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Eosinophil major basic protein, often shortened to major basic protein (MBP; also called proteoglycan 2 (PRG2)) is encoded in humans by the PRG2 gene
Major_basic_protein
Protein family
Myelin basic protein (MBP) is a protein important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane
Myelin_basic_protein
Variety of white blood cells
ribonuclease (RNase), deoxyribonucleases (DNase), lipase, plasminogen, and major basic protein. These mediators are released by a process called degranulation following
Eosinophil
Class of enzymes
recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor". The
Pappalysin-1
Excess number of eosinophil cells in the blood
platelet activating factor), and toxic proteins (e.g. metalloproteinases, major basic protein, eosinophil cationic protein, eosinophil peroxidase, and eosinophil-derived
Eosinophilia
Topics referred to by the same term
1979 Mega base pairs (Mbp) Major basic protein, a protein which in humans is encoded by the PRG2 gene Maltose-binding protein, a part of the maltose/maltodextrin
MBP
Cell membrane engulfing a large particle
as lysozymes, Bactericidal permeability-increasing protein, Major basic protein and cationic proteins such as defensins. Other antimicrobial peptides are
Phagocytosis
Process by which cells lose secretory granules
mechanism, activated eosinophils release preformed mediators such as major basic protein, and enzymes such as peroxidase, following interaction between their
Degranulation
Protein family
Major capsid protein VP1 is a viral protein that is the main component of the polyomavirus capsid. VP1 monomers are generally around 350 amino acids long
Major_capsid_protein_VP1
Mammalian protein found in Homo sapiens
excess eosinophil-specific granule proteins (such as major basic protein, erythropoietin and eosinophil cationic protein) on the endothelial surface bind
Protein_C
the parasites and leads to eosinophil degranulation which releases major basic protein that damages the parasites, and other factors elicit a local inflammatory
Premunition
Protein domain
carbohydrate-binding protein known as a lectin. The C-type designation is from their requirement for calcium for binding. Proteins that contain C-type
C-type_lectin
Surface protein important to the immune system
eosinophils. Activated eosinophils release preformed mediators such as major basic protein, and enzymes such as peroxidase, against which helminths are not
Fc_receptor
Medical condition
damage caused by the damaging effects of eosinophil granule proteins (e.g. major basic protein) is known as Loeffler endocarditis and can be caused by idiopathic
Löffler's_syndrome
Mammalian protein found in Homo sapiens
cationic protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix. In humans, the eosinophil cationic protein is
Eosinophil_cationic_protein
Secretory vesicles within the immune system
phosphatase, lactoferrin, lysozyme, NADPH oxidase Eosinophil: cathepsin, major basic protein Basophil: heparin, histamine (not directly cytotoxic) A specific
Specific_granule
Biomolecule consisting of chains of amino acid residues
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions
Protein
Proteins that bind with DNA
involves DNA binding to a complex of small basic proteins called histones. In prokaryotes, multiple types of proteins are involved. The histones form a disk-shaped
DNA-binding_protein
The liver plays the major role in producing proteins that are secreted into the blood, including major plasma proteins, factors in hemostasis and fibrinolysis
Proteins produced and secreted by the liver
Proteins_produced_and_secreted_by_the_liver
degranulate releasing a number of cytotoxic molecules (including Major Basic Protein and eosinophil peroxidase) as well as produce a number of cytokines
Allergic_inflammation
Cell surface proteins, part of the acquired immune system
polymorphic genes that code for cell surface proteins essential for the adaptive immune system. These cell surface proteins are called MHC molecules. Its name comes
Major histocompatibility complex
Major_histocompatibility_complex
Medical condition
5-oxo-eicosatetraenoic acid), and toxic proteins (e.g. metalloproteinases, major basic protein, eosinophil cationic protein, eosinophil peroxidase, and eosinophil-derived
Eosinophilic_myocarditis
Medical condition
(e.g. elevated serum levels of eosinophil-derived neurotoxin and major basic protein), and increased expression of a marker for T cell activation, interleukin-2
Familial_eosinophilia
Protein family
Major intrinsic proteins comprise a large superfamily of transmembrane protein channels that are grouped together on the basis of homology. The MIP superfamily
Major_intrinsic_proteins
Protein-coding gene in the species Homo sapiens
redundancy in peroxidase-mediated immune mechanisms. Eosinophil Major basic protein Secretory pathway Peroxiredoxin Catalase Reactive oxygen species
Eosinophil_peroxidase
Overview of and topical guide to immunology
Granuloma Acute-phase proteins Amyloid SAP SAA Positive Alpha 1-antichymotrypsin Alpha 1-antitrypsin Alpha 2-macroglobulin C-reactive protein Ceruloplasmin C3
Outline_of_immunology
American chemist and computer scientist (born 1985)
the structure of a protein. In 2023 he was awarded the Canada Gairdner International Award and the Albert Lasker Award for Basic Medical Research. In
John_M._Jumper
Human protein and coding gene
Basic helix-loop-helix ARNT-like protein 1 or aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL), or brain and muscle ARNT-like 1 is
Basic helix-loop-helix ARNT-like protein 1
Basic_helix-loop-helix_ARNT-like_protein_1
Protein-coding gene in humans
isoforms regulate transcription of the gene encoding eosinophil granule major basic protein". The Journal of Biological Chemistry. 277 (45): 43481–94. doi:10
CEBPE
DNA-binding structural motif
structural motif in proteins. It was first described by Landschulz and collaborators in 1988 when they found that an enhancer binding protein had a very characteristic
Leucine_zipper
Protein structural motif
A basic helix–loop–helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors. The word
Basic_helix–loop–helix
Type of myelin-associated protein
expression may be regulated by MITF. Proteolipid protein 1 has been shown to interact with Myelin basic protein. PLP2 GRCh38: Ensembl release 89: ENSG00000123560
Proteolipid_protein_1
Pathogenic type of misfolded protein
Prions are primarily twisted isoforms of the major prion protein (PrP), a naturally occurring protein with an uncertain function. They are the hypothesized
Prion
Artificial intelligence program by DeepMind
and the Albert Lasker Award for Basic Medical Research in 2023 for their leadership of the AlphaFold project. Proteins consist of chains of amino acids
AlphaFold
Protein family
mediates protein degradation and recognition in E. coli. The basic recognition of proteins by AAAs is thought to occur through unfolded protein domains
AAA_proteins
Lipidation modification
myristoyl groups and "basic patches" (highly positive regions on the protein) characterize myristoyl-electrostatic switches. The basic patch allows for favorable
Myristoylation
that the sequence information encoded in the three major classes of biopolymer—DNA, RNA, and protein—can only be transferred between these three classes
Glossary of cellular and molecular biology (0–L)
Glossary_of_cellular_and_molecular_biology_(0–L)
Rational design of new protein molecules
Protein design is the rational design of new protein molecules to design novel activity, behavior, or purpose, and to advance basic understanding of protein
Protein_design
Diagram of optimal servings of basic foods
animals are edible, there is a vast variety of meats. Meat is a major source of protein, as well as iron, zinc, and vitamin B12. The category of meats
Food_pyramid_(nutrition)
Sequence of DNA that determines traits in an organism
types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of RNA or protein from a gene), DNA is first
Gene
Antifibrinolytic molecule
now Nordic Group pharmaceuticals), is a small protein bovine pancreatic trypsin inhibitor (BPTI), or basic trypsin inhibitor of bovine pancreas, which is
Aprotinin
Change of a linear protein chain to a 3D structure
Protein folding is the physical process by which a protein, after synthesis by a ribosome as a linear chain of amino acids, changes from an unstable random
Protein_folding
Protein spanning across a biological membrane
pass through it. There are two basic types of transmembrane proteins: alpha-helical and beta barrels. Alpha-helical proteins are present in the inner membranes
Transmembrane_protein
Class of proteins involved in inflammation
Acute-phase proteins (APPs) are a class of proteins whose concentrations in blood plasma either increase (positive acute-phase proteins) or decrease (negative
Acute-phase_protein
American medical science award
The award is given in four branches of medical science: Albert Lasker Basic Medical Research Award Lasker–DeBakey Clinical Medical Research Award Lasker–Bloomberg
Lasker_Award
Study of how proteins move and change shape
molecular biology, proteins are generally thought to adopt unique structures determined by their amino acid sequences. However, proteins are not strictly
Protein_dynamics
Class of compounds
Proteoglycans are proteins that are heavily glycosylated. The basic proteoglycan unit consists of a "core protein" with one or more covalently attached
Proteoglycan
Laboratory technique to separate ions and polar molecules
almost any kind of charged molecule—including small inorganic anions, large proteins, small nucleotides, and amino acids. However, ion chromatography must be
Ion_chromatography
Protein-coding gene in the species Homo sapiens
Myelin protein zero (MPZ), also Myelin protein P0, is a single membrane glycoprotein which in humans is encoded by the MPZ gene. P0 is a major structural
Myelin_protein_zero
Class of molecular proteins
Motor proteins are a class of molecular motors that can move along the cytoskeleton of cells. They do this by converting chemical energy into mechanical
Motor_protein
Protein family
signals using a conserved family of proteins called SMADs. They play fundamental roles in the regulation of basic biological processes such as growth
Transforming growth factor beta superfamily
Transforming_growth_factor_beta_superfamily
Family of DNA sequences found in prokaryotic organisms
according to the predicted function of their proteins. Experimental work by several groups revealed the basic mechanisms of CRISPR-Cas immunity. In 2007
CRISPR
Biological membrane that separates the interior of a cell from its outside environment
contains membrane proteins, including integral proteins that span the membrane and serve as transporters, and peripheral proteins that attach to the
Cell_membrane
Protein-coding gene in humans
(1976). "Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils". J. Clin. Invest. 57 (3): 633–40
CLC_(gene)
Protein-coding gene in the species Homo sapiens
N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene
N-Myc
Complex of DNA and protein in eukaryotic cells
therefore gene expression. The primary protein components of chromatin are histones. Nucleosome, the fundamental basic unit of chromatin, consists of DNA
Chromatin
Cytoskeletal structure
sequence and protein structure: These proteins are the most diverse among IFs and constitute type I (acidic) and type II (basic) IF proteins. The many isoforms
Intermediate_filament
Type III intermediate filament protein
fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans. It is a type III intermediate filament (IF) protein that is expressed
Glial fibrillary acidic protein
Glial_fibrillary_acidic_protein
Basic taste
Sweetness is a basic taste most commonly perceived when eating foods rich in sugar. Sweet tastes are generally regarded as pleasurable. In addition to
Sweetness
Major structure in coronaviruses
membrane (M) protein (previously called E1, sometimes also matrix protein) is an integral membrane protein that is the most abundant of the four major structural
Coronavirus_membrane_protein
Mood disorder
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low
Major_depressive_disorder
Amino acid that is incorporated biosynthetically into proteins during translation
incorporated biosynthetically into proteins during translation from RNA. The word "proteinogenic" means "protein creating". Throughout known life, there
Proteinogenic_amino_acid
Type of amino acid sequence
which targets proteins out of the nucleus. These types of NLSs can be further classified as either monopartite or bipartite. The major structural differences
Nuclear_localization_sequence
Family of globular proteins
by the immune system. Globulins, albumins, and fibrinogen are the major blood proteins. The normal concentration of globulins in human blood is about 2
Globulin
Glycoprotein spike on a viral capsid or viral envelope
called spike protein, formerly known as E2) is the largest of the four major structural proteins found in coronaviruses. The spike protein assembles into
Coronavirus_spike_protein
Protein family
(40–60% of the dry weight) and the major pain-producing substance of honeybee (Apis mellifera) venom. Melittin is a basic peptide consisting of 26 amino acids
Melittin
Type of diet
providing the body with essential nutrition: water, macronutrients such as protein, micronutrients such as vitamins, and adequate fibre and food energy. A
Healthy_diet
Amino acids required in diet since they can not be synthesized in body
"value" of various kinds of protein. Measures include the biological value, net protein utilization, protein efficiency ratio, protein digestibility corrected
Essential_amino_acid
Biological mechanism for routing proteins
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside
Protein_targeting
Bacteriophage that infects Escherichia coli
viruses. Life Cycle, Basic Animation of Lambda Lifecyecle (illustrates infection and lytic/lysogenic pathways with some protein and transcription detail)
Lambda_phage
Components of human immunodeficiency virus
protease, some minor proteins, and the major core protein. The genome of human immunodeficiency virus (HIV) encodes 8 viral proteins playing essential roles
Structure_and_genome_of_HIV
One of the five basic tastes
from Japanese: うま味, pronounced [ɯmami]), or savoriness, is one of the five basic tastes. It is characteristic of broths and cooked meats. People taste umami
Umami
Process by which a gene can code for multiple proteins
combinations, leading to different splice variants. In the case of protein-coding genes, the proteins translated from these splice variants may contain differences
Alternative_splicing
Chemical test for detecting peptide bonds
the biuret protein assay, a colorimetric test used to determine protein concentration by UV/VIS spectroscopy at wavelength 540 nm. Two major modifications
Biuret_test
Protein family
Rho-associated protein kinase or Rho-associated coiled-coil kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine specific
Rho-associated_protein_kinase
Type of protein
through the rearrangement of these few basic domains. Each basic domain recognizes RNA, but many of these proteins require multiple copies of one of the
RNA-binding_protein
Molecule composed of copies of a small unit
(/ˈmʌltɪmər/) is used in biochemistry for oligomers of proteins that are not covalently bound. The major capsid protein VP1 that comprises the shell of polyomaviruses
Oligomer
Basic unit of life forms
The cell is the basic structural and functional unit of all forms of life or organisms. The term comes from the Latin word cellula meaning 'small room'
Cell_(biology)
Metabolic disease involving abnormal deposited amyloid proteins
Amyloidosis is a group of diseases in which abnormal proteins, known as amyloid fibrils, build up in tissue. There are several non-specific and vague signs
Amyloidosis
Biological process
embryo, deimination of myelin basic protein plays a major role in myelin assembly. In adults, deimination myelin basic protein occurs in demyelinating diseases
Citrullination
Mammalian protein found in Homo sapiens
MyoD, also known as myoblast determination protein 1, is a protein in animals that plays a major role in regulating muscle differentiation. MyoD, which
MyoD
Laboratory technique in biochemistry
technique of precipitating a protein antigen out of solution using an antibody that specifically binds to that particular protein. This process can be used
Immunoprecipitation
Paraguayan fish soup
says "… all Guarani groups were major consumers of fish and prepared a fish meal. Fish was the basic food protein, along with game hens similar to those
Piracaldo
Group of growth factor proteins
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Professor Marshall Urist and Professor Hari
Bone_morphogenetic_protein
Cellular process of protein synthesis
of translation are initiation, elongation, and termination. The basic process of protein production is the addition of one amino acid at a time to the end
Translation_(biology)
Protein-coding gene in the species Homo sapiens
is a protein that in humans is encoded by the MYC gene which is a member of the Myc family of transcription factors. The protein contains basic helix-loop-helix
MYC
Structural motif capable of binding DNA
The helix-turn-helix (HTH) is a major structural motif in proteins that functions as a DNA-binding domain (DBD). Each monomer incorporates two α helices
Helix-turn-helix
Genes and regulatory proteins
translation into protein. Crystallised piwi domains have a conserved basic binding site for the 5' end of bound RNA; in the case of argonaute proteins binding
Piwi
Physical interactions and constructions between multiple proteins
Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical
Protein–protein_interaction
Cytoskeletal protein
the formation of the hexagonal mesh. The protein is named spectrin since it was first isolated as a major protein component of human red blood cells which
Spectrin
Protein-coding gene in the species Homo sapiens
Basic salivary proline-rich protein 3 is a protein that in humans is encoded by the PRB3 gene. The protein encoded by this gene is a proline-rich salivary
PRB3
Small structural protein motif found mostly in transcriptional proteins
A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) which stabilize the fold.
Zinc_finger
Gene that has the potential to cause cancer
three basic methods of activation: A mutation within a proto-oncogene can cause a change in the protein structure, causing an increase in protein activity
Oncogene
Protein family around which DNA winds to form nucleosomes
In biology, histones are highly-basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei and in most Archaeal phyla
Histone
Method of protein structure prediction
built based on the alignment with the chosen template. Protein threading is based on two basic observations: that the number of different folds in nature
Threading_(protein_sequence)
Protein family
and protamine-like (PL) proteins are collectively known as the sperm-specific nuclear basic proteins (SNBPs). The PL proteins are intermediate in structure
Protamine
Organic compounds containing amine and carboxylic groups
by far the most important are the 22 α-amino acids incorporated into proteins. Only these 22 appear in the genetic code of life. Amino acids can be classified
Amino_acid
Molecule that carries genetic information
nucleic acids. Alongside proteins, lipids and complex carbohydrates (polysaccharides), nucleic acids are one of the four major types of macromolecules
DNA
One of six awards by the Wolf Foundation
United Kingdom / Canada for his discovery of protein domains essential for mediating protein-protein interactions in cellular signaling pathways, and
Wolf_Prize_in_Medicine
Process that prevents the expression of a gene
precursors when joined to a protein cofactor. The general catalytic mechanism used by ribozymes is similar to the mechanism used by protein ribonucleases. These
Gene_silencing
MAJOR BASIC-PROTEIN
MAJOR BASIC-PROTEIN
Surname or Lastname
English (Lancashire)
English (Lancashire) : variant spelling of Mayer 1.Spanish and Jewish (Sephardic) : nickname for an older man or a distinguishing epithet for the elder of two bearers of the same personal name, from Spanish mayor ‘older’ (Latin maior (natus), literally ‘greater (by birth)’).Spanish and Jewish (Sephardic) : occupational or status name, from major ‘governor’, ‘chief’.Catalan : variant spelling of Major.Jewish (Ashkenazic) : variant of Meyer 2.
Female
Hebrew
 Variant spelling of Hebrew Basya, BASIA means "daughter of God."
Surname or Lastname
Jewish (Israeli)
Jewish (Israeli) : modern Hebrew name meaning ‘loom’.English : unexplained.
Male
English
 English form of French Basile, BASIL means "king." Also sometimes given as an herb name.
Boy/Male
German, Hebrew, Latin, Portuguese
Greater; Bringer of Light; Farmer; Bright One
Girl/Female
Muslim
Major
Surname or Lastname
English
English : from the Norman personal name Malg(i)er, Maug(i)er, composed of the Germanic elements madal ‘council’ + gÄr, gÄ“er ‘spear’. The surname is now also established in Ulster.Hungarian : from a shortened form of majorosgazda (see Majoros), or a derivative of German Meyer 1.Polish, Czech, and Slovak : from the military rank major (derived from Latin maior ‘greater’), a word related to English mayor and the German surname Meyer.Catalan and southern French (Occitan) : from major ‘major’ (Latin maior ‘greater’), denoting a prominent or important person or the first-born son of a family.Jewish (eastern Ashkenazic) : variant of Meyer 2.
Male
English
English surname transferred to forename use, from the Norman French personal name Mauger, MAJOR means "work-spear."
Boy/Male
Hindu, Indian, Marathi
Light; Shining
Girl/Female
Indian
Major
Boy/Male
Latin American
Greater. Also a military rank above Captain and below Colonel.
Boy/Male
Greek
Royal. Kingly. St Basil the Great was Bishop of Caesarea in the latter half of the 4th century....
Boy/Male
Latin
Great.
Boy/Male
Arthurian Legend
Accuser of Guinevere.
Surname or Lastname
English
English : patronymic from Major 1.
Boy/Male
Greek American English
Royal. Kingly. St Basil the Great was Bishop of Caesarea in the latter half of the 4th century....
Boy/Male
Arabic, Muslim
Major
Boy/Male
Hindu
King, Basil the herb
Boy/Male
Muslim
King, Basil the herb (1)
Boy/Male
American, Christian, Hindu, Indian, Latin, Punjabi, Sikh
Greater; Senior; An Office in the Army; Lord Kamdev's Another Name
MAJOR BASIC-PROTEIN
MAJOR BASIC-PROTEIN
Girl/Female
Indian, Sanskrit
Energy; Goodness; Power
Girl/Female
Latin
Accustomed.
Boy/Male
Hindi Muslim
Akbar was a 16th-century Muslim King.
Boy/Male
American, Australian, Chinese, French, Japanese, Latin, Portuguese, Spanish
Saint James; Supplanter; Saint Iago
Boy/Male
Spanish Portuguese
Prosperous guardian.
Girl/Female
Tamil
Aaditri | ஆதீதà¯à®°à¯€Â
Highest honor, Goddess Lakshmi
Female
Egyptian
, the daughter of Rameses II.
Girl/Female
Bengali, Indian, Telugu
A Garden
Girl/Female
Muslim/Islamic
Gift
Girl/Female
Muslim
Umm-Ul-Banin | عومم عو-البنین
Mother of sons
MAJOR BASIC-PROTEIN
MAJOR BASIC-PROTEIN
MAJOR BASIC-PROTEIN
MAJOR BASIC-PROTEIN
MAJOR BASIC-PROTEIN
n.
The name given to several aromatic herbs of the Mint family, but chiefly to the common or sweet basil (Ocymum basilicum), and the bush basil, or lesser basil (O. minimum), the leaves of which are used in cookery. The name is also given to several kinds of mountain mint (Pycnanthemum).
n.
The Greek major third, which comprehend two major tones (the modern major third contains one major and one minor whole tone).
a.
Having the base in excess, or the amount of the base atomically greater than that of the acid, or exceeding in proportion that of the related neutral salt.
a.
Apparently alkaline, as certain normal salts which exhibit alkaline reactions with test paper.
a.
Greater in number, quantity, or extent; as, the major part of the assembly; the major part of the revenue; the major part of the territory.
n.
The quantity contained in a basin.
a.
Said of crystalline rocks which contain a relatively low percentage of silica, as basalt.
n.
The common dooryard plantain (Plantago major).
n.
A basic silicate.
a.
Relating to a base; performing the office of a base in a salt.
n.
The constellation Charles's Wain, or Ursa Major. See Ursa major, under Ursa.
n.
The constellation Ursa Major.
n.
The major premise of a syllogism.
a.
That premise which contains the major term. It its the first proposition of a regular syllogism; as: No unholy person is qualified for happiness in heaven [the major]. Every man in his natural state is unholy [minor]. Therefore, no man in his natural state is qualified for happiness in heaven [conclusion or inference].
n.
The military rank of a major.
a.
Of or pertaining to barium; as, baric oxide.
a.
Major; in the major mode; as, C dur, that is, C major.
n.
The chief magistrate of a city or borough; the chief officer of a municipal corporation. In some American cities there is a city court of which the major is chief judge.
n.
The office of major.
a.
A mayor.