorter form Tandem repeat Transposable element Transpoviron
Last universal common ancestor
Last_universal_common_ancestor
Pathogenic type of misfolded protein
transcriptase Reverse transcriptase-related cellular gene Retrosequence Ribozyme Spiegelman's Monster shorter form Tandem repeat Transposable element Transpoviron
Prion
Biological process
Abiogenesis Last universal common ancestor Earliest known life forms ?RNA life Ribozyme †Protocell Coacervate Proteinoid Sulphobe Research Model lipid bilayer
Cell_division
Process in molecular biology
ribonucleoproteins (snRNPs). There exist self-splicing introns, that is, ribozymes that can catalyze their own excision from their parent RNA molecule. The
RNA_splicing
Mobile genetic elements
transcriptase Reverse transcriptase-related cellular gene Retrosequence Ribozyme Spiegelman's Monster shorter form Tandem repeat Transposable element Transpoviron
Integrative and conjugative element
Integrative_and_conjugative_element
RNA family
The Beta-globin co-transcriptional cleavage ribozyme (CotC ribozyme) was a proposed ribozyme (short for ribonucleic acid enzyme). Transcription termination
Beta-globin co-transcriptional cleavage ribozyme
Beta-globin_co-transcriptional_cleavage_ribozyme
DNA oligonucleotides that can perform a specific chemical reaction
similar to the action of other biological enzymes, such as proteins or ribozymes (enzymes composed of RNA). However, in contrast to the abundance of protein
Deoxyribozyme
Biological process
Abiogenesis Last universal common ancestor Earliest known life forms ?RNA life Ribozyme †Protocell Coacervate Proteinoid Sulphobe Research Model lipid bilayer
DNA_replication
Realm of viruses
genomes. Their genomes contain at least two open reading frames (ORFs) and ribozymes in opposite sense orientations of the genome—one positive-sense portion
Riboviria
Evolutionary origin and subsequent development of cells
filled by RNA, and catalysis was also largely mediated by RNA (that is, by ribozyme counterparts of enzymes). This concept is known as the RNA world hypothesis
Evolution_of_cells
Rules by which information encoded within genetic material is translated into proteins
early tRNA-like ribozymes may have had different affinities for amino acids, with codons emerging from another part of the ribozyme that exhibited random
Genetic_code
Life that has no cellular structure
synthesis of new RNA using the viroid's RNA as a template. Some viroids are ribozymes, having catalytic properties which allow self-cleavage and ligation of
Non-cellular_life
Process of copying a segment of DNA into RNA
Abiogenesis Last universal common ancestor Earliest known life forms ?RNA life Ribozyme †Protocell Coacervate Proteinoid Sulphobe Research Model lipid bilayer
Transcription_(biology)
Type of DNA molecule
synthesis was initiated between genes C and A). They are further broken by ribozymes. During active infection, some species of viruses have been shown to replicate
Concatemer
RNA that facilitates the addition of amino acids to a new protein
tRNA-like aggregates have an important catalytic influence (i.e., as ribozymes) on replication still today. These roles may be regarded as 'molecular
Transfer_RNA
Biochemist (born 1961)
structure of the full length Azoarcus Group I catalytic intron, the glmS ribozyme, and the c-di-GMP riboswitch. He has also collaborated with the Thomas
Scott_Strobel
DNA that does not code for proteins
Abiogenesis Last universal common ancestor Earliest known life forms ?RNA life Ribozyme †Protocell Coacervate Proteinoid Sulphobe Research Model lipid bilayer
Non-coding_DNA
Indian–American biochemist
folding and biological catalysis through investigations with the Tetrahymena ribozyme (Thesis). OCLC 84444091. "Geeta Narlikar". IIT Bay Area Alumni. Retrieved
Geeta_Narlikar
Family of viroids
cleaved by ribozyme activity and circularises. A second rolling circle mechanism forms a positive strand which is also cleaved by ribozyme activity and
Avsunviroidae
enzyme. Examples would be the cleaved bond in the self-cleaving hammerhead ribozyme or the peptide bond of a substrate cleaved by a peptidase. Murray JB, Scott
Scissile_bond
List of microorganisms
to consider other self-replicating genetic elements, such as obelisks, ribozymes, satelliviruses and viroids.[citation needed] Several species of Myxozoa
Smallest_organisms
Organism belonging to kingdom Fungi
transcriptase Reverse transcriptase-related cellular gene Retrosequence Ribozyme Spiegelman's Monster shorter form Tandem repeat Transposable element Transpoviron
Fungus
DNA sequence that jumps/transposes within a genome
transcriptase Reverse transcriptase-related cellular gene Retrosequence Ribozyme Spiegelman's Monster shorter form Tandem repeat Transposable element Transpoviron
Transposable_element
Topics referred to by the same term
oldest limber pine (Pinus flexilis) near the Alta Ski Area in Utah Twister ribozyme, a catalytic RNA structure capable of self-cleavage Twister, an occupation
Twister
Small DNA molecule within a cell
transcriptase Reverse transcriptase-related cellular gene Retrosequence Ribozyme Spiegelman's Monster shorter form Tandem repeat Transposable element Transpoviron
Plasmid
Biological entity that causes disease in its host
a protein coat, and it does not encode any proteins, only acting as a ribozyme to catalyze other biochemical reactions. Viruses are generally between
Pathogen
Type of behavior of a dynamical system
Abiogenesis Last universal common ancestor Earliest known life forms ?RNA life Ribozyme †Protocell Coacervate Proteinoid Sulphobe Research Model lipid bilayer
Self-replication
Mechanism of evolution by differential reproduction
initially by the folded configurations (including those configurations with ribozyme activity) of the RNA replicators that, in turn, would have been encoded
Natural_selection
Unclassified/poorly understood genetics
transcriptase Reverse transcriptase-related cellular gene Retrosequence Ribozyme Spiegelman's Monster shorter form Tandem repeat Transposable element Transpoviron
Biological_dark_matter
RIBOZYME
RIBOZYME
RIBOZYME
RIBOZYME
Boy/Male
Tamil
Name of a demon
Boy/Male
Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Favourite of the Devotees; A Name for Lord Shiva
Boy/Male
Tamil
Surname or Lastname
English
English : habitational name from Parnham in Beaminster, Dorset.
Boy/Male
Norse
Fighter of the nest.
Girl/Female
Gujarati, Hindu, Indian, Kannada, Sanskrit, Tamil
Handsome
Female
Egyptian
, a queen of Nubia.
Girl/Female
Welsh
Bright sea.
Biblical
that blots out; that suppresses
Boy/Male
Hindu
Golden king
RIBOZYME
RIBOZYME
RIBOZYME
RIBOZYME
RIBOZYME