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Protein found in humans
Splicing factor 1 is a protein that in humans is encoded by the SF1 gene (previously ZNF162). This protein is involved in removing introns from pre-mRNA
Splicing_factor_1
Protein-coding gene in the species Homo sapiens
Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a
Serine/arginine-rich splicing factor 1
Serine/arginine-rich_splicing_factor_1
Proteins that aid in intron removal from messenger RNA
spliceosomes. Splicing factors regulate the binding of the snRNPs U1 and U2 to the 3' and 5' ends of the intron during splicing and can either be splicing promoters
Splicing_factor
Process in molecular biology
of RNA splicing occur in nature; the type of splicing depends on the structure of the spliced intron and the catalysts required for splicing to occur
RNA_splicing
Process by which a gene can code for multiple proteins
Alternative splicing, alternative RNA splicing, or differential splicing is an alternative splicing process during gene expression that allows a single
Alternative_splicing
Topics referred to by the same term
microbial species Serine/arginine-rich splicing factor 1, a protein also known as alternative splicing factor 1 (ASF) Advanced Synchronization Facility
ASF
Organelle in eukaryotic cells
phosphorylation of specific proteins. The splicing speckles are also known as nuclear speckles (nuclear specks), splicing factor compartments (SF compartments),
Cell_nucleus
Protein-coding gene in humans
Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the SFPQ gene. SFPQ has been shown to interact with PTBP1, NONO
SFPQ
Protein-coding gene in the species Homo sapiens
proteins, including Serine/arginine-rich splicing factor 1, which are essential precursor-mRNA splicing factors. The TNPO3-IRF5 locus is implicated in primary
Transportin-3
DNA sequence motif
an exonic splicing enhancer (ESE) is a DNA sequence motif consisting of 6 bases within an exon that directs, or enhances, accurate splicing of heterogeneous
Exonic_splicing_enhancer
Protein found in humans
Splicing factor YJU2 is a protein that in humans is encoded by the YJU2 gene (previously CCDC94). The YJU2 protein is part of the spliceosome, and is
Splicing_factor_YJU2
Protein found in humans
Insulin-like growth factor 1 (IGF1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in
Insulin-like_growth_factor_1
British television series (2004–2018)
The X Factor is a British reality television music competition – that spawned the global X Factor franchise – created by Simon Cowell. Premiering on 4
The X Factor (British TV series)
The_X_Factor_(British_TV_series)
Topics referred to by the same term
refer to: Helicase superfamily 1, a common protein. Splicing factor 1, a protein encoded by the gene SF1 Steroidogenic factor 1, a protein encoded by the gene
SF1
Protein-coding gene in the species Homo sapiens
Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene. This gene belongs to the splicing factor SR family of genes
U2 small nuclear RNA auxiliary factor 1
U2_small_nuclear_RNA_auxiliary_factor_1
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
Dierick JF, Gueydan C, Kruys V (June 2010). "The splicing factor ASF/SF2 is associated with TIA-1-related/TIA-1-containing ribonucleoproteic complexes and contributes
Stress_granule
Protein-coding gene in the species Homo sapiens
"Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing". RNA. 13 (11): 1988–99. doi:10.1261/rna
SLU7
Protein-coding gene in humans
Splicing factor 3B subunit 1 is a protein that in humans is encoded by the SF3B1 gene. This gene encodes subunit 1 of the splicing factor 3b protein complex
SF3B1
Protein-coding gene in humans
Serine/arginine-rich splicing factor 2 is a protein that in humans is encoded by the SRSF2 gene. MDS-associated splicing factor SRSF2 affects the expression
SRSF2
American reality television music competition show
The X Factor, also known as The X Factor USA, is an American reality television music competition show created by Simon Cowell and produced by FremantleMedia
The X Factor (American TV series)
The_X_Factor_(American_TV_series)
block splicing of the exon. Spliceosome Exon Intron Exon Junction Complex Long JC, Caceres JF (January 2009). "The SR protein family of splicing factors: master
SR_protein
Protein family
endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending on alternative splicing, they may be membrane-bound
VEGF_receptor
Family of proteins
pre-mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression. Pre-mRNA splicing requires
DEAD_box
Blood-clotting protein
Coagulation factor VIII (factor VIII, FVIII, also known as antihemophilic factor A (AHF)) is an essential blood clotting protein. In humans, it is encoded
Factor_VIII
Post-translational removal of peptide sequences from a protein sequence
(ATP) or guanosine triphosphate (GTP). Normally, splicing is associated only with pre-mRNA splicing. This precursor protein contains three segments—an
Protein_splicing
Protein-coding gene in the species Homo sapiens
with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role
ZRSR2
RNA produced by transcription
include the 5' cap, 3'-polyadenylation, and alternative splicing. In particular, alternative splicing directly contributes to the diversity of mRNA found
Primary_transcript
Protein-coding gene in the species Homo sapiens
Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in
SFRS7
Gene of the species Homo sapiens
protein fox-1 homolog 3 (RBFOX3) is a protein that in humans is encoded by the RBFOX3 gene. It is related to the alternative splicing factors Rbfox1 and
RNA binding protein fox-1 homolog 3
RNA_binding_protein_fox-1_homolog_3
Protein found in humans
upstream of exon 1. The BDNF-AS gene generates numerous distinct non-coding RNAs through alternative splicing. This diversity of spliced isoforms is a common
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
Protein family
recognizes the H3K9me3 methylated chromatin and recruits a splicing factor to alternatively splice the mRNA, thereby excluding the EDA exon from the mature
Heterochromatin_protein_1
Protein-coding gene in humans
Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene. In eukaryotes, the introns in the transcribed pre-mRNA first
U2AF2
Molecular machine that removes intron RNA from the primary transcript
sites of mRNA splicing or storage sites of mRNA splicing factors. It is now understood that nuclear speckles help concentrate splicing factors near genes
Spliceosome
Mammalian protein found in Homo sapiens
The transmembrane form of SCF is formed by alternative splicing that excludes exon 6 (Figure 1). Both forms of SCF bind to c-KIT and are biologically
Stem_cell_factor
Protein found in humans
represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. In particular, TDP-43 is a splicing factor binding to
TAR_DNA-binding_protein_43
Different products from the same gene
Alternative splicing generally describes a tightly regulated process in which alternative transcripts are intentionally generated by the splicing machinery
Isoform
Family of proteins involved in anatomical development
activation in the absence of FGFs. Alternate mRNA splicing gives rise to 'b' and 'c' variants of FGFRs 1, 2 and 3. Through this mechanism, seven different
Fibroblast_growth_factor
Protein-coding gene in the species Homo sapiens
Drosophila behaviour/human splicing (DBHS) family of proteins. Proteins in the DHBS family include mammalian SFPQ (splicing factor, proline- and glutamine-rich;
Non-POU domain-containing octamer-binding protein
Non-POU_domain-containing_octamer-binding_protein
Protein involved in blood vessel growth
referred to as vascular permeability factor. There are multiple isoforms of VEGF-A that result from alternative splicing of mRNA from a single, 8-exon VEGFA
Vascular endothelial growth factor
Vascular_endothelial_growth_factor
Protein-coding gene in humans
Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene. SFRS4 has been shown to interact with Pinin. GRCh38:
SFRS4
Protein-coding gene in humans
3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion
SF3A3
Protein-coding gene in the species Homo sapiens
alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They
Neuregulin_1
Protein-coding gene in the species Homo sapiens
involved in mRNA splicing and may play a role in site selection in alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family
SFRS6
alternative splicing has a role in SZ pathology. MIAT is associated with alternative splicing through its interaction with splicing factor 1(SF1) and with
MIAT_(gene)
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1
Fibroblast_growth_factor_1
Mammalian protein found in humans
Coagulation factor V (Factor V), also less commonly known as proaccelerin or labile factor, is a protein involved in coagulation, encoded, in humans, by
Factor_V
Family of proteins that bind to fibroblast growth factors
fibroblast growth factors, members of the largest family of growth factor ligands, comprising 22 members. The natural alternate splicing of four fibroblast
Fibroblast growth factor receptor
Fibroblast_growth_factor_receptor
Protein found in humans
Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome
Fibroblast growth factor receptor 1
Fibroblast_growth_factor_receptor_1
Protein-coding gene in the species Homo sapiens
Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative
SFRS9
Pharmaceutical compound
2017). "Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain". Molecular Brain. 10 (1) 23. doi:10.1186/s13041-017-0304-0
Mechano_growth_factor
instability is a genome-wide, pre-mRNA splicing-related characteristic of certain cancers. In general, pre-mRNA splicing is dysregulated in a high proportion
Transcriptome_instability
Medical condition
splicing. SON also plays a key role in alternative splicing of exons. SON is required for genome stability by ensuring the efficiency of RNA splicing
ZTTK_syndrome
Mammalian protein found in humans
Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow
Granulocyte colony-stimulating factor
Granulocyte_colony-stimulating_factor
Protein-coding gene in the species Homo sapiens
(March 1993). "Cloning and characterization of PSF, a novel pre-mRNA splicing factor". Genes & Development. 7 (3): 393–406. doi:10.1101/gad.7.3.393. PMID 8449401
PTBP1
RNA processing within a biological cell
such mRNAs do not undergo splicing and their 3' processing is done independent of most cleavage and polyadenylation factors. Core histone mRNAs have a
Post-transcriptional modification
Post-transcriptional_modification
2012 Filipino TV series or program
The X Factor Philippines is a Philippine television reality competition show broadcast by ABS-CBN. The show is based on the British reality television
The_X_Factor_Philippines
RNA element
structural motifs conserved among mammalian fibroblast growth factor 1 alternatively spliced mRNAs". Molecular and Cellular Biology. 24 (17): 7622–7635.
FGF-1 internal ribosome entry site
FGF-1_internal_ribosome_entry_site
Protein-coding gene in the species Homo sapiens
peptide. The third conserved domain of RBFOX1 is the ELAV/HuD family splicing factor. HUD is human paraneoplastic encephalomyelitis antigen D whereas ELAV
RBFOX1
Protein-coding gene in the species Homo sapiens
Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene. UCSC Genome Browser View UCSC Gene details page SFRS3
SFRS3
Protein-coding gene in humans
modified in post-transcriptional manner by alternative splicing creating different variant of mRNA. Splicing on 3´end produces transcript where 25 amino acids
Granulocyte-macrophage colony-stimulating factor receptor
Granulocyte-macrophage_colony-stimulating_factor_receptor
Protein-coding gene in the species Homo sapiens
Splicing factor, arginine/serine-rich 5 is a protein that in humans is encoded by the SFRS5 gene. GRCh38: Ensembl release 89: ENSG00000100650 – Ensembl
SFRS5
Protein with antiangiogenic properties
receptor 1 (Flt-1), sFlt-1 binds the angiogenic factors VEGF (vascular endothelial growth factor) and PlGF (placental growth factor), reducing blood
Soluble fms-like tyrosine kinase-1
Soluble_fms-like_tyrosine_kinase-1
1952 novel by John Steinbeck
Retrieved April 7, 2023. Han, John J.; Kubota, Aya (2013-01). "The Revenge Factor: Solving the Mystery of Cathy Ames in East of Eden" (PDF). Journal of Bunka
East_of_Eden_(novel)
Protein-coding gene in the species Homo sapiens
been predicted to regulate alternative splicing through its interaction with other splice factors (modulating splice site selection). In particular, it is
SREK1
Protein-coding gene in the species Homo sapiens
Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene. This gene encodes subunit 1 of the splicing factor 3a protein complex
SF3A1
Protein-coding gene in the species Homo sapiens
Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (SFRS10)
TRA2B
Protein-coding gene in the species Homo sapiens
Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene
IGFBP1
Part of a gene that is spliced away
by a tRNA splicing endonuclease. The exons are then linked together by a second protein, the tRNA splicing ligase. Note that self-splicing introns are
Intron
RNA family
base-pairing, is an important step for the future recruitment of cleavage factors during histone pre-mRNA processing. Duchenne muscular dystrophy Histone
U7_small_nuclear_RNA
Protein-coding gene in the species Homo sapiens
Splicing factor 45 is a protein that in humans is encoded by the RBM17 gene. GRCh38: Ensembl release 89: ENSG00000134453 – Ensembl, May 2017 GRCm38: Ensembl
RBM17
Protein-coding gene in the species Homo sapiens
1997). "Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing". Biochemical and Biophysical
Placental_growth_factor
both LMWK and HMWK is located on the 3rd chromosome (3q26). Alternative splicing of the KNG1 gene transcript gives rise to processed mRNA that differs by
High-molecular-weight kininogen
High-molecular-weight_kininogen
Protein-coding gene in humans
Pre-mRNA-splicing factor SPF27 is a protein that in humans is encoded by the BCAS2 gene. GRCh38: Ensembl release 89: ENSG00000116752 – Ensembl, May 2017
BCAS2
Mammalian protein found in Homo sapiens
fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Glucose-6-phosphate_isomerase
ESS regions. ESSs inhibit or silence splicing of the pre-mRNA and contribute to constitutive and alternate splicing. To elicit the silencing effect, ESSs
Exonic_splicing_silencer
Largest known protein in human muscles
alternative splicing creates some transcripts that do not encounter the premature stop codon, ameliorating its effect. mRNA splicing factors such as RBM20
Titin
Protein-coding gene in humans
Splicing factor 3B subunit 4 is a protein that in humans is encoded by the SF3B4 gene. This gene encodes one of four subunits of the splicing factor 3b
SF3B4
Mammalian protein involved in blood clotting
Coagulation factor XII, also known as Hageman factor, is a plasma protein involved in coagulation. It is the zymogen form of factor XIIa (EC 3.4.21.38)
Factor_XII
RNA family
that with the help of splicing factors Cwc25, Yju2 and Isy1 aligns a 2´ OH for an inline attack of a phosphorus atom at the 5´ splice site. Nucleophilic
U2_spliceosomal_RNA
Protein involved in coagulation
Tissue factor, also called platelet tissue factor or Coagulation factor III, is a protein present in subendothelial tissue and leukocytes which plays a
Tissue_factor
Protein found found in humans
Serine/arginine-rich splicing factor 10 is a protein that in humans is encoded by the SRSF10 gene (previously SFRS13A, FUSIP1, or FUSIP2). This gene product
SRSF10
Mammalian protein found in Homo sapiens
acts in the nucleus to regulate splicing and transcription. TIA1 helps to recruit the splicesome to regulate RNA splicing, and it inhibits transcription
TIA1
Protein-coding gene in the species Homo sapiens
Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded
HIF1A
(splicing) of an atypical class of introns, called U12-type, from pre-messenger RNAs in most eukaryotes. This process is called noncanonical splicing,
Minor_spliceosome
Protein-coding gene in the species Homo sapiens
Moreau-Gachelin F (February 1998). "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". The Journal of Biological Chemistry. 273
SPI1
Cellular process of protein synthesis
production of mRNA molecules (including splicing), initiation of these molecules with help of initiation factors (e.g., the initiation can include the circularization
Translation_(biology)
Protein-coding gene in humans
"RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing". Human Molecular Genetics. 9 (5): 685–94
RBMX
Protein found in humans
Metsis M, Timmusk T (September 1999). "Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved
RE1-silencing transcription factor
RE1-silencing_transcription_factor
Protein-coding gene in humans
large Ser/Arg (SR)-related protein, which is a splicing co-factor that contributes to an efficient splicing within cell cycle progression. It is also known
SON_(gene)
Region of non-coding DNA that regulates the transcription of neighboring genes
regulate gene transcription by binding to transcription factors. A single transcription factor may bind to many CREs, and hence control the expression
Cis-regulatory_element
Protein-coding gene in humans
Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene. This gene encodes 54-kD nuclear protein that contains
SFRS11
Protein-coding gene in the species Homo sapiens
P (Aug 1993). "Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2)". Developmental Biology. 158 (2):
Fibroblast growth factor receptor 2
Fibroblast_growth_factor_receptor_2
Type of RNA found in cells
respectively. Furthermore, RNA editing can affect the binding of splicing factors, adding an additional layer of regulation to circRNA production. Another
Circular_RNA
Protein complex assembled on mRNA
joined together during RNA splicing. The EJC has major influences on translation, surveillance, localization of the spliced mRNA, and m6A methylation.
Exon_junction_complex
InterPro Family
including von Willebrand factor. There are five named isoforms of this protein that are produced by alternative splicing. Chordin dorsalizes the developing
Chordin
Protein-coding gene in the species Homo sapiens
chromosome at Xp11.23 in humans. RBM10 is a regulator of alternative splicing. Alternative splicing is a process associated with gene expression to produce multiple
RBM10
Protein-coding gene in the species Homo sapiens
tumor progression. FGF8 signals primarily through fibroblast growth factor receptor 1 (FGFR1) to trigger downstream pathways involved in neural and limb
Fibroblast_growth_factor_8
Biological phenomenon
Dysregulation of components of the splicing machinery can also cause dysregulation of PE inclusion. Mutations in the splicing factor SF3B1 have been found to promote
Poison_exon
Class of enzymes
metabolism, muscle contraction, cell progression, neuronal activities, splicing of RNA, mitosis, cell division, apoptosis, protein synthesis, and regulation
Protein_phosphatase_1
Transcription factor gene involved in the urogenital system
activates WT1 the steroidogenic factor 1 There is some evidence for RNA editing of human WT1 mRNA. As with alternative splicing of the gene RNA editing increases
Wilms_tumor_protein
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SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
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